Sentences with phrase «hepatocytes differentiated»
Eliminating these constraints, hepatocytes differentiated from human induced pluripotent stem (hiPS) cells provide an unlimited supply of functional hepatocytes from each parental cell line, which can be derived noninvasively from a diseased or healthy person.
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HNF4α immunostaining showed over 90 % of hepatocytes differentiated with our protocol expressed HNF4α (Asplund et al. 2016).
Quantification of HNF4α immunostainings showed that over 90 % of hiPS cell - derived hepatocytes differentiated using our protocol express HNF4α [4].
Human iPS cell - derived hepatocytes differentiated with our robust differentiation protocol and cultured using a novel maintenance medium provide an inexhaustible, consistent supply of functional hepatocytes that can be used to advance the understanding of diseases related to dysfunction in liver metabolism, including NAFLD / NASH, type 2 diabetes, and metabolic syndrome.
Human iPS cell - derived hepatocytes differentiated with our robust differentiation protocol and cultured using our novel maintenance medium provide an inexhaustible, consistent supply of functional hepatocytes that can be used to advance the understanding of diseases related to dysfunction in liver metabolism, including NAFLD / NASH, type 2 diabetes, and metabolic syndrome.
Not exact matches
Our main objective was to develop a simple method that could effectively differentiate a broad number of human iPS cell lines into hepatocytes.
(A) Protocol used to differentiate the disease - specific human iPS cell library into hepatocytes.
Disease - specific human iPS cell lines generated from the individual with FH were differentiated into hepatocytes displaying typical functional characteristics (Figure 3A).
DESCRIPTION / MICROSCOPIC FINDINGS / COMMENTS: Microscopic Description: Cellularity is moderate to high consisting of clusters of well - differentiated hepatocytes which display vacuolar change consistent with lipid admixed with blood.