Sentences with phrase «hepatocytes with»

They based their approach on a system they had previously developed for studying the hepatitis C virus, in which they were able to successfully infect human hepatocytes with the virus and use it to compare antiviral regimens.

But while researchers have previously been able to infect cultures of human hepatocytes with HBV, the cells» limited lifespan has made it difficult to study the virus, says Bhatia, who is also a Howard Hughes Medical Institute investigator and a member of MIT's Koch Institute for Integrative Cancer Research and Institute for Medical Engineering and Science.

Not exact matches

Gandhi's research team is the first to develop a mouse model with depleted levels of a protein called augmenter of liver regeneration (ALR), which is essential for the survival of liver cells called hepatocytes.

The scientists started with metabolically relevant cells — hepatocytes and adipocytes — representing major functions of the liver and adipose tissues, and thus important aspects of the body's energy processing and storing system.

However, Mori confirmed in an e-mail that the problematic publication is «Downregulation of citrin, a mitochondrial AGC, is associated with apoptosis of hepatocytes,» which appeared in the 28 December 2007 issue of Biochemical and Biophysical Research Communications.

The hepatocytes are first patterned onto surfaces dotted with tiny spots of collagen, and then surrounded by supportive tissue made up of stromal cells, which act as connective tissue and support the hepatocytes in carrying out their liver functions.

This involved culturing two liver cells (hepatocytes) that can act as a functional organ unit on artificial membranes fabricated with microwell patterns.

When blood passes through the liver, it travels from arteries to veins through channels called sinusoids, lined with the liver cells called hepatocytes.

When Lin engineered the telomerase - expressing hepatocytes to die in response to a chemical signal and gave the mice with a liver - damaging chemical, he found that those animals in which the telomerase cells had been killed exhibited much more severe liver scarring than those in which the cells were functional.

Human hepatozytes filled with lipids representing macro-vesicular steatosis in hepatocytes (arrows) and inflamed cells (arrow head) caused by chronic fat diet.

Human iPS cell - derived hepatocytes differentiated with our robust differentiation protocol and cultured using our novel maintenance medium provide an inexhaustible, consistent supply of functional hepatocytes that can be used to advance the understanding of diseases related to dysfunction in liver metabolism, including NAFLD / NASH, type 2 diabetes, and metabolic syndrome.

Hepatocyte growth factor (HGF)(or scatter factor (SF) pathways - Met inhibitors could be used in combination with other treatment modalities such as; radiotherapy and / or immunotherapy in treatment of cutaneous melanoma.

Notably, both in hphep cells and enhanced hiPS - HEP cultures, only a subset of hepatocytes is strongly stained for glycogen storage — again in agreement with the metabolic zonation observed in the liver lobe (Figure 3, Panel A).

Human iPS cell - derived hepatocytes differentiated with our robust differentiation protocol and cultured using a novel maintenance medium provide an inexhaustible, consistent supply of functional hepatocytes that can be used to advance the understanding of diseases related to dysfunction in liver metabolism, including NAFLD / NASH, type 2 diabetes, and metabolic syndrome.

Notably, both in hphep cells and the enhanced hiPS - HEP cultures, only a subset of hepatocytes is strongly stained for glycogen storage (shown by Periodic acid - Schiff staining, below)-- again in agreement with the metabolic zonation observed in the liver lobe.

HNF4α immunostaining showed over 90 % of hepatocytes differentiated with our protocol expressed HNF4α (Asplund et al. 2016).

Hepatocyte nuclear factor 4α (HNF4α) is a transcription factor required for liver development and the control of expression of liver - specific genes, and it is associated with several critical metabolic pathways [3].

«Human hepatocytes are almost impossible to work with as they don't grow and are hard to maintain in culture,» explains senior author Inder Verma, Ph.D., a professor in the Laboratory of Genetics and holder of the Irwin and Joan Jacobs Chair in Exemplary Life Science.

Hepatocyte growth factor (HGF) gene therapy could be used to treat patients with severe peripheral arterial disease (PAD), suggest results...

The usual approach is to grow human cells in a dish, to infect and try to treat them there, but this is not possible with liver cells or hepatocytes.

Taking away NBTC allows human hepatocytes to take hold and populate the mouse liver with human cells.

An enzymatic defect in the tyrosine catabolism results in a toxic accumulation of byproducts within hepatocytes unless the mice are treated with a drug called NBTC.

One way to get around the altered properties of the stranded cells is to populate mouse livers with human hepatocytes in the hope of creating a natural environment, which is exactly what researchers at the Salk Institute for Biological Studies did.

We recently found that bone marrow cells can migrate into the liver upon resection and fuse with the hepatocytes.

Overall binding of both [3H] TRL preparations was significantly reduced in hepatocytes isolated from Ldlr — / — Lrp1fl / fl Alb - Cre + mice compared with hepatocytes isolated from Ndst1fl / fl Alb - Cre + mice (Figure 10).

Ag - NPs coated with galactose and mannose were considerably less toxic to neuronal - like cells and hepatocytes compared to particles functionalized by glucose, ethylene glycol or citrate.

Binding and uptake of radiolabeled ApoC - III — depleted TRLs was significantly increased in hepatocytes isolated from Ndst1fl / fl Alb - Cre + mice (i.e., in mice expressing both LDLR and LRP1) when compared with ApoC - III — bearing TRLs (Figure 10).

Galactose and mannose - coated nanoparticles were considerably less toxic to both neuronal - like cells Neuro - 2A and hepatocytes, compared to particles functionalized with glucose, ethylene glycol or citrate.

Disease - specific human iPS cell lines generated from the individual with FH were differentiated into hepatocytes displaying typical functional characteristics (Figure 3A).

DESCRIPTION / MICROSCOPIC FINDINGS / COMMENTS: Microscopic Description: Cellularity is moderate to high consisting of clusters of well - differentiated hepatocytes which display vacuolar change consistent with lipid admixed with blood.

The hepatocytes only rarely contain blue - green pigment consistent with bile or lipofuscin.

Hepatocytes are arranged in circular structures (lobules) with numerous blood channels (sinusoid spaces) separate long lines (cords) of liver cells - much like supermarket isles separate the lines of produce.