A letter from the Price - Pottenger Nutrition Foundation archives suggests that Activator X is similar to or derived from «a special kind of oxygen - containing
heterocyclic ring» called 6 - methoxybenzoaxazolinone which «acts as a sex - stimulant in voles.»
In order to avoid a second protonation at the physiological pH, a series of aminomethyl - substituted analogues, in which the second amino group was part of
a heterocyclic ring or an aromatic system, were synthesized.
Combining the Grignard reagent and Lewis Acid at a low temperature activates a carbon atom adjacent to
the heterocyclic ring and produces carbon - carbon bonds.
Some 60 related compounds were made involving
heterocyclic rings containing 12 to 60 atoms including 4 and 10 oxygen atoms.
The Term Chelate: The term chelate was first applied in 1920 by Sir Gilbert T. Morgan and H. D. K. Drew, who stated: «The adjective chelate, derived from the great claw or chele (Greek) of the lobster or other crustaceans, is suggested for the caliperlike groups which function as two associating units and fasten to the central atom so as to produce
heterocyclic rings.»
Not exact matches
Almost 90 percent of known active pharmaceutical ingredients contain one or more «
heterocyclic aromatic
rings», structures that contain atoms of at least two different elements.
This led to the identification of an analogue bearing a single azamacrocyclic
ring AMD3465 (156) and subsequently to the design of nonmacrocyclic, orally active CXCR4 antagonists preserving a p - xylyl - enediamine linker between the two
heterocyclic units of the compounds [95].
To improve the pharmaceutical properties of bicyclams, one or both
rings were replaced by smaller
heterocyclic groups.