Sentences with word «heterodimer»

Takagi was approached by Prof. Atsuko Yamashita at Okayama University who had been studying the T1r2 - T1r3 heterodimer of medaka fish for years.

PPARs form heterodimers with the retinoid X receptor (RXR) and regulate transcription of their target genes and gene networks.

For preparation reasons of the receptors, the group chose to study the medaka fish T1r2 - T1r3 heterodimer over the human version.

«T1r heterodimers can perceive most sweet and umami taste substances,» says Prof. Junichi Takagi of Osaka University.

This characteristic could explain how a single heterodimer can bind to an array of ligands.

«We need to continue to clarify the behavior of the STATs heterodimer formed by interferon alpha / beta stimulation in the presence of the C proteins.

Previously, we determined that nuclear translocation of the MAPKs p38 and JNK involves binding to heterodimers comprising importin 3 and either importin 7 or importin 9.

ACROBiosystems provides a comprehensive panel of CD3 proteins, including the exclusive Biotinylated Human CD3 epsilon as well as Biotinylated Human CD3E and CD3D heterodimer proteins.

CD3E, together with CD3 - gamma, CD3 - delta, and CD3 - zeta, and the T - cell receptor alpha / beta and gamma / delta heterodimers, forms the T - cell receptor — CD3 protein complex.

The Rel - associated protein pp40 is functionally related to I kappa B, an inhibitor of the transcription factor NF - kappa B. Purified pp40 inhibits the DNA binding activity of the NF - kappa B protein complex (p50: p65 heterodimers), p50: c - Rel heteromers, and c - Rel homodimers.

Assembly of the karyopherin heterodimer on immobilized nucleoporin yielded cooperative binding of p10 and Ran - GDP.

Comparison of the BRCC36 homodimer (top) with the BRCC36 - KIAA0157DC heterodimer (bottom) reveals similarities in MPN domain association but disorder of the helical bundle region.

The pathogenetic background of this additional alteration is completely unknown, but it is speculated that the mutant - FLT3 receptor homodimers in patients with loss of wt - FLT3 have a stronger transforming capacity compared to mut / wt heterodimers.

An alpha and beta tubulin heterodimer is the basic structural unit of microtubules.

In doing so, they have provided the first direct evidence that caspase - 9 forms both homo - and heterodimers within the apoptosome, each of which plays unique roles in the initial recruitment, activation, processing, and release of caspase - 9 from the complex.

These crystals are composed of homologous molecules, BinA and BinB, which play distinct roles in the multi-step intoxication process, transforming from harmless, robust crystals, to soluble protoxin heterodimers, to internalized mature toxin, and finally to toxic oligomeric pores.

They form heterodimers, which multimerize to form a microtubule filament.

Our bodies sense a flavour when an amino acid of the food binds to a heterodimer of two T1r members.

The research team found the heterodimer structure was approximately the same regardless of the amino acid bound, but the affinity for the amino acid was ensured together with the shell - structured water molecules around the amino acid.

Although formation of the heterodimer is necessary for perception, the findings indicated that T1r2 was responsible for detecting different amino acids and that binding to T1r3 did not have a direct role in recognizing flavours.

«To understand this perception, we looked at the atomic structure of the heterodimer.»

This heterodimer binds to a wide range of amino acids for the perception of savory flavours.

This matrix was then aligned to the human genome with the following criteria: putative off - target sites could have up to six mismatches compared to the SELEX consensus sequence, the ZFP pairs must be separated by either 5 or 6 bps, and both ZFP homo - and heterodimers were considered.

Cell cycle pro-gression is controlled by the SBF transcription factor, a heterodimer formed by Swi4 / Swi6 (from: Rodicio and Heinisch, 2010).

Using structure - based design, we engineer two variant ZFNs that efficiently cleave DNA only when paired as a heterodimer.

The heterodimer does not come apart, once formed.

(2016) The Apaf - 1 apoptosome induces formation of caspase - 9 homo - and heterodimers with distinct activities.

Two clock proteins, CLOCK (Circadian locomoter output cycles protein kaput) and BMAL1 (Brain and Muscle Arnt - like1) bind to each other to form a heterodimer complex, which then binds to a DNA sequence called E-box (CACGTG) located in the upper region of clock genes, Per (Period) and Cry (Cryptochrome), present in the genome.

The transcription factors usually function as homodimers or heterodimers to regulate the gene expression in eukaryotic cells and their activities are dependent on distinct protein - protein interaction.

P - TEFb is a heterodimer composed of cyclin - dependent kinase 9 (CDK9) and its regulatory partner Cyclin T1 or T2 (CycT1 or T2).