Pioneering work by Barrandon and Green more than 20 years ago (2) showed that when primary human keratinocytes were put in culture, their abilities to establish a clone were related to
the heterogeneity in cell size — only cells ≤ 11 μm in diameter could form a clone whereas cells ≥ 12 μm were irreversibly committed to terminal differentiation.
Not exact matches
The internalization and clustering of NPs
in living
cells (unlike the water model studied above), involves several biological processes that not only form such clusters, but also create significant
heterogeneity in their
size.