Sentences with word «heteroplasmy»

One caveat is that the authors also observed that one of the eight human embryonic stem cell lines established following spindle transfer showed a drift in mitochondrial heteroplasmy in a subset of stem cells, despite low levels of carryover detected in the embryo.

And that's where SNP's came from, that's where heteroplasmy rate change.

The presence of different types of mitochondrial DNA is known as heteroplasmy.

We detected the presence of heteroplasmy at highly stable positions of the mitochondrial genome.

Until now no one had established these frequencies, probably due to methodological reasons — we detected, with a sensitivity of 100 %, mitochondrial DNA mixtures in which minority variants were present with a frequency of only 10 % — but also because for a long time the research carried out on heteroplasmy was associated with the study of mitochondrial diseases.

A population phylogenetic view of mitochondrial heteroplasmy Wilton, P.R., A. Zaidi, K. Makova, R. Nielsen.

Moreover, the findings are not too dissimilar to those reported previously by Shoukrat Mitalipov in 2015 showing a drift in the mitochondrial heteroplasmy in embryonic stem cells established following somatic cell nuclear transfer or induced pluripotent stem cell reprogramming.

Furthermore, we found no difference in the degree of heteroplasmy between patients and healthy individuals.

The results demonstrate a high frequency of mitochondrial heteroplasmy, being heteroplasmic a 61 % of the individuals analysed.

In this study, researchers Amanda Ramos, Cristina Santos and Maria Pilar Aluja, from the Unit of Biological Anthropology of the UAB, determined the frequency and pattern of heteroplasmy in the complete mitochondrial genome of 101 unrelated healthy individuals, which are representative of the European population.

A study concerning the evolution of mitochondrial DNA, performed by researchers from the Universitat Autònoma de Barcelona (UAB), has allowed to determine the frequency and pattern of heteroplasmy in the complete mitochondrial genome using a representative sample of the European population.

With this information, they detected that several of these mutations in heteroplasmy had not been previously described at population level.

The study of heteroplasmy is proving to be useful in the study of mutation patterns, the role of selection and the mitochondrial DNA recombination in mammals.

Given the high frequency of heteroplasmy at population level, the research demonstrates that the presence of heteroplasmy is not necessarily associated with specific diseases; in fact, it is likely that most of us are heteroplasmic without affecting our health negatively,» states Amanda Ramos, lead author of the article and the PhD thesis on which the research was based on.

This situation is called «heteroplasmy».

A population phylogenetic view of mitochondrial heteroplasmy.

Do people with ME / CFS carry more copies of mitochondrial DNA with harmful mutations than healthy people (heteroplasmy)?

Regardless, the majority of blastocysts had < 2 % heteroplasmy (carryover) and none higher than 5 %.

«Using a human embryonic stem cell assay, Dieter Egli's lab shows that the majority of human embryonic stem cell lines established following spindle transfer retain similar levels of mitochondrial carryover (heteroplasmy) to that detected in the preimplantation embryo.

Four out of five lines showed low level of heteroplasmy, whereas one derived from a blastocyst with around 4 % mtDNA carryover showed an upward drift of heteroplasmy and variation among hESC colonies at the passage 12.

The authors suggest that lines with > 2 % heteroplasmy were associated with identifiable technical problems during transfer, and that this could be used to exclude them from selection for clinical implantation: however this remains to be established.

Mitochondrial heteroplasmy is responsible for Atovaquone drug resistance in Plasmodium falciparum

What's their heteroplasmy rate?