Sentences with word «heterotopic»

This bizarre shift of tissue systems, known as heterotopic ossification in most cases, can be brought on with spinal cord injury, amputation and even hip surgery.

Another coauthor from Penn Medicine, Frederick S. Kaplan, MD, the Isaac & Rose Nassau Professor of Orthopaedic Molecular Medicine and Chief of the Division of Molecular Orthopaedic Medicine, is a world expert in heterotopic ossification (HO), the abnormal buildup of bone that occurs in FOP.

Like all multiple pregnancies, heterotopic pregnancy is most common in couples who conceive with assisted reproductive procedures like in vitro fertilization (IVF).

The current study showed that HIF - 1α inhibitors, specifically the cancer drug imatinib (Gleevec), the natural product apigenin, and the small molecule PX - 478, potently inhibit dysregulated BMP signaling induced by HIF - 1α in cells, as well as heterotopic ossification following tissue injury in a mouse model of FOP.

Most importantly for individuals with FOP, the study identifies HIF - 1α as a therapeutic target — knowledge that will likely contribute to the development of more effective treatments for FOP and related common disorders of heterotopic ossification.

«Rapamycin treatment prevents crippling abnormal bone formation after severe limb injuries: Significant benefits seen after treatment with FDA - approved drug in rodent model of blast - related limb injury hold promise for first effective treatment to prevent trauma - induced heterotopic ossification (HO) formation.»

This pattern had low sensitivity and specificity: relatively few patients with such symptoms develop BD, while many young people without heterotopic symptoms do develop BD.

There are more common instances of bone formation called heterotopic ossification.

With mice, we can do a lot of studies to understand what will initiate heterotopic ossification.

This adjustment profoundly reduced heterotopic ossification and the resulting disability in the FOP mouse.

Surprisingly, HIF - 1α dramatically amplifies the already mutant bone morphogenetic protein (BMP) signaling in the oxygen - starved cells and stimulates heterotopic ossification, the abnormal metamorphosis of muscle to bone that occurs in FOP.

Neurological heterotopic ossification following spinal cord injury is triggered by macrophage - mediated inflammation in muscle.

Whereas for Foucault the mirror was an ideal site of heterotopic duality, Bourque - LaFrance's hybrid paintings are positioned somewhere between textiles, smartphone screens and commercial or historical vitrines, potentially hopeful and meditative fields where the viewer projects one's fears and desires, but that never fully reveal themselves.

Sure, it is a box rather than a ring, but the concept is strikingly similar: an inward - looking, hermetic, heterotopic corporate world.

In narratives both real and imagined, Wood depicts the jumble of everyday life in heterotopic yet cohesive wholes, in more than 50 limited edition prints produced between 2004 and 2018.

In the long run, better methods for stopping internal bleeding, more advanced regenerative, transplant and prosthetics technologies, and new drugs to prevent complications such as heterotopic ossification, are hoped to further improve care for DCBI patients.

This print survey demonstrates his intuitive synthesis of the jumble of everyday life into a series of heterotopic yet cohesive wholes.

Individuals who experience severe injuries to their extremities, whether due to military combat or other trauma, often develop abnormal extra-skeletal bone in the damaged or healing tissue, a process known as heterotopic ossification (HO).

As many as two in 1,000 assisted pregnancies result in a heterotopic pregnancy.

If you have experienced loss of a fetus due to a heterotopic pregnancy, it is perfectly normal if you find yourself grieving that baby even if the other is fine.

The discussion also covers the management of common long - term complications such as heterotopic ossification, in which solid masses of bone begin growing inappropriately within soft tissues near blast injury sites, and the formation of blood clots in the extremities and lungs, which occurs at a high rate in DCBI survivors.

In many cases, heterotopic ossification has formed at amputation sites making it difficult to fit prostheses.

«Our study provides profound insight into the role of cellular hypoxia in FOP flare - ups and shows that cellular oxygen sensing through HIF - 1α is a critical regulator of the BMP pathway and heterotopic ossification in FOP,» Kaplan said.

This heterotopic bone formation is the most clinically relevant feature of FOP.

Through the combination of single - author streams and multi-author channels we aim to enable participatory engagement with various points of focus within a heterotopic field.

Katya Tylevich introduces us to the heterotopic spaces behind Walead Beshty's photographs, while Robert Shore unravels the processes that lead up to the multidisciplinary work of protean artist duo Davy and Kristin McGuire.

Putting forth a heterotopic environment in which resonances emerge between various art methodologies (music, painting, performance, sculpture, dance / movement, word, optics) novel forms of ritualized space emerge.

Polke's works were everything painting wasn't supposed to be: vulgar, mocking, parodic, decorative, heterotopic, discontinuous, self - reflexive and self - critical.