Sentences with phrase «heterozygosity means»

Absence or reduced heterozygosity means that a patient's genome contains long stretches of homozygosity, which can be problematic if that region harbors a variant in an autosomal recessive disease gene.

Not exact matches

Segment coordinates and corresponding heterozygosity estimates [mean log (Watterson estimator)-RSB- were extracted.

SR = Santa Rosa Island, SC = Santa Cruz Island, LA = Los Angeles County, SB = Santa Barbara County, CC = Central California (Alameda and Contra Costa counties), LT = Lake Tahoe (El Dorado, Placer, and Alpine counties, California and Lyon and Douglas counties, Nevada), NC = Northern California (Humboldt and Trinity counties), and OR = Oregon (Clatsop, Tillamook, Lincoln, and Clackamas counties), n is number of individuals sampled, A is mean allelic richness, and HO and HE are mean observed and expected (Nei 1978) heterozygosity, respectively (range across 8 loci in parentheses).