Sentences with phrase «heterozygous parents»

Homozygous loss - of - function offspring of two heterozygous parents occurred less frequently than expected (deficit of 136 per 10,000 transmissions for variants with MAF < 2 %, 95 % confidence interval (CI) = 10 — 261).

In June, he and his colleague Thaddeus Stappenbeck argued in Nature that all mouse studies should use littermate controls: When studying the activity of a particular gene, breed mice with and without that gene by starting with heterozygous parents.

Not exact matches

Thus, while XL280α shares markers with both parents, it only has one copy of each chromosome (it is haploid) and is not heterozygous anywhere in its genome.

Parents transmit their alleles to offspring according to autosomal Mendelian genetic rules; thus, if a parent is homozygous, then that parent transmits one mutation; if heterozygous, then the mutant allele is transmitted with 50 % probability.

This involved 53 variants in total, about half of which were homozygous in the patient and heterozygous in both parents.

If two dogs are both heterozygous for furnishings, there is a 25 % chance that each offspring could get the non-furnishings allele from each parent and not display that trait.

Follow - up genotyping revealed that all 5 cases were homozygous for the mutant allele, both parents were heterozygous, and ten sibs and first degree relatives were heterozygous or homozygous for the reference allele.