Sentences with word «hexokinase»

In dogs with normal sugar metabolism, glucose in the lens is metabolized by an enzyme called hexokinase into small molecules that diffuse out of the lens.

By blocking the enzyme hexokinase, it prevents glucose phosphorylation.

While all humans have this fifth hexokinase, it appears during pregnancy, women with less of this gene are not able to metabolize glucose as well, the study showed.

«Knowing that there is this new hexokinase at play could also give us more information on how to inhibit or activate it, and anything we can to do disrupt the cycle would be an important advance to stem the epidemic of diabetes we see today.»

PPAM showed synergism with STAT3 inhibitor S3I - 201, glucose hexokinase inhibitor 2 - deoxy - D - glucose (2 - DG) and dasatinib, thus confirming STAT3 pathway and glycolysis / autophagy as targets.

If hexokinase activity is reduced relative to glucose transport activity in diabetes, one would predict a substantial increase in intracellular glucose, whereas if glucose transport activity is primary reduced in diabetic cultures, we would expect a decreased intracellular glucose concentration.

If the urinalysis and the laboratory work are unable to provide complete answers, further testing could involve hexokinase or glucokinase dehydrogenase tests, which are enzymatic glucose assessments.

The discovery of these four catalysts for energy production, called hexokinases, generated more research into how the body metabolizes carbohydrates, and how interfering with those enzymes through medications could help manage metabolic disorders such as diabetes.

According to research by scientists at Duke and Northwestern universities, the hexokinase team actually has a fifth player.

«Hexokinases are critical to basically all of our energy production.

Many of the genes known to be directly transactivated by the overexpression of the transcription co-factor HIF - 1α were identified, and included inducible nitric oxide synthetase 2, insulin - like growth factor 1, insulin - like growth factor binding protein 2, and hexokinase 2.

Scientific studies, performed in 2005 suggest that cats, which in Nature are strict carnivores, do not produce sufficient Glucokinase and Hexokinase, liver enzyme that are necessary for the metabolism (use) of glucose.

When the glucose levels are high, hexokinase can not keep up and the excess glucose is metabolized by aldose reductase into sorbitol.