Sentences with phrase «high myc»

Ayer said that if this result is validated in clinical trials, then looking for the high Myc, low TXNIP signature will identify women at high risk for recurrence who could then be treated more aggressively and watched more closely.

«We found that PIM1 is indeed highly upregulated in these more aggressive breast cancers that have high MYC expression,» Goga said, «and that patients with high PIM1 tend to do more poorly.»

Not exact matches

The contest ends after a week; at that time, Clavería predicts, surviving cells produce uniform (and higher) levels of Myc.

In the cell culture systems, c - MYC protein will always be at a high level.

To address this question, the research teams from Berlin and Würzburg took a closer look at human colon carcinoma cell lines that innately show high levels of c - MYC.

The c - MYC pathway appeared to some researchers to be an unlikely therapeutic target for beta cell regeneration because past studies had found it to cause beta cell death when activated in high doses.

«We discovered that lymphoma cells with high levels of MYC can be killed by disabling a protein called MCL - 1.

High REV - ERBa or low BMAL1 predicts poor clinical outcome in N - MYC - driven human neuroblastomas.

This strategy grew out of previous work in the Goga's laboratory showing that MYC expression is disproportionately higher in triple - negative tumors than in tumors expressing hormone receptors and / or HER2.

They discovered that lymphomas that have high levels of MYC can not survive long - term without a protein called MCL - 1 which makes cells long - lived.

«Our study reveals important differences and specificities in the mechanism of action of high - and low - dose aspirin in metastatic and nonmetastatic cancer cells with different tumor origins and suggests that the ability of aspirin to prevent platelet - induced c - MYC [an oncoprotein] expression might be selective for a nonmetastatic phenotype.»

Corroborating this finding, high levels of Myc combined with low levels of TXNIP correlate with poor patient outcome when examined in large clinical datasets.

The data suggests that high levels of Myc and low levels of TXNIP promote triple negative breast cancer cell growth and survival.

The authors undertook a higher - resolution survey of these associations within tumor subtypes, finding known driver events, such as amplifications of MYC, CCND1, ERBB2, and CCNE1 and deletions of PTEN and MDM2, as well as putative but suggestive events involving MDM1, MDM4, CDK3, CDK4, PI4KB, NCOR1, and others.

In comparison, mouse NSCs were reported to express twofold higher levels of Sox2, an eightfold lower level of Klf4, and a tenfold higher level of c - Myc expression relative to mouse ESC expression levels [14].

Our results showed that hNSCs express 1.4 fold higher levels of SOX2, fourfold lower levels of c - MYC, and threefold lower levels of KLF4 relative to hESC expression levels.

Cells that express high levels of the transcription factor myc up - regulate glutaminase expression more than 10-fold [105].

Interestingly, despite the fact that the NSCs were immortalized with ectoptic expression of myc, the transcriptional activity of myc is higher in iPSCs compared to NSCs.

Of note, mouse neural stem cells (NSCs) were reprogrammed using only one (Oct4) or two factors (Oct4 and Klf4), due to the endogenously high expression of pluripotent genes, such as Sox2 and c - Myc, as well as several intermediate reprogramming markers [14], [17], [18].