Sentences with phrase «high affinity»

Many of these toxins have a particularly high affinity for becoming stored in body fat.

A particular challenge, one that could have important therapeutic applications, is to design an antibody that binds with high affinity to a target protein.

According to many studies, mercury has a particularly high affinity for the molecular structure of collagen.

Linkage of the two sequences and expression of a recombinant scFv of mAb 5.91 with confirmation of high affinity binding to canine IgE was completed in November, 2011.

Our data that P - TEFb and SEC are associated with the genes encoding decisive EMT regulators but not non-responsive genes suggest that the direct target EMT genes may contain sequences that display high affinity binding to the SEC - P - TEFb complex.

The compounds reported in this study, particularly the phenylguanides, have advantages largely because they showed higher affinities for CXCR4 and were compounds with a defined chemical composition, rather than heterogeneous mixtures such as NB325.

«Tfh cells control the whole process of generating high affinity antibodies, and ICOS is a receptor molecule strongly required for Tfh cells to work.

«Our work shows that Pancreatic Polypeptide has a very high affinity for Y6 in mice.

This suggests the immunogens imposed constraints resulting in a common structural mode of high affinity encoded by different sequences.

The Garon Strongarm has lower attack and fire element power than the Rathsblade but has a much higher affinity rate.

«The material has more than 10 times higher affinity for PFOA than activated carbon, a conventional treatment method with several known deficiencies.»

Shea notes that although he and his colleagues have yet to finalize their measurements on how well their nanoparticles bind to various PLA2 molecules, their test - tube results suggest that they could have a similar high affinity for PLA2s as their previous nanoparticles had for melittin, the bee venom protein that stopped the toxin in animal studies.

Higher affinities let narrow neutralizing HIV antibodies outcompete broadly neutralizing HIV antibodies early in infection.

Without Foxo1, germinal center structure is disorganized and mice could not produce high affinity antibodies against foreign antigens.

On the other hand, high affinity cells, which receive strong stimulation from antigen and antigen specific CD4 T cells, have difficulty maintaining Bach2 expression at high levels and tend to be induced to form plasmablasts (plasma cells).

Now, Shimamoto has developed inhibitors which have several thousand fold higher affinity.

In bacteria, the ligand - PBP complex develops high affinity for transmembrane proteins such as Trg, and the chimeric Trg - HK protein allows activation of gene expression with one additional protein, a bacterial response regulator [5].

Importantly, ACE has relatively higher affinities for rodent nAChRs than other neonicotinoids [16], and little published information is available regarding its effects on mammalian nAChRs.

As an immune response develops, antibodies mutate toward higher affinity.

However, higher affinity anti-cancer antibodies would also increase adverse side effects; they more effectively attack both the tumor and other tissues that express the same antigen.

We have now demonstrated that NG2 is capable of binding PDGF - AA (but not PDGF - BB) with fairly high affinity, and thus may participate in sequestering the growth factor or in presenting it to the signaling receptor (Goretzki et al, 1999).

Iron Transport: Lactoferrin has an extremely high affinity for iron.

In the early 1970s, Swedish researchers showed vitamin D3 to have a substantially higher affinity for human DBP than vitamin D2.49 Their sample size was not reported and probably very small, and they unfortunately could not test the calcidiol forms of these vitamins because 25 - hydroxyvitamin D3 was at that time not yet commercially available.

But mercury has a far higher affinity for the thiols than do beneficial metals like zinc.

For Mid game the Ceanatur bow (I think thats how you spell it) is good for larger monsters because of pierce, towards the end of the game the akantor bow is probably the best because of raw damage, high dragon element and high affinity chance.

«Indians, in general, have high affinity towards crypto investments, just look at the growth in awareness and money infused in cryptocurrency market in India in just last six months, and it's growing day - by - day,» Gupta concludes.

2) To generate a plant - derived recombinant, nonanaphylactic, scFv with high affinity for IgE that can be scaled up for production at kilogram amounts.

Also promising was the finding, in tests on several of the responders, of vaccine - induced T - cells that showed high affinity for unique structures («neoepitopes») on their tumors.

CTLA4 has very high affinity for CD28.

Thus, this study has implications for analysis of human vaccine studies, as in addition to searching for defined lineages it is worthwhile to perform functional analysis of monoclonal antibodies that may have found new structural solutions to high affinity binding which can not be discerned from DNA sequence alone.

Mechanistically, cells in this memory - prone fraction had higher expression of the transcriptional repressor Bach2 than that of their counterparts with BCRs of higher affinity.

These two are metabolized quite differently, human amylases having much higher affinity to the branched amylopectin.

Physiologists have long known that many high - altitude animals have evolved hemoglobins with high affinities for oxygen, which can enhance oxygen uptake in thin air.

Both moves appear aimed at Snapchat, the app with which Kik has the highest affinity, says Waldron, meaning users of one are likely to have downloaded the other.

Use these customer insights to build out specific user experiences, including messaging, creative, and website experience to ensure you target audiences that have a higher affinity for your products and services.

Given that the newly discovered protein FGB1 has such a high affinity and specificity to beta -1,6-glucans from fungi cell walls, it is possibly suitable for the diagnosis of human infections.

«Elevated» responses — those that indicated a higher affinity for chocolate milkshakes — predicted fat gain three years later.

This method is directly applicable to sodium, calcium, and other ion channels where inhibitor or modulatory proteins bind with high affinity.

The animal's blood can trap substantial amounts of oxygen because its blood pigment, haemocyanin, has a high affinity for oxygen.

A generation of young adults raised on electronic devices has a high affinity for the gadgets and engages in less face - to - face contact than was once the norm, he says.

«We found that the host class of cucurbiturils has a higher affinity to steroids used for medical purposes than cyclodextrines,» Frank Biedermann, scientist of the KIT Institute of Nanotechnology, explains.

The resulting antibody has a high affinity for the polymerized form of fibrin and a low affinity for the precursor material.

Prof. You - Me Kim and her student Dajung Jung at Pohang University of Science and Technology (POSTECH), in collaboration with Prof. Wonhwa Cho's group at the University of Illinois at Chicago, have identified that the majority of human Src homology 2 (SH2) domains not only bind to proteins, but also interact with membrane lipids with high affinity and specificity.

«We need to make better antibodies that have high affinity for pathology and not the normal protein,» says Lee.

Innova Biosciences FlexLISA kits are designed for the development and optimization of sandwich ELISA assays to detect the presence of any antigen with a high affinity for any antibody pair in complex samples (serum, plasma, urine, and more).

However, when it does bind, MinE is rapidly converted into the open form, which has a high affinity for MinD - ATP.