Sentences with phrase «high affinity binding»

A high affinity binding site for HP1 can be produced by silencing Lys9 of histone H3 by methylation with mammalian histone lysing methyltransferase, a suppressor of variegation 39H1 (SUV39H1).

Remarkably, both lineages have incurred a three - residue deletion in CDR2 during maturation suggesting the immunogens imposed constraints which resulted in a similar structural solution to high affinity binding that was achieved by different underlying sequences.

Thus, this study has implications for analysis of human vaccine studies, as in addition to searching for defined lineages it is worthwhile to perform functional analysis of monoclonal antibodies that may have found new structural solutions to high affinity binding which can not be discerned from DNA sequence alone.

Not exact matches

This approach was applied to the Shaker potassium channel and to a high - affinity peptide inhibitor (scorpion toxin) that binds to its pore entryway.

Shea notes that although he and his colleagues have yet to finalize their measurements on how well their nanoparticles bind to various PLA2 molecules, their test - tube results suggest that they could have a similar high affinity for PLA2s as their previous nanoparticles had for melittin, the bee venom protein that stopped the toxin in animal studies.

In Class II engagement, Sox9 binds to multiple active enhancer elements through sub-optimal, low - affinity Sox dimeric motifs (DNA sequences), resulting in a high level of transcription of cartilage - related genes.

Prof. You - Me Kim and her student Dajung Jung at Pohang University of Science and Technology (POSTECH), in collaboration with Prof. Wonhwa Cho's group at the University of Illinois at Chicago, have identified that the majority of human Src homology 2 (SH2) domains not only bind to proteins, but also interact with membrane lipids with high affinity and specificity.

By fusing that sequence to three growth factors they were able to increase their binding affinity by 2 - to 100-fold, which could reduce the need for higher doses in the future.

Results showed that 29 patients» scans revealed strong - binding metastases with a high affinity for the imaging agent.

Antibodies with a high target - binding affinity are known to be effective against cancer.

The most active derivatives of phenylguanides were characterized by the presence of aromatic groups on the main chain, have shown high binding affinity than the melamine derivative (THAM trisguanide), demonstrating the importance of the position of aromatic groups themselves.

Diannexin, an annexin A5 homodimer, binds phosphatidylserine with high affinity and is a potent inhibitor of platelet - mediated events during thrombus formation.

Specific interaction of benzimidazole anthelmintics with tubulin: high - affinity binding and benzimidazole resistance in Haemonchus contortus.

Source: «High - affinity binding and direct electron transfer to solid metals by the Shewanella oneidensis MR - 1 outer membrane c - type cytochrome OmcA.»

In other words, Ras proteins naturally lack areas that are accessible, high - affinity binding targets for potential therapeutic agents.

Auxin, says Zheng, acts like «molecular glue» by filling in the gaps in this weak binding and allowing the proteins to bind with high affinity.

CHiP - Seq peaks lacking cognate binding motifs had 21 % lower median scores, and most (82 % of them) had high - affinity recognition sequences for other factors.

In this study, the researchers demonstrated in a series of in vitro experiments that squalamine, a positively charged molecule with a high affinity for negatively charged membranes, could literally «kick off» α - synuclein from negatively charged membranes, where the protein binds, preventing the formation of the toxic clumps.

Peptides can target the ephrin - binding pocket of Eph receptors with high affinity and specificity, affecting receptor function.

Iterative cycles of hypermutation and selection continue until antibodies of high antigen binding specificity emerge (affinity maturation).

A particular challenge, one that could have important therapeutic applications, is to design an antibody that binds with high affinity to a target protein.

The observation that the cholera toxin B (CtxB) subunit, a multivalent counter-receptor that binds with high affinity and specificity to GM1 (8), produced the same effects as the Treg product Gal - 1 served to emphasize the pivotal role of GM1 cross-linking in Teff suppression (7).

It is possible that the vitamin D concentrations of the milk would have been higher if the mothers had been consuming only vitamin D3, the animal form of vitamin D. Vitamin D is carried into breast milk attached to the vitamin D - binding protein; 21 since one study found vitamin D2 to have a lower affinity than vitamin D3 for the vitamin D - binding protein, it may be that vitamin D3 is much more effective than vitamin D2 at raising the levels of vitamin D in milk.

Certain toxic metals have a high affinity for sulfur and will bind tightly to the essential cysteine, inhibiting the enzyme from functioning.

It's also binding up a as an — high affinity to Selenium as well.

Mercury has a high affinity for many thiol enzyme bonds in your body and it causes inflammation and cell death when it binds to them.

In addition, HIV - 1 transactivating protein (Tat) has a unique cysteine - rich region with zinc binding properties (Huang and Wang 1996) and has a high binding affinity for zinc (Frankel et al. 1988).

The affinity of cobalamin for haptocorrin is higher at acid pH than for IF, so most is bound to haptocorrin in the stomach.

And even if what eeveryone cared about in practice was some simple high - level summary like the function of a protein (e.g., something like the O2 affinity of hemoglobin), nobody would present a new model with hundreds of parameters and focus only on its fit to a few - parameter curve of bound O2 vs. partial pressure of O2.

«Mammalian histone lysine methyltransferase, suppressor of variegation 39H1 (SUV39H1), initiates silencing with selective methylation on Lys9 of histone H3, thus creating a high - affinity binding site for HP1.