Sentences with phrase «high affinity for»

Koei Tecmo also noted that as well as global expansion it will also be good for the company to aggressively market their titles in Asia where there is a high affinity for Japanese IP's.

The unit is comprised of soldiers who have a high affinity for ragnite, and even Jutland's own Princess Ophelia has joined the ranks.

Objective 2: To generate a plant - derived recombinant, nonanaphylactic, single - chain antibody fragment with high affinity for IgE that can be scaled up for production at kilogram amounts.

2) To generate a plant - derived recombinant, nonanaphylactic, scFv with high affinity for IgE that can be scaled up for production at kilogram amounts.

Objective 1: To create a recombinant, nonanaphylactic, single - chain antibody fragment (scFv) with high affinity for canine IgE from the variable region gene sequences of mAb 5.91 clones.

The unit is comprised of soldiers who have a high affinity for ragnite, and even Jutlands own Princess Ophelia has joined the ranks.

Mercury has a high affinity for many thiol enzyme bonds in your body and it causes inflammation and cell death when it binds to them.

Many of these toxins have a particularly high affinity for becoming stored in body fat.

Certain toxic metals have a high affinity for sulfur and will bind tightly to the essential cysteine, inhibiting the enzyme from functioning.

Witch hazel antioxidants even have a particularly high affinity for human skin cells.

They claimed that witch hazel had a high affinity for human cells and cell membranes and hence was highly equipped to defend them against reactive oxygen species (free radicals).

In terms of dental health and adrenal fatigue, it has been shown in many research papers that mercury has a high affinity for all endocrine glands (adrenal and thyroid inclusive).

Iron Transport: Lactoferrin has an extremely high affinity for iron.

CTLA4 has very high affinity for CD28.

In this study, the researchers demonstrated in a series of in vitro experiments that squalamine, a positively charged molecule with a high affinity for negatively charged membranes, could literally «kick off» α - synuclein from negatively charged membranes, where the protein binds, preventing the formation of the toxic clumps.

In bacteria, the ligand - PBP complex develops high affinity for transmembrane proteins such as Trg, and the chimeric Trg - HK protein allows activation of gene expression with one additional protein, a bacterial response regulator [5].

Results showed that 29 patients» scans revealed strong - binding metastases with a high affinity for the imaging agent.

«We need to make better antibodies that have high affinity for pathology and not the normal protein,» says Lee.

The resulting antibody has a high affinity for the polymerized form of fibrin and a low affinity for the precursor material.

A generation of young adults raised on electronic devices has a high affinity for the gadgets and engages in less face - to - face contact than was once the norm, he says.

Shea notes that although he and his colleagues have yet to finalize their measurements on how well their nanoparticles bind to various PLA2 molecules, their test - tube results suggest that they could have a similar high affinity for PLA2s as their previous nanoparticles had for melittin, the bee venom protein that stopped the toxin in animal studies.

«Elevated» responses — those that indicated a higher affinity for chocolate milkshakes — predicted fat gain three years later.

Interestingly, an imaging study comparing DA increases using BPND and 4 - propyl -9-hydroxynaphthoxazine -LRB-[11C] PHNO)(radiotracer with > 20-fold higher affinity for D3 over D2 receptors, and presumably more sensitive to competition with endogenous DA)(63, 64) in response to a stressor in individuals at high risk for schizophrenia showed that those who abused marijuana had a blunted response, consistent with decreased DA signaling (22).

«We are trying to determine what kind of minerals in soil have a higher affinity for uranium; that is, what it will stick to,» said Dr. Nikolla Qafoku, a PNNL geochemist, who with Dr. Ravi Kukkadapu, an EMSL chemist, is lead author of the paper, which appears in Environmental Science & Technology.

Importantly, ACE has relatively higher affinities for rodent nAChRs than other neonicotinoids [16], and little published information is available regarding its effects on mammalian nAChRs.

When one gas species has a higher affinity for the pore walls than other gas species, metal - organic frameworks can be used to separate gaseous mixtures by selectively adsorbing.

Interestingly, several analogs of MolPort -016-359-762 also showed higher affinities for the active site pocket of RIPK2, suggesting a high preference of this scaffold for the active site pocket.

In the early 1970s, Swedish researchers showed vitamin D3 to have a substantially higher affinity for human DBP than vitamin D2.49 Their sample size was not reported and probably very small, and they unfortunately could not test the calcidiol forms of these vitamins because 25 - hydroxyvitamin D3 was at that time not yet commercially available.

But mercury has a far higher affinity for the thiols than do beneficial metals like zinc.

The body has a higher affinity for glucose; therefore the body will let glucose in faster than Vitamin C.

Not exact matches

To understand why graduation rates in computer science are so low for women, we only need to answer one question: Why do 74 % of high school girls report affinity for STEM subjects in school and yet, according to a report by the Girl Scout Research Institute, only about 20 % pursue STEM - related undergraduate degrees?

Higher volatility may help some active managers, but investors will need to see long periods of outperformance before reconsidering their affinity for passive investments.

That went on for some time with only minor hiccups such as happens whenever humans gather until at some point, unbeknownst to me, we seemed to have slipped into this point where we were expected to have an affinity for the denomination and thus automatically hold its leadership in high regard and limit our criticism of such.

Even though he's handsome, his affinity for comic books, video games and Death Cab For Cutie have landed him an outside seat to the goings - on of his rich counterparts in his high schofor comic books, video games and Death Cab For Cutie have landed him an outside seat to the goings - on of his rich counterparts in his high schoFor Cutie have landed him an outside seat to the goings - on of his rich counterparts in his high school.

I find, for example, the five following characteristics in these liturgies: (1) an affinity with the liturgies of the ancient church; (2) an order that follows the pattern of revelation and Christian experience; (3) a significant emphasis on reading and hearing the Word of God; (4) a high degree of congregational involvement; and (s) a view of the Lord's Supper which affirms its mystery and value for spiritual formation.

Several other large high schools in the area, including Maine South in Park Ridge and Barrington, use a homeroom program to help students develop an affinity for the school and classmates.

He recalled how his father used a «pine rolltop desk from a vocational high school in Buffalo» at the executive mansion in Albany, how Mario felt a «natural affinity» for Buffalo and its people, a devotion forged by a shared perspective that began in Mario's Great Depression childhood.

Given that the newly discovered protein FGB1 has such a high affinity and specificity to beta -1,6-glucans from fungi cell walls, it is possibly suitable for the diagnosis of human infections.

«We found that the host class of cucurbiturils has a higher affinity to steroids used for medical purposes than cyclodextrines,» Frank Biedermann, scientist of the KIT Institute of Nanotechnology, explains.

«Tfh cells control the whole process of generating high affinity antibodies, and ICOS is a receptor molecule strongly required for Tfh cells to work.

By fusing that sequence to three growth factors they were able to increase their binding affinity by 2 - to 100-fold, which could reduce the need for higher doses in the future.

In 1984 Brown's affinity for the working class took hold again when he arrived in the town of Woburn, Massachusetts, 12 miles north of Boston, along with a scientific team looking into an alarmingly high rate of leukemia in both children and adults: 19 cases in one decade, with only two survivors.

There are a number of reasons why the trials may have failed, Hardy says, including the possibility that the antibody did not have high enough affinity for the particular forms of amyloid that do the most damage in the brain, or that the patients in the trials had already experienced too much brain degeneration to benefit.

Thus, this study has implications for analysis of human vaccine studies, as in addition to searching for defined lineages it is worthwhile to perform functional analysis of monoclonal antibodies that may have found new structural solutions to high affinity binding which can not be discerned from DNA sequence alone.

There are also differences in the affinity of different transporters for specific drugs: for example, the high - affinity transporters OCT1 and / or OCTN2 are functional at the basolateral membrane of rat Sertoli cells, whereas the low - affinity transporters OCT3 and / or OCTN1 are functional at the apical membrane (43).

Genetically engineered mice now act as robust engines for the generation of diverse repertoires of affinity - matured, fully - human variable regions with intrinsic drug - like properties necessary for successful development including high potency, specificity, manufacturability, solubility and low risk of immunogenicity.

SAR studies indicated that the central aromatic ring is crucial for high CXCR4 affinity, and that a one - carbon separation between the central aromatic phenyl ring and the nitrogen of the acyclic linker is strictly required for potency.

In other words, Ras proteins naturally lack areas that are accessible, high - affinity binding targets for potential therapeutic agents.

The next step may be to follow up on these promising results and customize the small molecules for a higher affinity fit.

CHiP - Seq peaks lacking cognate binding motifs had 21 % lower median scores, and most (82 % of them) had high - affinity recognition sequences for other factors.