Sentences with phrase «high copy numbers»

Both the hunter - gatherers as well as the early farmers displayed high copy numbers of amylase genes in their genomes, suggesting that both populations had already adapted to a starch - rich diet.

Its characteristically low mutational burden, high copy number and structural variants, and unique driver mutation prevalence are important in helping us understand the natural history of the disease and its response to various therapies.

Over the next few years genes from different bacterial (and eventually mammalian) species were cloned into plasmids and new cloning vectors such as pBR322, pACYC, and pUC were developed to provide higher copy number vectors that could be used in these cloning experiments.

Oral and vaginal swab samples, in contrast, showed higher copy numbers.

Not exact matches

NEW YORK (AP)-- James Comey's «A Higher Loyalty» had a very big opening week.Flatiron Books announced Tuesday that sales topped 600,000 copies, a number that includes print, audio and e-books.

During the school year 1963 — 1964 some 250,000 copies of the three texts were sold, a number sufficient to reach 12 percent of the high school biology students in the U.S.. All three have been offered to and accepted by state adoption boards in Georgia and Florida.

Venken first sought a vector that could handle large amounts of DNA efficiently, settling on a bacterial artificial chromosome, which was designed a couple years ago and is known to maintain only a few copies of the DNA (though it can produce a high number of copies if it is induced).

Scherer and his colleagues, who included population geneticist Matthew Hurles of the Wellcome Trust Sanger Institute in Cambridge, England, followed up with a higher - resolution CNV study in 2006, which analyzed DNA from 270 individuals and identified an average of 47 copy number variations per person.

«Sometimes the criteria for HER2 positivity is a high level of HER2 protein, sometimes it's over-expression of the HER2 gene, and sometimes it's high HER2 copy number.

But the average individual had lost both copies of roughly 20 genes, which means the gene is essentially missing — a surprisingly high number, MacArthur says.

This is consistent with recent findings that AMY2B copy number is highest in modern dog populations originating from geographic regions with prehistoric agrarian societies, and lowest from regions where humans did not rely on agriculture for subsistence34 and supports the claim that the expansion occurred after initial domestication (possibly after the migration of dingoes to Australia 3,500 — 5,000 years ago) 34.

The copy number high subtype was composed of mostly serous tumors, but included some endometrioid samples.

ETP - ALL tumors exhibit an unusually high burden of DNA copy number alterations, but no unifying genetic have been identified.

The patterns of somatic copy number changes, as assessed by high - density SNP array, suggest widespread segmental CNA instability:

CCG uses high - throughput techniques to identify and study mutations, large rearrangements of the genome, increases and decreases in DNA copy number, chemical modifications to DNA, and changes in the expression of RNA and proteins.

The development of high - throughput screening methods such as array - based comparative genome hybridization (array CGH) allows screening of the human genome for copy - number changes.

Using DECoN (which stands for Detection of Exon Copy Number variants), the researchers took advantage of the high density of sequencing data available in new gene panels to accurately detect deletions or duplications of exons.

They showed that removal of the tails resulted in the retention of 1.4 to 7.8 times higher number of copies in four out of five colon - specific genes expressed at low levels after subtraction.

Another distinctive genetic feature of mucosal melanoma is its high rate of copy number and structural variants, demonstrated both by array - based comparative genomic hybridization and whole - genome sequencing.

We aim to push its limits on all fronts to establish a technique which combines nanometre 3D resolution with maximum labelling efficiencies, absolute measurements of protein copy numbers, precise multi-colour measurements, high - throughput for large scale statistics and novel data analysis approaches, to address the vast array of exciting biological questions at the nanoscale, which are becoming accessible only now.

«Simultaneous mutation detection, copy number measurement, and digital gene expression profiling of high - grade serous ovarian cancer FFPE samples using Hyb & SeqTM targeted sequencing technology»

In tumor samples, where we frequently encounter variants with a very small allele frequency due to contamination with normal tissue, copy number variation, and tumor heterogeneity, high coverage is essential for accurate detection of these variants with high power.

High gene copy number variation (CNV) among membrane - bound transporters, a class of proteins previously implicated in drug resistance, was found for the most highly differentially expressed genes.

These hotspots may be sites of selective susceptibility to double - strand - break damage due to high transcriptional activity or, through incrementally increasing copy number, may be sites of secondary selective pressure.

In this work we use high - resolution analysis of copy number, and analysis of segregation in trios, to define new, independent allelic series of amylase CNVs in sub-Saharan Africans, including a series of higher - order expansions of a unit consisting of one copy each of AMY1, AMY2A and AMY2B.

Not only do those eating vegetarian harbor more good bacteria, period; vegetarian fecal samples showed the highest number of copies of butyrate - producing genes.

Though more important than that is the fact Famitsu does track download cards (something neither Media Create or Dengeki do), and since the game did sell out at a few stores, this could have led a higher number of people to go for a download card instead of a retail copy.

Ford C - Max Energi: While the Fusion Energi posted a surprisingly high number of its own, the 988 C - Max Energis sold in June was even more significant... considering the non plug - in variant of the C - Mas only sold 1,952 copies.

It's common to set a number of steps with which the royalties escalate, setting a lower rate for the first 5,000 copies, a higher rate for the next 5,000, and only reaching the maximum rate after 10,000 or more copies have been sold.

If you're going to use your book as high - end marketing collateral, order a number of author copies to give away at conferences.

You make a good point about the 10,000 copies at $ 0.99 being quite different from the same number at a higher price bracket.

Most MG authors will tell you they sell as much (or more) in print as they do in ebook, but it's hard to move large numbers of print copies if you're not in bookstores (and with POD prices high relative to mass market print runs).

In an article for The Guardian, she spoke quite openly about her traditional publisher cutting the number of print copies produced for a subsequent book in her popular series, a fact she attributes to the high numbers of people who blatantly admit to her that they read pirated copies of her books.

«Unpaid royalties of approximately $ 7,300 because the publisher sold nearly 6,500 copies of a $ 17.99 hardcover edition at «high discount,» even though Agent Kristin had ensured that the author's contract limited the number of copies the publisher was allowed to sell at high discount.»

Culturally relevant titles is the number one need of teachers for their classroom libraries, followed closely by books published in the last 3 — 5 years, multiple copies of popular titles, high - interest, low - reading - level books, and magazines.

Often a bookstore will pay ahead and order a certain number of copies because that savings in shipping and a few percent higher in discount can make all the difference on staying alive.

For large numbers of copies, the per - unit costs for POD are higher than for press printing.

That's not to say that people won't shell out more for your books or that it's not worth pricing them higher in some instances, but you'll find that selling a larger number of copies becomes a lot easier within this affordable sweet spot.

To get a high quality self - published book, you should pay for general editing, structural editing, line editing, cover design, a barcode, and ISBN number, proof copies — all out of your own pocket.

The announcement follows a number of high - profile success stories in recent years: EL James's best - selling erotic novel 50 Shades of Grey began life as a self - published ebook, while thriller writer Rachel Abbott's first six self - published Kindle novels have together sold more than 2.5 million copies worldwide.

With no new sale, the sales rank will drift lower (to a higher number) as books that have sold copies push it down.

All dogs that are unfurnished (ff) do not need the furnishing test (since they carry 2 copies of the high shedding allele) and should automatically add 2 to the number of high shedding alleles identified with the Shedding locus 1 test.

Member tip: «Send a friendly message to members with a response rate higher than 80 % whose home corresponds with the the number of guests you will be traveling with and copy and paste your message to all members in the geographical area that interests you (you don't necessarily have to look at each specific profile).

I agree that the number should be higher on the physical copy reward, but it took them a while to add that option.

- 670,955 copies sold within its first three days - biggest debut for a Switch title - highest selling Switch title to date - number includes physical game copies, download cards, and Splatoon 2 Switch hardware bundles - does not include digital sales - Splatoon for Wii U sold 156,610 units within its first four days of release, and achieved lifetime sales of 1,512,789 units - total Switch hardware sales in Japan at 1,205,087

After selling 2 million copies in its first week of availability alone, the latest numbers from Square now place it behind Final Fantasy XIII as the second highest - selling game in the publisher's 2009 - 2010 fiscal year line - up: 4.26 million units.

Among that tot, Grand Theft Auto V holds an unbreakable record among all video game series of selling an incredibly high number of copies which is least 75 million copies.

Though more important than that is the fact Famitsu does track download cards (something neither Media Create or Dengeki do), and since the game did sell out at a few stores, this could have led a higher number of people to go for a download card instead of a retail copy.

While Jools Watsham of Atooi (formerly Renegade Kid) mentioned that Mutant Mudds Collection only sold «OK» with a cool 7,500 copies, other studios like Matt Makes Games (Celeste) and Team Meat (Super Meat Boy) have been screaming the Nintendo Switch's sales numbers from up high.

Steam sales alone show more than 2 million copies sold and retail numbers should bump this even higher.