Sentences with phrase «high cytotoxic»

At high cytotoxic concentrations, actinomycin D (ActD) blocks transcription, decreasing levels of MDM2 and thus causing p53 stabilization.

All extracts were found to have cytotoxic effects on the cancer cells, with the clove essential oil producing the highest cytotoxic effect.

Not exact matches

Conventional transplant conditioning employs radiation and / or high - dose cytotoxic drugs (also known as alkylators) to destroy the bone marrow and blood and immune cells; it also causes widespread cellular damage throughout the body.

Single - cell differential gene expression analysis revealed a spectrum of known transcripts, including several linked to cytotoxic and costimulatory function that are expressed at higher levels in the TEMRA (effector memory T cells expressing CD45RA) subset, which is highly enriched for CD4 - CTLs, compared with CD4 + T cells in the central memory (TCM) and effector memory (TEM) subsets.

Naïve T cells then expand and differentiate into effector T lymphocytes that acquire either cytotoxic activity or secrete high amounts of certain cytokines.

(PMID: 9802976) Download PDF [ii] Ogg GS, Rod Dunbar P, Romero P, Chen JL, Cerundolo V. High frequency of skin - homing melanocyte - specific cytotoxic T lymphocytes in autoimmune vitiligo.

Heretofore, treatment of patients with primary or light chain - associated (AL) amyloidosis has been directed toward reducing the synthesis of the amyloidogenic precursor protein through conventional or high - dose cytotoxic antiplasma cell chemotherapy.

Although no studies have directly confirmed its effect on breast cancer stem cells thus far, the outlook is positive that one day the connection may be made considering its cytotoxic effect on breast cancer cells, in general, has already proven to be so high.

Long - Term Intake of a Low - Casein Diet is Associated With Higher Relative NK Cell Cytotoxic Activity in F344 Rats.

The H2 concentration has been as high 98.87 percent H2 and 1.26 percent of O2, at 19.1 atm with minimal to no adverse or cytotoxic effects.