Sentences with phrase «high doses»

In an attempt to adhere to Caucasian beauty ideals, the researchers found, women of color are more likely to use chemical hair straighteners and skin lighteners, which disproportionately expose them to high doses of phthalates, parabens, mercury and other toxic substances.

Paul Ross, 60, has had 13 surgeries in the past 35 years, resulting in constant chronic pain and prescriptions for high doses of hydromorphone, which is used to treat severe pain that isn't controlled by other opioid drugs.

The c - MYC pathway appeared to some researchers to be an unlikely therapeutic target for beta cell regeneration because past studies had found it to cause beta cell death when activated in high doses.

But a main obstacle has been achieving stable silencing, so that the patient does not need to take repeated high doses of dsRNA.

«The evidence is clear that vitamin D toxicity is one of the rarest medical conditions and is typically due to intentional or inadvertent intake of extremely high doses,» writes Hollick, a professor of medicine, physiology and biophysics at Boston University School of Medicine.

When pregnant rats are exposed to high doses of phthalates, their male offspring are born with deformed genitalia.

«The advantage of being able to deliver methotrexate in this targeted way is to be able to gain the benefits from this key treatment of RA, while reducing the risk of adverse effects that are more frequent at high doses,» concluded Dr Macor.

After surgeons used radiation to burn away the tumor, she was switched to interleukin - 2, a naturally occurring protein that, in high doses, sends the body's immune defenses into overdrive.

«Existing radioprotectants have to be given in incredibly high doses,» she said.

To find out if tweaking current overdose protocols could prevent fatal liver damage, Duke mathematicians Lydia Bilinsky and Mike Reed and Duke biologist Fred Nijhout developed a mathematical model of acetaminophen metabolism, based on previous studies of lab rats given high doses of the drug.

In high doses, dioxins can disrupt fetal development and impair reproductive function — and dioxins are everywhere.

Hydrogen sulfide can be deadly in high doses.

All had persistent, moderate - to - severe asthma that was not well - controlled by medium to high doses of combined ICS and LABA therapy.

High doses of this compound, the antiseptic triclocarban, or TCC, impair reproduction in rats and may cause cancer in humans, but it's not clear whether the concentrations in fields — and presumably in food — are dangerous.

Experiments on rodents suggested that repeated high doses of alcohol destroy neurons in the hippocampus.

However, on page 1391 in this issue, Yun et al. (5) show that high doses of vitamin C selectively kill colorectal cancer cells carrying activating mutations in the oncogenes KRAS or BRAF, which are often refractory to approved targeted therapies.

Soybeans, corn and cotton that tolerate high doses of herbicides and fend off pests — technologies that benefit rich - world farmers — are nearly all the choices we have.

While it's clear that high doses of phthalates are harmful to animals, it remains to be shown whether these effects translate to humans.

«Only extremely high doses have been shown to provide some level of protection, but these doses are significantly higher than what is recommended in a vitamin supplement, and the safety of long term consumption of high doses of vitamin C and E is not known,» said Dr. Lim.

«High doses of vitamin D rapidly reduce arterial stiffness in overweight / obese, vitamin - deficient African - Americans.»

In that way, the small intestine shields the liver from dangerously high doses of fructose, says Joshua Rabinowitz, a metabolism researcher at Princeton University.

In the early 1970s, the two - time Nobel Prize — winning chemist Linus Pauling proposed that high doses of vitamin C (ascorbic acid) can act as an antioxidant to reduce cancer.

Over about 3.5 years, 535 of 3344 people in the placebo group suffered such an «event,» compared with 642 of 4547 getting the medium and high doses.

«We stress that this is a proof - of - concept study in which a form of tungsten, a heavy metal that is dangerous in high doses, was used.

Since it can be abused or toxic if taken in high doses, legal limits have been placed on its use, including requiring new users to report each day to a methadone clinic, and take the medication on site.

High doses of oral steroids over long periods are known to stunt children's growth — as does leaving asthma untreated.

Moreover, companies are moving into the use of new types of therapeutic proteins such as antibodies, which are only effective at high doses.

The addition of high doses of a form of vitamin A could help make chemotherapy more successful in treating pancreatic cancer, according to an early study by Queen Mary University of London (QMUL).

The effectiveness of leptin at battling diabetes in these animals may have been due to the high doses given, says Laura McCabe, a physiologist at Michigan State University in East Lansing.

Sustained, high doses of oral steroids are known to stunt children's growth — as does untreated asthma.

«However, even high doses of H1 antihistamine drugs aren't enough to alleviate the symptoms of some patients.

The researchers confirmed these findings in a mammary carcinoma mouse model — treatment with dasatinib just a few days after administering two high doses of chemotherapy prevented tumor growth and increased survival rates.

The HYPO - RT - PC trial, a randomized multi-institutional phase III trial in Scandinavia, was designed to assess outcomes from highly accelerated extreme hypofractionation, which is delivered in smaller number of high doses — seven fractions of 6.1 Gy each in this study.

In addition, a drug called dexrazoxane that could reduce cell damage has recently been approved for patients with metastatic breast cancer who receive high doses of doxorubicin.

Even more controversial for Somers and her many followers is that one of the sources interviewed in Ageless, T.S. Wiley, is pushing a treatment plan that may include alarmingly high doses of replacement hormones.

The results of the study, funded by the Malaria Eradication Scientific Alliance (MESA), are published in one of the world's leading medical journals The Lancet Infectious Diseases, and show that adding high doses of ivermectin, an endectocide class of drug, to the antimalarial dihydroartemisinin - piperaquine (DP) had a major and prolonged effect on mosquito mortality.

And more than two thirds of those patients are still receiving high doses of opioids from a month to three months after they overdose.

Triclosan is normally used externally and might be dangerous to swallow in high doses.

Washington's blood pressure was so high upon admission to Rockefeller Hospital — 225/145 mm Hg — that today's clinicians would treat it as an emergency, with high doses of medication.

Conventional radiation with photons gave way to intensity - modulated radiation therapy, or IMRT, in which more precise beams of photons could be moved dozens or hundreds of times with varying intensities, attacking tumors in three dimensions with safer high doses.

In the early 2000s, Johns Hopkins scientists Leo Luznik and Ephraim Fuchs found that giving patients high doses of cyclophosphamide — a drug derived from nitrogen mustard and used to treat blood cancers — three days after bone marrow transplant successfully thwarts acute and chronic GVHD.

Fewer veterans received prescriptions for risky dosages of opioid painkillers after a national initiative took aim at reducing high doses and potentially dangerous drug combinations, a new study finds.

The study may have people flocking to vitamin supplement aisles, but Lu stresses that the trial tested very high doses of vitamin D that far exceed daily allowances.

Transient liver toxicity is a significant concern in gene therapy, when high doses are required.

In addition, the high doses of antibiotics needed to kill such an infection indiscriminately destroy healthy red blood cells in addition to contaminated ones.

In fact, in this case, «antioxidants are preventing the health effects of exercise,» adds Ristow, although he cautions that not all vitamin supplements contain such high doses of vitamin C and E.

But the small viruses that deliver therapeutic genes can have adverse side effects at high doses.

He was not surprised to discover that male rats exposed to high doses of the chemical while in utero had lower sperm counts later in life.

«For example, in Alberta and Ontario, oxycodone is the drug most commonly prescribed at high doses, while in British Columbia, it's morphine.»

When people are exposed to high doses of this virus, they can succumb as well.