Sentences with phrase «high expression level of»

In five independent large cohorts in which more than 1100 total patients were followed for overall survival (Desmedt et al., 2007; Esserman et al., 2012; Kao et al., 2011; Pawitan et al., 2005; van de Vijver et al., 2002; Supplementary file 1), high expression level of MELK strongly correlated with increased rates of mortality (all p values < 0.05, hazard ratios > 2)(Figure 2D, Figure 2 — figure supplement 1D).

In cell culture, high expression levels of GPR161 induced proliferation of mammary epithelial cells, disrupted the acinar structures formed by these cells, and enhanced their invasive capacity.

In our study, morula stage parthenotes exhibited high expression levels of MEG3 and PEG1.

The high expression levels of two genes (DNMT3A and DNMT3B) related to DNA methylation in our study is also consistent with a mouse study showing the elevated methylation in parthenotes compared to IVF / ICSI embryos [39].

In multiple independent breast cancer cohorts analyzed, we found a strong association of high expression levels of MELK with a higher grade of malignancy and an unfavorable prognosis regardless of the treatment modality.

Not exact matches

The PRPA has already completed substantial pre-development work at the sites, improving access, in anticipation of private development spurred by a Request for Expressions of Interest (REI) that was issued late last year and, the port authority said, «garnered a high level of response from maritime industry, manufacturing, and energy companies.»

Allowing free - market expression of gold prices may have been seen as a serious risk at the highest policy levels.

The sociologist of religion will realize that it is rather a question of emphasis; individual expression and pecularity being present already on the level of so - called primitive civilization and communal worship playing a most important part in the highest forms of religion and culture.

Nonetheless, music, as literary and cultural critic George Steiner insists, «is brimful of meanings which will not translate into logical structures or verbal expression... Music is at once cerebral in the highest degree — I repeat that the energies and form - relations in the playing of a quartet, in the interactions of voice and instrument are among the most complex events known to man — and it is at the same time somatic, carnal and a searching out of resonances in our bodies at levels deeper than will or consciousness.»

Furthermore, the levels of Runx2 expression among a larger group of 351 newly diagnosed multiple myeloma patients were significantly higher in patients who had a high risk of early disease - related death, as compared with lower - risk patients.

The researchers» findings indicated that decreased pupil dilation to emotional facial expressions predicted a significant increase in post-flood depressive symptoms, but only among women who experienced higher levels of flood - related stress.

Remarkably, these brains showed higher levels of DCC expression — some 48 per cent higher when compared to control subjects.

When a single gene exists in the ancestral mutation, that would have made for higher levels of enzyme expression, would have messed up with sensory function.

They found higher levels of JAK1 in resistant tumors, which caused increased expression of epidermal growth factor receptor (EGFR)-- a receptor tyrosine kinase that promotes cell proliferation.

Single - cell differential gene expression analysis revealed a spectrum of known transcripts, including several linked to cytotoxic and costimulatory function that are expressed at higher levels in the TEMRA (effector memory T cells expressing CD45RA) subset, which is highly enriched for CD4 - CTLs, compared with CD4 + T cells in the central memory (TCM) and effector memory (TEM) subsets.

Researchers also found higher levels of expression of the gene MET, which is linked to autism spectrum disorder, in the human prefrontal cortex compared to the other primates tested.

In clinical samples of high - grade gliomas from patients, the expression levels of both FOXD1 and ALDH1A3 were inversely correlated with disease progression — gliomas with high levels were more rapidly fatal than were gliomas with low levels.

Expression of a liver protein (Cytochrome P450 26A1) that regulates levels of retinoic acid — a by - product of vitamin A — was higher in the sufficient group.

But new research presented today at the American Physiological Society (APS) annual meeting at Experimental Biology 2017 in Chicago suggests that normal levels of vitamin A within a high - fat diet can negatively affect expression of liver genes associated with glucose and fat metabolism.

They also stressed that IL - 6's role in inflammation «extends well beyond the immune system and the kidney, with high levels of expression in atherosclerotic plaques and elevated serum levels being associated with increased coronary artery disease and morbidity from hypertension, left ventricular hypertrophy, and development of insulin resistance.»

Through analyzing several datasets of prostate cancer cases and patient outcomes, the researchers found that a high level of expression of two genes, TOP2A and EZH2, was associated with early recurrence of prostate cancer and metastatic spread, leading to an increased risk of death.

The SPFES is a tool to measure pain levels based on facial expressions of sheep, and has been shown to recognise pain with high accuracy.

In a study recently published in the journal Experimental Haematology, the group demonstrate that is wide variation in BCR - ABL expression levels in the cell model and the stickier cells have a higher level of BCR - ABL expression.

The study showed that TNBC patients whose tumours have high expression of RASAL2 tend to have a lower survival rate as compared to patients whose tumours have low levels of this gene.

«The high level of CIRPB expression found in the developing ovaries of marine turtle hatchlings and post-hatchlings also supports our hypothesis that CIRBP may play a role in the molecular pathways of sexual differentiation in marine turtles,» said Tezak.

Previous studies have shown a physiologic role for vitamin D in liver function, but «it was our discovery of high levels of vitamin D receptor (VDR) in the stellate cell that led us to consider it as a possible off switch for liver fibrosis,» says lead author Ning Ding, a research associate in the Gene Expression Laboratory.

Using this approach, these investigators found that nodes (genes) with high connectivity tend to have lower levels of change in expression than peripheral nodes, consistent with the notion that disease ‐ causing genes are typically not central hubs in a molecular module.

The VHH is the total antigen binding domain or active site of these single - headed immunglobulins (IgG) and llama antibodies have been studied in this single domain form due to the dual advantages of bacterial / yeast expression and their high levels of thermal and pH stability [28].

In addition, gastrocnemius muscles from IL - 15Rα — KO mice expressed higher levels of mRNA for the sarcoplasmic endoplasmic reticulum calcium ATPase - II (SERCA2) and lower mRNA expression and protein content of the calcium - binding protein calsequestrin (Figure 5, F and G).

The highest level of expression was found in heart and bladder endothelial cells.

In prediabetes or diabetic conditions, the serum IAPP levels may be substantially higher because insulin resistance promotes greater expression of insulin and IAPP.

A few studies have suggested that CA2 might be involved in social memory, as this region has a high level of expression of a receptor for vasopressin, a hormone linked to sexual motivation, bonding, and other social behaviors.

After a planarian is wounded, the type of injury determines the level fst expression ---- the more extreme the loss of tissue, the higher the level of fst expressed.

Ectopic expression of KLF4 alone in 231BrM did not affect the primary tumor growth in vivo and this is due to the fact that the endogenous level of KLF4 in 231BrM cells is already quite high.

However, its extreme length (> 13kb), number of exons (> 50) and high level of alternative splicing means CACNA1C isoform structure and expression is poorly understood, making it difficult to identify which gene isoforms confer disease risk and where they are expressed.

(C) Time course of Acks expression level investigated by quantitative RT - PCR after seizure induction under the high temperature (46 °C).

Dr. Moscat's laboratory, in collaboration with that of Dr. Karin at UCSD, has established for the fist time that p62 is necessary and sufficient for HCC induction in mice and that its high expression level in non-tumor human liver predicts rapid HCC recurrence after curative ablation.

High level of cell surface CD4 expression.

High mRNA expression levels of HNF4α and ASGPR1 are shown in the enhanced hiPS - HEP cells for an extended culture time and are comparable to levels in cryopreserved human primary hepatocytes (hphep cells) that have been grown for only a short time.

If, for instance, a researcher finds that dozens of genes in a microarray are differentially expressed on a high - fat purified ingredient diet compared to a low - fat GB diet, it is tempting to conclude that gene expression was altered due to the differences in fat levels between the diets.

BTHP - 1 parental cells were transduced with the MLV vector MX - DC - SIGN and FACS sorted as a population for high levels of DC - SIGN expression.

CR increases the expression levels of SIRT1 7, 8, SIRT3 9 and SIRT5 10, while high fat diet has been demonstrate to reduce SIRT1 expression 11.

In the 1980s, Dr. Kaufman's experience with gene transfer and engineering led him to become a founding scientist at Genetics Institute Inc., where he engineered mammalian cells for high - level expression of therapeutic proteins, such as clotting factors that are now used to treat individuals with hemophilia.

High - level expression can result under inflammatory and tolerogenic conditions in vivo, and OX40 can be maintained for a number of days under adjuvant - induced inflammatory conditions.

When BubR1H / H; INK - ATTAC mouse bone marrow cells were pushed into senescence in vitro by the PPAR - γ - activating drug rosiglitazone, a subpopulation of the cells exhibited high levels of INK - ATTAC expression and GFP, coupled with SAβ - gal staining; subsequent to treatment with the INK - ATTAC activating drug, these cells rapidly entered into apoptosis, and within 48 h were either destroyed or in the cell death process.

PCR then demonstrated high levels of anti ‐ HIV gene expression and a significant downregulation of CCR5 expression.

Sustained high - level expression of human factor IX (hFIX) after liver - targeted delivery of recombinant adeno - associated virus encoding the hFIX gene in rhesus macaques.

In comparison, mouse NSCs were reported to express twofold higher levels of Sox2, an eightfold lower level of Klf4, and a tenfold higher level of c - Myc expression relative to mouse ESC expression levels [14].

Dr Gilchrist said: «This study suggests that we may improve significantly on the widely used analysis methods for determining gene expression levels from high throughput sequence data: absolute quantitation offers a much sounder basis for determining changes in gene expression level, a measure widely used to determine the consequence of genetic, chemical or physical disturbances in living systems.»

Since we know the Gal4 - UAS system is sensitive to temperature and in fact, expression levels of these transgenes differ at 22 °C and 25 °C, Drosophila GBPs might also suppress ILP secretion from the insulin - producing cells when expressed at high concentrations.