Sentences with phrase «high expression levels»

In multiple independent breast cancer cohorts analyzed, we found a strong association of high expression levels of MELK with a higher grade of malignancy and an unfavorable prognosis regardless of the treatment modality.
«What caught my attention about autoimmunity and specifically lupus,» Anguera said, «was that there were genes on the X chromosome that were immunity related and that had been shown to have higher expression levels in lupus patients.»
Western blot analysis showed high expression levels of all mTOR signaling proteins in both untreated ALCL cell lines.
Additional analysis showed that many inflammatory genes had higher expression levels in Western diet than control diet - fed FXR KO mice after Abx treatment.
Genes with high expression levels are clustered in genomic regions known as ridges.
In five independent large cohorts in which more than 1100 total patients were followed for overall survival (Desmedt et al., 2007; Esserman et al., 2012; Kao et al., 2011; Pawitan et al., 2005; van de Vijver et al., 2002; Supplementary file 1), high expression level of MELK strongly correlated with increased rates of mortality (all p values < 0.05, hazard ratios > 2)(Figure 2D, Figure 2 — figure supplement 1D).
In cell culture, high expression levels of GPR161 induced proliferation of mammary epithelial cells, disrupted the acinar structures formed by these cells, and enhanced their invasive capacity.
Tissues with the highest expression level for each candidate were normalized to a relative value of 1.0.
Values were normalized to the 0 time point and to tissues with the highest expression levels.
Dr. Moscat's laboratory, in collaboration with that of Dr. Karin at UCSD, has established for the fist time that p62 is necessary and sufficient for HCC induction in mice and that its high expression level in non-tumor human liver predicts rapid HCC recurrence after curative ablation.
In rostral brain regions, high expression levels in the dorsal lateral striatum, while in the caudal brain regions, high levels are observed in the ventral lateral striatum (PubMed: 10891614).
Again, high expression level of MELK robustly correlates with metastasis in breast cancer patients (both p values < 0.001, hazard ratios > 2; Figure 2C).
532 genes have been categorised as housekeeping because of their ubiquitous and high expression levels in 47 tissues.
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