Previous studies have shown an association between
high folic acid intake and a reduction in the immune system defenses needed to fight viral infections and cancer.
Their study in aged mice indicates that
high folic acid intake causes lowered immune function because natural killer (NK) cells, a particular type of immune cell, are less effective.
«
High folic acid intake in aged mice causes a lowered immune response.»
Not exact matches
MTHFR + / + or + / - pregnant mice on a control diet or
folic acid - supplemented diet (20-fold
higher than the recommended
intake) were examined for embryonic loss, delay, and defects.
You may have already started to take
folic acid, but your doctor might recommend a
higher intake.
A treatment group of mice were given an
intake of
folic acid 20 times greater than the RDA for humans: while the
folic acid dosage consumed by most adults is lower and taken over a longer period of time, a
higher dose was used in this study to account for the fact that mice are more efficient in metabolizing
folic acid than humans.
The low activity of this enzyme in the human liver, combined with a
high intake of
folic acid, may result in unnatural levels of unmetabolized
folic acid entering the systemic circulation.
It is my opinion that the
higher cancer incidence found in those with increased serum vitamin D levels was due in part to confounding by health oriented behavior that was no accounted for in adjustments for relative risk, including (1) decreased
intake of vitamin K2 due to avoidance of saturated fat and particularly to avoidance of cheese (2) increased
intake of N - 6 fats in accordance with USDA recommendations thereby increasing risk of prostate cancer (see PMID 20693267) and (3) increased
intake of supplements such as
folic acid which increases prostate cancer risk (PMID 19276452)
People aged 50 years and older have the
highest total folate
intakes and about 5 % have
intakes exceeding the UL of 1,000 mcg per day, primarily due to
folic acid from dietary supplements [17].
Increased
intake of
folic acid: Eating foods
high in folate may help lower the risk for breast cancer, especially in women who consume alcohol.