Sentences with phrase «high genetic risk for»

A study led by Massachusetts General Hospital investigators has found that, even among those at high genetic risk for heart disease, following a healthy lifestyle can cut in half the probability of a heart attack or similar event.

Keeping fit, even if you're born with a high genetic risk for heart disease, still works to keep your heart healthy, according to a study led by researchers at the Stanford University School of Medicine.

Male teens who experiment with cannabis before age 16, and have a high genetic risk for schizophrenia, show a different brain development trajectory than low risk peers who use cannabis.

«Cannabis use may influence cortical maturation in adolescent males:... who have a high genetic risk for schizophrenia.»

«Depressed patients with earlier and more severe symptoms have high genetic risk for major psychiatric disorders.»

Researchers used accelerometers to measure the daily physical activity of participants, all of whom are in late middle - age and at high genetic risk for Alzheimer's disease, but presently show no cognitive impairment.

Of all four groups studied, only those at high genetic risk for Alzheimer's who did not exercise experienced a decrease in hippocampal volume (3 %) over the 18 - month period.

The researchers found strong evidence that people with higher genetic risk for several mental disorders — including schizophrenia, and to a lesser extent bipolar and major depressive disorder — are also at higher genetic risk for developing PTSD after a traumatic event.

«This work highlights the importance of severe environmental stressors in the development of suicide attempts in those at higher genetic risk for bipolar disorder.»

Not exact matches

While GMOs are banned from foods certified organic (like MELT Organic), USDA enforcement on genetic testing is lacking for verifying non-GMO status with high risk ingredients (e.g., canola, corn, soy, alfalfa, sugar beets, zucchini, cotton, etc.) whose organic seed may have been contaminated by neighboring farms.

However, this study only included kids at high - risk for celiac (based on genetic markers or a first - degree relative with the disease), so it might not apply to the general population.

But the fact is something in the genetic make up and hormones of baby boys expose them to a higher risk of autism than girls (for those who can not sleep without knowing so those weird medical terms, girls tend to have lower levels of vasopressin and higher levels of natural oxytocin).

Individuals were classified as high risk for Alzheimer's if a DNA test identified the presence of a genetic marker — having one or both of the apolipoprotein E-epsilon 4 allele (APOE - e4 allele) on chromosome 19 — which increases the risk of developing the disease.

The authors searched for genetic mutations that might explain the disproportionately high risk of SUDEP in people with poorly controlled focal epilepsy, which, by definition stems from a specific area of the brain.

«The type of inflammation seen in psoriasis is known to promote insulin resistance, and psoriasis and diabetes share similar genetic mutations suggesting a biological basis for the connection between the two conditions we found in our study,» said the study's senior author Joel M. Gelfand, MD MSCE, a professor of Dermatology and Epidemiology at Penn. «We know psoriasis is linked to higher rates of diabetes, but this is the first study to specifically examine how the severity of the disease affects a patient's risk.»

Genetic alterations that can be modulated by stress have been identified in children at high risk for bipolar disorder, according to a recently published study by researchers at McGovern Medical School at The University of Texas Health Science Center at Houston (UTHealth).

One known miR - 182 target is CHEK2, a known tumor suppressor and suspected genetic risk factor for high - tension glaucoma.

According to the paper, this is one of the first times an oral biologic has been used successfully to change the natural history of a genetic disease; in this case, a mutation that puts individuals at very high risk for colon cancer.

Thus, this single genetic test can indicate a risk for bipolar illness that is 20-fold higher than that of the general population.

Led by Brenda Penninx, PhD, of the VU University Medical Center in Amsterdam, the Netherlands, the study found that patients with an early age at onset and higher symptom severity have an increased genetic risk for MDD, bipolar disorder and schizophrenia.

Women with a family history of two or more immediate family members (mother, sister, daughter) with breast or ovarian cancer or with a positive genetic test for mutations in the BRCA1 or BRCA2 genes may be advised to consider having both breasts removed, because they are at high risk of a new cancer developing in the other breast.

Using an independent group of 1602 MDD patients and 1390 control participants from the RADIANT - UK study, the researchers also replicated their finding that patients with a high number of DSM symptoms have increased genetic risk for schizophrenia.

NIPD for single gene disorders in a fetus is diagnostic, as it targets specific genetic changes present in a high risk family.

People who identify as African American, for example, are as a group at higher risk for disorders that do have a genetic component, such as hypertension and diabetes.

Using next - generation sequencing (NGS) technology, researchers were able to pinpoint specific areas of a person's DNA to more effectively diagnose genetic forms of high - cholesterol, which markedly increase risk for heart attack and stroke.

Individuals who are a very high genetic, maybe even epigenetic, risk for addiction, but who are never exposed to a drug of abuse, that would simply remain a latent risk never expressed.

«For the future,» she added, «might we match donors and recipients based on genetic factors, or consider fertility preservation for women with a high risk of premature ovarian failure?&raqFor the future,» she added, «might we match donors and recipients based on genetic factors, or consider fertility preservation for women with a high risk of premature ovarian failure?&raqfor women with a high risk of premature ovarian failure?»

A test based on the genetic make - up of the Barrett's lesions could benefit patients through improved diagnosis, giving people at high risk of cancer the best care, and reducing the burden of endoscopy for those at low risk.

Hereditary predisposition to cancer is sometimes due to a single high - risk genetic change, like a mutation in the BRCA1 or BRCA2 genes for breast cancer, but most of the time, the disease is the result of multiple gene variants that add up, environmental risk factors, and a big element of chance.

It also confers the highest - known genetic risk for schizophrenia.

«Genetic mutations warn of skin cancer risk: New high - risk cancer causing mutation identified for melanoma development.»

If anything — contrary to Lichtenstein's conclusions — the genetic risk was higher for rarer cancers, Risch reports in the July issue of Cancer Epidemiology, Biomarkers & Prevention.

The team found that genetic variants that contribute to higher scores on the Eyes Test also increase the risk for anorexia, but not autism.

Still, many scientists have hoped that once they found all the genetic markers for a disease, including rare ones that confer higher risk, the total risk carried by some individuals would be high enough — say, two times the normal risk — to merit taking preventive measures.

[These diseases pose] a high enough risk that it falls squarely within a medical model of the use of preimplantation genetic diagnosis,» unlike screening for sex or cosmetically desirable traits, he says.

«If we can identify similar genetic loci in people, and if we could find biomarkers for these gene - environment interactions, then perhaps we could develop a simple blood test that identifies people who are at high risk of cancer from low - dose radiation,» says Mao.

Our study, along with prior studies, supports the notion that «cognitive reserve» resulting from early - life and lifelong education and cognitive stimulation may be a potent strategy for the primary prevention of dementia in both high - and low - income countries around the world.21 However, it should be noted that the relationships among education, brain biology, and cognitive function are complex and likely multidirectional; for instance, a number of recent population - based studies have shown genetic links with level of educational attainment, 22,23 and with the risk for cognitive decline in later life.24 Higher levels of educational attainment are also associated with health behaviors (eg, physical activity, diet, and smoking), more cognitively - complex occupations, and better access to health care, all of which may play a role in decreasing lifetime dementia risk.

The current study focused on the genetic pathways that cause a rare genetic disease called Li - Fraumeni Syndrome or LFS, which comes with high risk for many cancers in affected families.

HOUSTON --(May 8, 2017)-- Genetic alterations that can be modulated by stress have been identified in children at high risk for bipolar disorder, according to a recently published study by researchers at McGovern Medical School at The University of Texas Health Science Center at Houston (UTHealth).

We predicted that MP's behavioral effects in marijuana abusers would be attenuated, consistent with preclinical findings (30), and that decreased DA reactivity in ventral striatum would be associated with higher scores in negative emotionality (neuroticism), which mediates genetic risk for marijuana dependence (31), and with addiction severity.

Testing for these variants combined with all 21 previously identified using genetic sequencing identified men with a 10-fold higher risk of testicular cancer than the population average.

This evidence suggests that people with high - genetic risk for schizophrenia - spectrum disorders receive a protective effect of the healthy family environment of 86 % decrease in risk.

Similar issues could arise from the ability to identify people at a higher risk for contracting or spreading a disease using human genetic markers.

The key factor: Nearly half of the patients considered at high risk for recurrence might actually be low risk based on genetic factors, researchers found.

In both situations, the provisions of GINA may limit the ability to use genetic information to determine which employees would be most appropriate for high - risk job placements in case of an infectious disease outbreak.

The first is that the Finnish national database that was consulted for sampling purposes is so extensive that they were able to find adoptees and families at high - and low - genetic risk for schizophrenia - spectrum disorders that were matched on demographic variables (age, education, income level, household size, etc.).

Adoptees with high - genetic risk for schizophrenia - spectrum disorders (see below) have been found to be more sensitive to environmental effects than adoptees with low - genetic risk for the disease.

The Clinical Cancer Genetics Program coordinates genetic testing and high - risk cancer surveillance for individuals and their families with hereditary cancer syndromes.

This means that adoptees with high - genetic risk for schizophrenia - related disorders did not have any measurable impact on parental communication and care giving skills, or on the functioning of the rest of the family, according to the OPAS rating system that was used to evaluate the families in the study.

Genetic counseling is an option for women who are not personally affected by breast cancer but have a significant family history of breast cancer or have other factors that put them higher risk for developing the disease.