Sentences with phrase «high genetic risk of»
In a birth cohort study, risk of psychosis in adulthood was raised by a factor of 4 if the mother, during pregnancy, reported that a baby was unwanted.49 Separation from parents in early life has been found to predict an increased risk of psychosis in genetically vulnerable children, 50,51 and the association between immigrant status and severe mental illness may be at least partially explained by the high rates of early separation in migrant populations.52 Adolescents at high genetic risk of psychosis have also been found to be at increased risk of psychosis in later life if they report adverse relationships with their parents.53
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This is especially likely to be the case if, in the absence of well - developed ToM skills, the individual is unable to attribute the negative actions of others to situational factors.137 (Consistent with this part of this model, a genetic high - risk study has reported that, in adolescents at high genetic risk of psychosis, an external locus of control predicted the later development of illness.142) These characteristics will, in turn, lead to a tendency to anticipate social threats and hence paranoid beliefs.
Assessing the usefulness of a novel MRI - based breast density estimation algorithm in a cohort of women at high genetic risk of breast cancer: the UK MARIBS study
About 30 percent of cases involved risk - reducing mastectomy in women at high genetic risk of breast cancer.
A planned clinical trial in people with high genetic risk of developing Alzheimer's will put the amyloid hypothesis to the test yet again
Not exact matches
Genetic meaning that maybe she has a personal history of mental illness or a family history of mental illness, she might be at higher biological risk because she might be an older mother, maybe has gone through infertility, pregnancy loss maybe she has multiples.
Many of the women that we seen are practice since we do more high risk and our patients that are coming from the infertility doctors and so, sometimes these patients have already had a pre-implantation genetic testing.
But the fact is something in the genetic make up and hormones of baby boys expose them to a higher risk of autism than girls (for those who can not sleep without knowing so those weird medical terms, girls tend to have lower levels of vasopressin and higher levels of natural oxytocin).
Results were similar in analyses of sleep patterns; among participants with some genetic risk of obesity, those who woke up frequently or slept more restlessly had higher BMIs than those who slept more efficiently.
(1) These regulatory thresholds reflect a decline in sperm quality with age and the greater likelihood of DNA mutations and higher risk of genetic abnormality in offspring.
Individuals were classified as high risk for Alzheimer's if a DNA test identified the presence of a genetic marker — having one or both of the apolipoprotein E-epsilon 4 allele (APOE - e4 allele) on chromosome 19 — which increases the risk of developing the disease.
Of all four groups studied, only those at high genetic risk for Alzheimer's who did not exercise experienced a decrease in hippocampal volume (3 %) over the 18 - month period.
Some have a higher risk of cardiovascular disease or diabetes, which is due both to lifestyle - related risk factors (such as eating unhealthily, smoking, being overweight and not taking enough exercise) as well as genetic predisposition (such as diabetes mellitus in migrants from Pakistan).
The authors searched for genetic mutations that might explain the disproportionately high risk of SUDEP in people with poorly controlled focal epilepsy, which, by definition stems from a specific area of the brain.
Researchers used accelerometers to measure the daily physical activity of participants, all of whom are in late middle - age and at high genetic risk for Alzheimer's disease, but presently show no cognitive impairment.
«The type of inflammation seen in psoriasis is known to promote insulin resistance, and psoriasis and diabetes share similar genetic mutations suggesting a biological basis for the connection between the two conditions we found in our study,» said the study's senior author Joel M. Gelfand, MD MSCE, a professor of Dermatology and Epidemiology at Penn. «We know psoriasis is linked to higher rates of diabetes, but this is the first study to specifically examine how the severity of the disease affects a patient's risk.»
Genetic alterations that can be modulated by stress have been identified in children at high risk for bipolar disorder, according to a recently published study by researchers at McGovern Medical School at The University of Texas Health Science Center at Houston (UTHealth).
The clinic monitors people who are already at high risk of pancreatic cancer due to family history or having known risk - raising genetic mutations.
According to the paper, this is one of the first times an oral biologic has been used successfully to change the natural history of a genetic disease; in this case, a mutation that puts individuals at very high risk for colon cancer.
«We believe that individuals born with this genetic mutation and who are later exposed to MAP through consuming contaminated milk or meat from infected cattle are at a higher risk of developing rheumatoid arthritis,» Naser said.
Spotting the bits of mutant DNA that underlie Alzheimer's may soon lead to genetic tests that can tell whether someone is at higher risk so he or she can take preventive steps.
The group has also shown that in humans, genetic variants of the Oprl1 gene are associated with higher risk of developing the disorder after exposure to trauma.
Thus, this single genetic test can indicate a risk for bipolar illness that is 20-fold higher than that of the general population.
Led by Brenda Penninx, PhD, of the VU University Medical Center in Amsterdam, the Netherlands, the study found that patients with an early age at onset and higher symptom severity have an increased genetic risk for MDD, bipolar disorder and schizophrenia.
Women with a family history of two or more immediate family members (mother, sister, daughter) with breast or ovarian cancer or with a positive genetic test for mutations in the BRCA1 or BRCA2 genes may be advised to consider having both breasts removed, because they are at high risk of a new cancer developing in the other breast.
Women who have a genetic mutation face a higher risk of developing a second breast cancer and may wish to consider more aggressive treatment, preventive measures or additional screening.
The National Institutes of Health - funded study, published July 2 in the New England Journal of Medicine, also found that participants in Sweden had higher rates of celiac disease than participants in the United States, Finland and Germany, even with the same genetic risks.
Using an independent group of 1602 MDD patients and 1390 control participants from the RADIANT - UK study, the researchers also replicated their finding that patients with a high number of DSM symptoms have increased genetic risk for schizophrenia.
«This test will help to determine whether an individual is at high risk of developing liver fibrosis, or whether a patient's liver disease will progress rapidly or slowly, based on their genetic makeup.
The inherited component of breast cancer risk is due to a combination of rare variants in genes such as BRCA1 and BRCA2 that confer a high risk of the disease, and many commoner genetic variants that each confer only a small risk.
«In the absence of a documented high - risk genetic variant, bilateral oophorectomy before the age of 50 years (or before menopause) is never to be considered and should not be offered as an option to women.»
Using next - generation sequencing (NGS) technology, researchers were able to pinpoint specific areas of a person's DNA to more effectively diagnose genetic forms of high - cholesterol, which markedly increase risk for heart attack and stroke.
Individuals who are a very high genetic, maybe even epigenetic, risk for addiction, but who are never exposed to a drug of abuse, that would simply remain a latent risk never expressed.
Should the results be confirmed by further studies, it is possible that patients with certain genetic changes in BRCA1 could be identified as being at higher risk of breast and ovarian cancer.
«For the future,» she added, «might we match donors and recipients based on genetic factors, or consider fertility preservation for women with a high risk of premature ovarian failure?»
«Genetic risk factors may be more fully expressed in environments with low parental monitoring and high alcohol availability, and the presence of friends, particularly close friends, who drink.»
A test based on the genetic make - up of the Barrett's lesions could benefit patients through improved diagnosis, giving people at high risk of cancer the best care, and reducing the burden of endoscopy for those at low risk.
Their quality of life suffered too, as those with higher genetic risk missed work and school more often and were more often admitted to the hospital because of asthma.
The results validated a previous group's discovery that measurement of the genetic diversity between Barrett's cells in any given lesion is a good predictor of which patients are at high risk of developing cancer.
Hereditary predisposition to cancer is sometimes due to a single high - risk genetic change, like a mutation in the BRCA1 or BRCA2 genes for breast cancer, but most of the time, the disease is the result of multiple gene variants that add up, environmental risk factors, and a big element of chance.
A tool intended to detect signs of autism in high - risk infants can be used to help identify and treat patients with tuberous sclerosis complex (TSC), a genetic disorder, who most need early intervention.
«Genetic mutations warn of skin cancer risk: New high - risk cancer causing mutation identified for melanoma development.»
«This study demonstrates that a high - risk social environment can overwhelm the protective effect of a genetic variant associated with alcohol - related behaviors,» said Emily Olfson, an MD - PhD student at Washington University School of Medicine as well as first author of this study.
«New tumor analysis method identifies high - risk prostate cancer: Cancer cells» genetic pathways show which patients are likely to develop aggressive types of the disease.»
Yesterday Angelina Jolie shared her experience as a carrier of a BRCA1 genetic mutation that confers a very high lifetime risk of developing invasive breast cancer.
Across all three prospective studies, a higher genetic risk score significantly increased the incidence of coronary events — as much as 90 percent in those at highest risk.
Within each genetic risk category, the presence of lifestyle factors significantly altered the risk of coronary events to such an extent that following a favorable lifestyle could reduce the incidence of coronary events by 50 percent in those with the highest genetic risk scores.
«Now, using a genetic approach, researchers at the University of Leicester undertaking the study on behalf of an international consortium of scientists (the CADIoGRAM + C4D consortium) have shown that the association between shorter height and higher risk of coronary heart disease is a primary relationship and is not due to confounding factors.»
ApoB backers point to recent analyses that found high apoB levels better predicted patients» likelihood of suffering a heart attack or stroke and a genetic study that showed that reducing apoB had a bigger effect on cardiovascular risk than did reducing LDL cholesterol.
Each of the genetic variants studied by the researchers is a single - nucleotide polymorphism, or SNP — a site at which the DNA code is altered by a single «letter» or nucleotide in some individuals, and where one «letter» is more commonly found in individuals with higher fracture risk.