Sentences with phrase «high grade tumors»

Because gadolinium is larger than glucose it only detects 70 to 80 percent of high grade tumors — those with major disruption of the BBB, i.e. with holes large enough for gadolinium to penetrate.

Prudent and Mediterranean dietary patterns showed different effects in low and high grade tumors.

Because the highest grade tumors cause the most disruption of the BBB, the rate of movement of the contrast agent through the barrier is a strong indication that a tumor is high grade.

When compared with MRI scans using the metallic enhancing agent gadolinium, DGE - MRI gave comparable results - showing details of brain structure and areas where tumors had disrupted the blood - brain barrier (BBB), which is a hallmark of the highest grade tumors.

Higher grade tumors correlate with higher restricted water volume in the cancer cells» large nuclei.

Chemotherapy may be recommended for patients with more aggressive tumors (e.g. higher grade tumors).

Not exact matches

In 2009 he had been diagnosed with a type of rapidly growing brain tumor called a high - grade astrocytoma that, despite aggressive treatment, eventually evolved into a glioblastoma — the highly malignant brain tumor that also took the lives of Vice President Joe Biden's son, Beau, in 2015 and former Sen. Ted Kennedy in 2009.

«Animal studies and in - vitro studies with human cells have repeatedly shown that food - grade carrageenan causes gastrointestinal inflammation and higher rates of intestinal lesions, ulcerations, and even malignant tumors.»

A high degree of aneuploidy is a feature of high - grade tumors and is associated with poor prognosis.

«This indicates that therapies for high - grade gliomas should be personalized, that is, based on the tumor subtype instead of applying one treatment to all patients,» he says.

For this study, Nakano and his collaborators used cancer cells from 40 patients with high - grade gliomas, focusing on tumor cells with a stem - cell signature.

Importantly, elevated BRCA1 methylation was confined to patients diagnosed with so - called high - grade serous tumors, the most aggressive variant of ovarian cancer, which also is the variant associated with BRCA1 mutations.

A section of a tumor organoid grown from cells derived from a patient with high - grade serous ovarian cancer (left) and a mini-tumor treated with ReACp53, resulting in extensive cancer cell death.

But mutations, which are found in 96 percent of patients with high - grade serous ovarian tumors, can cause p53 to form clumps, or «aggregates,» which impair the protein's normal function.

Similar to high - grade gliomas, which originate in the brain, these metastatic brain tumors are lethal, and there are very few therapeutic options.

«We think that by isolating the CA125 - negative tumor cells we have uncovered this reservoir of carboplatin - resistant high - grade serous ovarian cancer cells.»

More activity of the neuroligin - 3 gene in high - grade gliomas was linked to shorter survival among patients with these tumors.

The tumors studied fell into the broad category of high - grade gliomas: diffuse intrinsic pontine glioma, which strikes school - aged children; pediatric cortical glioblastoma, which affects primarily teens and young adults; anaplastic oligodendroglioma, which affects young adults; and glioblastoma multiforme, which affects older adults.

They then conducted biochemical analyses to identify neuroligin - 3, confirm that the protein could stimulate tumor growth in cultured samples of several kinds of human high - grade gliomas and study which signals the protein uses within glioma cells to promote their growth.

Deadly brain tumors called high - grade gliomas grow with the help of nerve activity in the cerebral cortex, according to a new study by researchers at the Stanford University School of Medicine.

The disorder, marked initially by benign tumors on nerves, often leads to brain cancer, and although most NF1 - related malignancies are nonaggressive, a fraction are «high - grade» and difficult to treat, experts say.

The presence of both factors occurred in seven of 12 patients with high - grade tumors but only two of 14 with low - grade cancers.

It was also associated with higher tumor grades and predicted worse survival.

«This is exciting because it's the first animal model of pediatric high - grade gliomas, or malignant brain tumors,» says Maria Castro, Ph.D., senior author of the paper and a professor in the departments of Neurosurgery and Cell and Developmental Biology at U-M.

For a majority of patients diagnosed with aggressive, high - grade tumors with metastases, the five - year survival rate is about 16 percent, though chemotherapy has been associated with an improvement in survival, and new targeted agents are being tested.

These data suggest that some high grade endometrioid tumors have developed a strikingly similar pattern of alterations to serous tumors, and may benefit from a similar course of treatment.

Grade IV (high - grade): Grade IV tumors are the most aggressive.

Screening of several other pediatric brain tumors revealed that the histone H3 mutations seem exclusive to pediatric high - grade gliomas.

St. Jude Children's Research Hospital - Washington University Pediatric Cancer Genome Project offers new leads to improved outcomes for children with high - grade glioma brain tumors; particularly youngest patients

The inclusion of tumors is based on availability and representativity, however, an effort has been made to include high and low grade malignancies where such is applicable.

The current standard of care for a newly diagnosed, high - grade glioma includes surgically removing as much of the tumor as possible, followed by radiation therapy and chemotherapy.

Increased expression of inflammatory cytokines correlates with higher tumor grade, greater metastatic potential, and higher incidence of resistance to treatment, all of which predict a poorer survival.

Research from the Pediatric Cancer Genome Project has identified new mutations in pediatric brain tumors known as high - grade gliomas, including tumors like diffuse intrinsic pontine glioma pictured in this MRI.

The St. Jude Children's Research Hospital - Washington University Pediatric Cancer Genome Project has identified new mutations in pediatric brain tumors known as high - grade gliomas (HGGs), which most often occur in the youngest patients.

Association and prognostic significance of BRCA1 / 2 - mutation status with neoantigen load, number of tumor - infiltrating lymphocytes and expression of PD - 1 / PD - L1 in high grade serous ovarian cancer.

The authors showed that MELK expression is higher in high - grade breast cancers (Figure 2B), thus it is not clear whether MELK expression is higher in in BCC because there are more high - grade tumors in the BCC sub-types than the other 4 sub-types in the dataset used for the analysis.

Seeking medical help when a tumor is larger, higher grade, and / or with more lymph nodes involved can dramatically lower a woman's odds for survival.

Five - year survival rates for low - grade (grade 1) tumors can be as high as 95 percent; for grade 4 tumors, five - year survival plummets to about 5 percent, she said.

Children with high - grade tumors (grades III and IV) tend to do better than adults; five - year survival for children is about 25 %.

The tumor did get graded a high Grade 2, so while they recommended chemotherapy, we declined and took Frodo home and gave him lots of love, and treats, and hoped for the best.

In regards to human bladder cancer, most cases fall into two general categories: (1) lower grade, superficial tumors, and (2) higher grade, invasive tumors.

There are three grades: Grade I tumors are easily identified and rarely metastasize; Grade II tumors have intermediate differentiation and extend deeper into the underlying tissues and about 20 percent will spread or metastasize; Grade III tumors are poorly differentiated and behave aggressively with an 80 percent or higher chance of metastasis.

Aias was referred to VRCC Oncology in April 2011 with a diagnosis of a high - grade mast cell tumor of the scrotum.

It has been observed that higher - grade tumors may be more likely to be ulcerated in appearance and cause local irritation.

High - grade tumors may be treated systemically with prednisone and / or chemotherapy drugs.

Tumors are graded on a scale of low, intermediate, and high.

Cells from the biopsy tissue are then examined under the microscope and the tumor is assessed as high grade (aggressive), intermediate, or low - grade (slow - growing).

Grade III (high - grade) tumors are the most invasive and aggressive and the most likely to spread to other parts of the body.

Those with the greatest risk for recurrence are those with large, high grade (II & III), or those with multiple tumors.