Sentences with phrase «high insulin concentration»

The U-formed shape of the dose - response curve for type 2 diabetic cultures and the parallel curves for high insulin concentration in control cultures indicate that the mechanism for the primary defect is different from the mechanism responsible for the induced reduction in acute insulin stimulation of GS.

This new environment will, like the in vivo environment or high insulin concentration in our experiment, influence cell metabolism in a new way, thereby diminishing previous metabolic influences.

Basal A0.5 values for diabetic cultures also seemed to increase, but there was no significant difference between low and high insulin concentrations (Fig. 4B).

Acute insulin stimulation increased glucose transport by 21 % in control cultures precultured at 1 pmol / l insulin, but at higher insulin concentrations we could not detect an effect of insulin on glucose uptake.

In accordance with other studies, we found an increased glucose uptake under acute insulin stimulation in cultures established from control subjects precultured under basal physiological insulin concentrations, but when precultured at a higher insulin concentration, we could not see an effect on acute insulin stimulation indicative of induced insulin resistance (10).

Acute insulin stimulation significantly increased the fractional activity FV0.1 of GS in control cultures in the range of 0.1 pmol / l to 0.1 nmol / l (P < 0.05) and in diabetic cultures in the range of 0.1 pmol / l to 1.0 nmol / l (P < 0.05), whereas higher insulin concentrations diminished the effect of acute insulin stimulation in a dose - dependent pattern.

Higher insulin concentrations (> 1 nmol / l) significantly reduced the ΔA0.5 in control as well as diabetic cultures (P < 0.05) in a parallel manner.

Higher insulin concentrations (> 1 nmol / l) significantly reduced the ΔFV0.1 in control as well as diabetic cultures (P < 0.05) in a parallel manner.

In contrast, type 2 diabetic cultures precultured at very high insulin concentrations expressed an increased basal glucose uptake and a reduced insulin stimulated uptake.

The decrease in NEFA concentration could have been due to hydrolysis of the ingested triacylglycerols by capillary bed lipoprotein lipase activity in response to the higher insulin concentrations (34).

For example, Dr. Tom Cowan (3) explained research that showed that heart attacks are not caused by a blockage in a coronary artery but by the deterioration of the small blood vessels in the heart from stress, smoking, high insulin concentrations, diabetes, and / or inflammation.

Cats fed the high - carbohydrate diet had significantly higher mean and peak (23 — 32 %) glucose concentrations and tended to have higher insulin concentrations than cats fed either the high - protein or the high - fat diet (54).

Not exact matches

High - protein, low - carbohydrate foods elicit lower glycemic responses compared with those containing high concentrations of carbohydrate, which can benefit dogs with insulin resistance or diabetes (57, High - protein, low - carbohydrate foods elicit lower glycemic responses compared with those containing high concentrations of carbohydrate, which can benefit dogs with insulin resistance or diabetes (57, high concentrations of carbohydrate, which can benefit dogs with insulin resistance or diabetes (57, 58).

At the end of the study, children who lived in neighborhoods with the highest concentrations of nitrogen dioxide and particulates had experienced greater declines in insulin sensitivity and had signs of impaired pancreatic beta cells, which produce insulin.

In the case of heart disease, Reaven says that high blood concentrations of insulin and glucose can damage the endothelium that lines coronary arteries and set the stage for the formation of plaques.

A higher concentration of indolepropionic acid also seemed to promote insulin secretion by pancreatic beta cells, which may explain the protective effect.

The study also identified several new lipid metabolites whose high concentrations were associated with improved insulin resistance and reduced risk of diabetes.

Acute insulin stimulation significantly decreases A0.5 for GS in cultures precultured at 0.1 pmol / l to 0.1 nmol / l and 10 — 100 nmol / l insulin, whereas higher chronic insulin concentrations diminished the effect of acute insulin stimulation (Fig. 4A).

Since we know the Gal4 - UAS system is sensitive to temperature and in fact, expression levels of these transgenes differ at 22 °C and 25 °C, Drosophila GBPs might also suppress ILP secretion from the insulin - producing cells when expressed at high concentrations.

Furthermore, homozygosity for null mutations at CYP2F1 was found associated with higher plasma interleukin - 8 concentrations; and at either A3GALT2 or NRG4, with markedly reduced plasma insulin C - peptide concentrations; hence identifying novel phenotypic associations at these genes.

«A High Fasting Plasma Insulin Concentration Predicts Type 2 Diabetes Independent of Insulin Resistance: Evidence for a Pathogenic Role of Relative Hyperinsulinemia,» Diabetes, 49 (12), 2094 - 2101.

The mean fasting serum insulin concentrations were 104 ± 18 pmol / L (17.3 ± 3.0 μU / mL) and 110 ± 21 pmol / L (18.4 ± 3.5 μU / mL) after the control and high - protein diets, respectively (Figure 4).

* Oddly enough, however, the experiments with fresh pancreatic islets and fat cells taken from the mice suggested that the positive effects of uncarboxylated osteocalcin on insulin only occurred at concentrations extremely low compared to those of undercarboxylated osteocalcin normally present in mice, while the effects on adiponectin and energy expenditure only occurred at normal to high concentrations.

Glycation is a factor of glucose concentration exposure and time, with more AGEs forming upon longer exposure to higher concentrations of glucose.33 It follows that in a body that is hyperinsulinemic, and a brain that is insulin - resistant, the peripheral hyperinsulinism will inhibit the clearance of soluble Aβ by IDE, thereby causing it to remain in the extracellular space for an extended amount of time, and the functional «hyperglycemia» in the brain will provide an elevated level of glucose — the perfect storm for glycation of Aβ and its aggregation into insoluble plaques.

High glucose and insulin concentrations in the bloodstream are not desirable because they promote fat storage and rebound hypoglycemia.

Patients with advanced AD show higher plasma but lower CSF insulin concentrations than healthy controls.40 Clearly, then, the lower concentration of insulin in the brain is not a result of reduced circulating levels in the blood.

The study found that ingestion of the very high molecular weight carbohydrate resulted in faster and greater increase in blood glucose and serum insulin concentration compared to the low molecular weight carb and the placebo.

In contrast, higher postprandial insulin concentrations and increased fat oxidation with breakfast skipping suggest the development of metabolic inflexibility in response to prolonged fasting that may in the long term lead to low - grade inflammation and impaired glucose homeostasis.

Eating a meal rich in animal protein, compared to one heavy in protein from plants, may also lead to higher concentrations in the blood of branched - chain amino acids, protein building blocks that have been linked to an inability to process insulin and an increased diabetes risk, the authors speculate.

Mean (± SE) insulin concentrations during the test period after the high - glycemic - index (HGI; •), low - glycemic - index (LGI; ▪), and HGI with lactulose (HGI - Lac; ▴) breakfasts.

Over time, high blood sugar and insulin concentrations promote desensitization of insulin receptors to insulin.

Insulin resistance is typically caused by sustained high blood sugar concentrations, which cause a continuous release of insulin by the pancreas to lower bloodInsulin resistance is typically caused by sustained high blood sugar concentrations, which cause a continuous release of insulin by the pancreas to lower bloodinsulin by the pancreas to lower blood sugar.

Disproportionately high plasma insulin concentration in hypertensive patients was first reported in the scientific literature more than fifty years ago.

You need to have a high plasma glucose concentration and spiked serum insulin levels to drive maximum cellular creatine delivery.

Higher protein content, lower concentrations of long chain polyunsaturated fatty acids, and presumably the lack of insulin - sensitizing hormones, as well as numerous other biologically active substances in infant formulas in comparison with breast milk, are thought to play a pathophysiological role in formula feeding associated decreased insulin sensitivity.

Diets high in protein or saturated fat do not affect insulin sensitivity or plasma concentrations of lipids and lipoproteins in overweight and obese adults.

Daily plasma glucose concentrations were 10 percent lower with the high - fiber diet than with the ADA diet (values for the area under the curve, 3743 ± 944 vs. 3365 ± 1003 mg ․ hour per deciliter [207.8 ± 52.4 vs. 186.8 ± 55.7 mmol ․ hour per liter]; P = 0.02), and plasma insulin concentrations were 12 percent lower (values for the area under the curve, 1107 ± 650 vs. 971 ± 491 μU ․ hour per milliliter [6642 ± 3900 vs. 5826 ± 2946 pmol ․ hour per liter]; P = 0.05)(Figure 1).

Glucose enters the brain across a concentration gradient, hyperglycemia in the blood leads to toxicity to neurons, so hyperglycemia is potentially toxic; high insulin is not if it is physiological.

Cedar berries have a high concentration of insulin and may be helpful in healing the pancreas.

The high - fiber diet also lowered the area under the curve for 24 - hour plasma glucose and insulin concentrations, which were measured every two hours, by 10 percent (P = 0.02) and 12 percent (P = 0.05), respectively.

Mean (± SE) 24 - Hour Profile of Plasma Glucose Concentrations (Panel A) and Insulin Concentrations (Panel B) during the Last Day of the American Diabetes Association (ADA) Diet and the Last Day of the High - Fiber Diet in 13 Patients with Type 2 Diabetes Mellitus.

Lactate, which increases during starvation, can induce hepatic ketogenesis.2 Low - carbohydrate, fat - rich meals can enhance alpha - cell secretion of glucagon and lower insulin concentrations.3, 4 Plasma fatty acid concentrations can be twice as high during low - carbohydrate diets as compared with the usual carbohydrate intake in the postabsorptive period.5 Increased concentrations of free fatty acids in the absence of carbohydrate - induced inhibition of beta - oxidation of fatty acids and in the presence of an abnormally high ratio of glucagon to insulin and elevated concentrations of lactate may have caused ketoacidosis in our patient, who was trying to avoid all dietary carbohydrates.

Moreover, it should be noted that ketogenic diets are only relatively high in protein18, 106 and that some recent studies have demonstrated that VLCKD can even cause a regression of diabetic nephropathy in mice.109 With regard to possible acidosis during VLCKD, as the concentration of KBs never rises above 8 mmol / l10 this risk is virtually inexistent in subjects with normal insulin function.

Fructose maintains a low glycemic index of 23 and a low glycemic load, but paradoxically it is routinely used to induce insulin resistance in laboratory rodents at high (35 — 65 % of energy) dietary concentrations (85,86).

Nevertheless, it is established that repeated consumption of high glycemic index, mixed meals results in higher mean 24 h blood glucose and insulin concentrations when compared with low glycemic index, mixed meals of identical caloric content (75,76).

If the blood glucose concentration is consistently higher than normal, it may indicate that your dog's pancreas is not secreting (enough) insulin.

This disorder, which is the result of a relative or absolute insulin deficiency or of peripheral cell insensitivity to insulin, is characterized by high blood glucose concentrations such that the renal threshold is exceeded.

Diets high in protein are associated with lower postprandial glucose and insulin concentrations than diets high in either fat or carbohydrate in normal cats

In Type I diabetes, glucose concentrations are high because of a decrease in the production of insulin.