But cardiomyocytes that had been mixed with
high levels of glucose matured late or failed to mature altogether, and instead generated more immature cells.
Not exact matches
When developing heart cells are exposed to
high levels of glucose, the researchers found, the cells generate more building blocks
of DNA than usual, which leads the cells to continue reproducing rather than
mature.
Researchers at the Eli and Edythe Broad Center
of Regenerative Medicine and Stem Cell Research at UCLA have discovered how
high glucose levels — whether caused by diabetes or other factors — keep heart cells from
maturing normally.