Sentences with phrase «high microsatellite instability»

The FDA granted accelerated approval to pembrolizumab (Keytruda, Merck) as a second - line treatment for all metastatic solid tumor types classified as MSI - hi (high microsatellite instability) or dMMR (deficient DNA mismatch repair).

The FDA approved nivolumab (Opdivo), an anti-PD-1 checkpoint inhibitor, for patients 12 years and older with relapsed colorectal cancer that is characterized by high microsatellite instability (MSI - hi).

In fact, the Food and Drug Administration's approval of pembrolizumab in May 2017 for adult and pediatric patients with solid tumors and high microsatellite instability, was the first time it had approved a cancer treatment based on a genetic feature rather than the cancer's location of origin.

But a caveat is that many patients have few if any T - cells in their tumors, which means the treatment is effective in only about 20 percent of patients who also have high microsatellite instability.

Not exact matches

In 2017, the U.S. Food and Drug Administration (FDA) approved the cancer drug Keytruda (pembrolizumab) for a range of solid tumors that are either microsatellite instability - high (MSI - H) or mismatch repair deficient (dMMR).

Both cancer types demonstrate a high frequency of microsatellite instability, where the repair mechanism for DNA is broken, and mutations in POLE, a gene responsible for producing a protein involved in DNA replication and repair.