Sentences with phrase «high mutation»

These genomic changes led to high mutation rates in both tumor types.

However, we do encounter negative and positive selection, in addition to genetic drift, at the level of the mutation, usually at high mutation loads.

«Short generation times and high mutation rates associated with short lifespan and fast growth enable new species to appear at a faster rate in the tropics,» he says.

However, the enzyme isn't something that acts once — it is chronically elevated along with HPV infection, leading to years or decades of higher mutation rates.

HUR K Junho, first author of the study said, «The data showed that Cpf1 RNP's delivery to mouse embryos resulted in knocking out the intended genetic functions with high mutation frequencies, 64 % and 33 % respectively.

The researchers also found high mutation rates of YME1L1 in other cancers.

The investigators systematically ruled out mundane explanations, such as cross-pollination of a mutant plant by a normal one, an extremely high mutation rate or the presence of another, hidden copy of hothead.

The variation suggests that in some species, genes that cause high mutation rates — for instance, by interfering with DNA repair — go unchecked.

The mtDNA has a much higher mutation rate than nuclear DNA, which by itself might imperil species survival, because most DNA mutations are deleterious.

We designed six Cas9 / gRNAs targeting four different genes, and all these Cas9 / gRNAs showed high mutation efficiency in goat primary fibroblasts (Figure 1).

Our analyses reveal an accumulation of 13 mutations per genome per year that results in a 2 -3-fold higher mutation load in active genes and promoters in aged SCs.

High mutation burden correlates with defective SC function.

Yet despite all the fanfare about them, these drugs rarely cure anyone, because cancer cells» high mutation rate allows them to dodge the pathway concerned.

The high mutation rate led to fears at the time that if the virus rapidly altered, it could also quickly become more virulent.

This may help explain the high mutation rate that allows the virus to escape from immune responses, says Mr. Law.

RNA viruses pose a significant public health problem worldwide because their high mutation rate allows them to escape the immune response.

The high mutation rate in mtDNA plus ovarian selection thus provide a powerful tool for humans (and animals) to adapt to an environmental change, without endangering a population's overall survival.

This rapid, malignant metastatic formation of melanoma, was previously put down to the high mutation rate that is characteristic of melanoma, i.e. genetic changes that stimulate the growth of cancer cells.

«Rats have a higher mutation rate [than humans], so you get these different [families] developing in Polynesia,» he says.

What we did not know was that BCC is also the cancer with the highest mutation rates.

CLL was an appealing model for this study because its high mutation rate in the short stretch of DNA that encodes the IG heavy chain (IGH).

The hypermutated microsatellite instability group exhibited a high mutation rate, as well as few copy number alterations, but did not carry mutations in the POLE gene.

«Cancer cells by definition have high mutation rates and genomic instability even at the very earliest stages, so you could imagine building a virus that could destroy even the earliest lesions and be used as a prophylactic,» says O'Shea.

Although clinical trials have collectively shown a disease control rate of approximately 45 percent using this approach in ovarian cancer, they have yet to establish selective benefit in BRCA1 / 2 - deficient cancers, which should generate stronger anti-tumor immune responses given their higher mutation rate.

Yet, this is unlikely to succeed because of the high mutation rate of this virus.