Sentences with phrase «high mutation rates in»

CLL was an appealing model for this study because its high mutation rate in the short stretch of DNA that encodes the IG heavy chain (IGH).

Not exact matches

@ED The only thing that is assumed to be at least more or less constant in evolutionary theory is the mutation rate of individual genes, and even that, since mutations are known, eg, to increase under higher radiation, is only true «on average, over the long run».

«The type of inflammation seen in psoriasis is known to promote insulin resistance, and psoriasis and diabetes share similar genetic mutations suggesting a biological basis for the connection between the two conditions we found in our study,» said the study's senior author Joel M. Gelfand, MD MSCE, a professor of Dermatology and Epidemiology at Penn. «We know psoriasis is linked to higher rates of diabetes, but this is the first study to specifically examine how the severity of the disease affects a patient's risk.»

«Short generation times and high mutation rates associated with short lifespan and fast growth enable new species to appear at a faster rate in the tropics,» he says.

ETH researchers have now shown that the high estimated mutation rates at the start of the epidemic were due to the limited number of virus samples at the time in combination with the computer models used, which calculate the estimates using genetic data from virus samples and from underlying assumptions.

To find BRCA mutations — which are very rare — most studies have examined families with very high rates of breast and other cancer in young family members.

The study, which compared each model's success in Caucasian women with those of Asian descent (Chinese, Japanese, Filipino, Korean and Vietnamese), also raised important questions about the effect of race on cancer development: When Caucasian and Asian patients with similar family histories of breast and ovarian cancer were compared, the Asian women had higher rates of genetic mutation, although the rates of these cancers for Asians have traditionally been lower.

Moreover, higher filaggrin mutation rates, which result in a loss of urocanic acid, correlated with higher vitamin D levels in the blood.

Now scientists have uncovered what may be a secret of that versatility, at least for certain microbes: individuals with a high rate of genetic mutation, says a Report in today's issue of Science.

Melott said the uptick in radiation from muons would have been high enough to boost the mutation rate and frequency of cancer, «but not enormously.

Because older sperm tend to have more chromosomal mutations — ranging in seriousness from harmless to lethal — there is among older fathers a higher rate of kids born with certain rare tumors, neural - tube defects, congenital cataracts, and upper limb defects.

Sebat and colleagues discovered that spontaneous structural mutations occurred at a surprisingly high rate in individuals — 20 percent — and mutations in autism tended to disrupt genes.

In newborns exposed to secondhand smoke, mutations in an important gene occur at a high rate, according to a pilot study in next month's Nature MedicinIn newborns exposed to secondhand smoke, mutations in an important gene occur at a high rate, according to a pilot study in next month's Nature Medicinin an important gene occur at a high rate, according to a pilot study in next month's Nature Medicinin next month's Nature Medicine.

The response rate was much higher in patients whose tumours carried mutations to genes involved in repairing DNA.

A region inside the csd gene in particular represents a hot - spot with a high evolutionary rate that, together with certain amino acid mutations, decisively contributes to the formation of new csd alleles in the flanking regions.

More importantly, the plants passed this elevated mutation rate onto their offspringat a rate two to four times higher than in the progeny of unstressed parents — even when these offspring were not challenged with UV or pathogens.

«Rats have a higher mutation rate [than humans], so you get these different [families] developing in Polynesia,» he says.

Researchers found that tumors carrying mutations in the AR and FOXA1 pathways had a significantly higher response rate, 94.1 % compared to 16.6 % in tumors without the mutations.

Notably, the de novo mutation rates in this study were higher in exonic regions regardless of the paternal age.

The observed mutation rate in coding regions seems to reflect the aggressiveness of breast cancer subtypes: lower in luminal A (0.84 mutations / Mbp) than luminal B (1.36 mutations / Mbp), higher in Her2 - enriched (2.05 mutations / Mbp) and Basal - like (1.68).

FLT3 mutations are more common in patients with normal karyotype and appear to be associated with a higher rate of relapse after conventional chemotherapy.

Mutation rates ten-fold higher than typical lung cancers in humans, though within three-fold of «hypermutator» tumors with mutations in DNA repair genes.

Recent studies, however, have suggested that allelic recombination influences the underlying mutation rate, as high mutation rates are inferred in regions of high recombination.

That's why it's possible to have a very high validation rate (> 90 %) for somatic mutations in solid tumors like lung cancer.

Although clinical trials have collectively shown a disease control rate of approximately 45 percent using this approach in ovarian cancer, they have yet to establish selective benefit in BRCA1 / 2 - deficient cancers, which should generate stronger anti-tumor immune responses given their higher mutation rate.

Using exome sequences from 3222 British - Pakistani individuals with high parental relatedness, we estimate a mutation rate of 1.45 ± 0.05 × 10 -LRB--8) per base pair per generation in autosomal coding sequence, with a corresponding non-crossover gene conversion rate of 8.75 ± 0.05 × 10 -LRB--6) per base pair per generation.

Given that most amino acid changes are slightly deleterious [12] and assuming that most genes in the genome are relatively conserved, one would expect that regions of the genome with a low recombination rate, when compared to those with a high rate, would show i) a higher ratio of non-synonymous (amino acid replacing) to synonymous (silent) substitutions (ω) and ii) a higher degree of protein divergence (dA) due, in both cases, to the reduced effectiveness of selection against slightly deleterious mutations.

Functional genomic elements, for example, are expected to be found at higher density in genome regions with a high recombination rate where fewer slightly deleterious mutations accumulate than in areas of low recombination [13].

So the 26 % carrier rate does not reflect the chance of any golden retriever carrying the mutation and the 1 % Affected rate we've observed is very likely higher than what would be expected in the general population of Goldens.

A KCNQ1 V205M missense mutation causes a high rate of long QT syndrome in a First Nations community of northern British Columbia: A community - based approach to understanding the impact.