Findings: mean sodium excretion was 4.93 g. Compared to a reference range of 4.00 - 5.99 g a day, the odds ratio for death and cardiovascular events was 1.15 for
high sodium excretion (over 7 g a day) but was even greater at 1.27 for a low sodium excretion (below 3 g).
«Further, the study also showed that consuming larger amounts of potassium in the diet counterbalances the adverse affect of
high sodium excretion on blood pressure in cardiovascular disease outcomes.»
Not exact matches
But approximately 90 percent of the participants in the PURE study had either a
high (greater than 5.99 grams per day) or moderate (3 to 5.99 grams per day) level of
sodium excretion; approximately 10 percent excreted less than 3 grams per day, and only 4 percent had
sodium excretion in the range associated with current U.S. guidelines for
sodium intake (2.3 or 1.5 grams per day).
The levels of hormones associated with water and
sodium excretion had numerous differences after the sleep - deprivation, and blood pressure and heart rate were significantly
higher.
Danish researchers have found that sleep deprivation causes healthy children, between the ages of eight and twelve, to urinate significantly more frequently, excrete more
sodium in their urine, have altered regulation of the hormones important for
excretion, and have
higher blood pressure and heart rates.
First, one 24 - hour urine collection might be insufficient to characterize an individual's habitual salt intake, but it does accurately reflect the average salt consumption of groups of subjects.42 Thus, our analyses based on tertiles of 24 - hour urinary
sodium should be less vulnerable to the
high intraindividual variability of
sodium excretion.
Another 2011 study confirmed this observation; not only was lower
sodium excretion associated with
higher CVD mortality, but baseline
sodium excretion did not predict the incidence of hypertension, and any associations between systolic pressure and
sodium excretion did not translate into less morbidity or improved survival.
Urinary
sodium excretion was associated with all - cause mortality, such that those with the
highest urinary
sodium excretion, as well as the lowest
excretion, had reduced survival.
From Table 1 it can be seen that both BMI and the percentage of male subjects increased with increasing
sodium excretion, and that the percentage of subjects who had CVD events increased from the second
highest category of
sodium excretion to the
highest.
In the lowest category of
sodium excretion, with an average of 1.9 grams per day, the percentage of subjects that had CVD events was
higher (7.2 percent) than that of the second category (6.8 percent), with average
excretion of 3 grams per day, even though the average BMI and percentage of
high - risk males was lower in the lowest category.
The percentage of CKD patients who had cardiovascular events during follow - up was
higher (18.4 percent) in the lowest quartile of urinary
sodium excretion (average
excretion 2.5 grams per day) than the 16.5 percent in the second quartile (average
excretion 3.3 grams per day).
but only in the
highest quartile of
sodium excretion.
The authors concluded that «among patients with CKD,
higher urinary
sodium excretion was associated with increased CVD risk,» a conclusion that is greatly exaggerated.
It is noted that a
sodium intake of less than 2 grams per day, which approximates the
sodium intake of the paleo diet with no added salt, was associated with a 68 percent increase in cardiovascular disease risk during follow - up of fifty - four months in the study reviewed in the Kresser blog.26 Another study, which excluded subjects with cardiovascular disease, hypertension and diabetes, found that after thirty - three months, the cardiovascular risk of those with daily
sodium excretion of 1.9 grams was 36 percent
higher after adjustment for body mass index and sex than the risk of those excreting 3 grams.6
The
sodium excretion of the study subjects of 3.8 grams per day was significantly
higher than the average
sodium excretion of around 3.4 grams per day in the U.S. and Canada.
Urinary
sodium excretion was inversely associated with cumulative incidence of ESRD such that those with the lowest
sodium excretion had the
highest incidence of ESRD.
These values are derived from twenty - four - hour urinary
sodium excretion measurements in studies involving over one hundred thousand participants.4 Cordain implies that
sodium intake in «non-westernized people» is far lower than in the US, but in fact the average daily
sodium intake in Asia, Africa and the Middle East is about 50 percent
higher than the 3.4 grams per day in the U.S. and Canada.24, 25
«Both
higher and lower levels of estimated
sodium excretion were associated with increased risk,» the O'Donnell team concluded.
In the process,
sodium is lost too, and it may result in lowered blood pressure (in Overlack et al. the counter-regulators had 10 %
higher average
sodium excretion than salt - resistant group, and 20 %
higher than salt - sensitive group).
Excess
sodium excretion of greater than 7,000 milligrams and a deficiency of less than 3,000 milligrams per day were both associated with a
higher risk of stroke, heart attack, and death.
Sellmeyer DE, Schloetter M, Sebastian A. Potassium citrate prevents increased urine calcium
excretion and bone resorption induced by a
high sodium chloride diet.
After birth, their kidneys have not fully developed the ability to conserve water by producing more concentrated urine or increase the
excretion of salt to keep blood
sodium levels from rising too
high.