Sentences with phrase «high specificity of»

In addition, sema1a levels were unaffected, demonstrating the high specificity of RNAi (not shown).

According to our current analysis, prostate volume did not affect the eNose results, potentially indicating high specificity of our sensor array to cancer.

The other related genes, DFR - A and DFR - C, were examined and no mutations were found, confirming the high specificity of the CRISPR / Cas9 system.

Not exact matches

If you're building links for a variety of sites in a variety of niches, establish a group of higher level tags (i.e. Health, Travel, Home & Garden, etc.), and use a second or even third level of specificity, if needed.

Some events do not yield to a high degree of symbolic specificity.

Like connoisseurs of craft beer, fine wine, and «medicinal» marijuana, pepper people talk shop with a geeky enthusiasm and specificity: There are flavor profiles, experimental strains, and body highs like the one I'm getting from that furious little Reaper.

Having that in mind, they were probably developed carefully based on the specificities of the socium and the current mentality such that to resonate most with the masses, to remove polarizations, homogenise, purify (in the case of Nazism) 1, morally rejuvenate, unite the nations and direct them towards a common «higher» goal.

«Our SUVmax cutoff can be used to confirm or rule out prostate cancer with a very high degree of sensitivity and specificity.»

Prasad notes, «This validated cutoff of 3.15 for SUVmax enables the diagnosis of prostate cancer with a high sensitivity and specificity in both unifocal and multifocal disease.»

When the researchers looked at a combination of three proteins in patients with concussion — copeptin, galectin 3, and matrix metalloproteinase 9 — they found significant changes in the levels that provided a high degree of sensitivity and specificity for injury compared to the controls.

Given that the newly discovered protein FGB1 has such a high affinity and specificity to beta -1,6-glucans from fungi cell walls, it is possibly suitable for the diagnosis of human infections.

A cell may receive a genetic signal to build a lipid for a certain cellular purpose, but the exact type may not be indicated with a high degree of specificity.

«I was surprised by the specificity of the results, that the emotional memory improvement was specifically for the negative and high - arousal memories, and the ramifications of these results for people with anxiety disorders and PTSD,» Mednick said.

The combination of high crosslinking yields, excellent specificity, and elimination of photodamage to other chromophores represents an important advance toward the precise identification of contacts in nucleoprotein complexes.

«The fast growth, high efficiency and specificity of enzymes employed in the anaerobic litter deconstruction carried out by these tropical soil bacteria make them useful templates for improving biofuel production.»

This approach makes it possible to not only classify cells, but also to digitally sort them with a high level of specificity.

This small molecule is in clinical trials against cancer and has high specificity and good pharmacological properties, which could warrant its further development as antiviral drug for treatment of pH1N1 virus infection,» Dr. Oxana Denisova says.

Prof. You - Me Kim and her student Dajung Jung at Pohang University of Science and Technology (POSTECH), in collaboration with Prof. Wonhwa Cho's group at the University of Illinois at Chicago, have identified that the majority of human Src homology 2 (SH2) domains not only bind to proteins, but also interact with membrane lipids with high affinity and specificity.

At ABclonal, we have nearly 100 existing chromatin immunoprecipitation (ChIP)- validated antibodies with a higher specificity than most commercial antibodies, which are used for a wide range of epigenetics studies, from those investigating developmental processes to those researching various diseases.

But between the extremes of small, but imprecise, molecules and floppy, but high - specificity proteins, there exists a middle ground — peptides.

«Our study reveals important differences and specificities in the mechanism of action of high - and low - dose aspirin in metastatic and nonmetastatic cancer cells with different tumor origins and suggests that the ability of aspirin to prevent platelet - induced c - MYC [an oncoprotein] expression might be selective for a nonmetastatic phenotype.»

«The whole world has been in urgent need of a serological method to distinguish dengue virus from Zika virus infections, and this the first to have such high sensitivity and specificity in dengue - endemic regions,» said Eva Harris, study co-author and UC Berkeley professor in the Division of Infectious Diseases and Vaccinology at the School of Public Health.

The unique platform, which is referred as a «4D microscope,» combines the sensitivity and high time - resolution of phase imaging with the specificity and high spatial resolution of fluorescence microscopy.

By fencing off the reactive centre of B12 with lots of groups, the molecule keeps its high reactivity and specificity.

«The fact that their machine - learning approach has such high specificity and sensitivity and is useful at the level of an individual child is truly impressive,» says Charles Nelson, professor of pediatrics and neuroscience at Harvard University, who was not involved in the study.

The enzyme, isolated from Thermus aquaticus, greatly simplifies the procedure and, by enabling the amplification reaction to be performed at higher temperatures, significantly improves the specificity, yield, sensitivity, and length of products that can be amplified.

There is no question that the great specificity of any one conscious perceptual experience — such as the throbbing pain of the socket following extraction of the lower right wisdom tooth, the feeling of familiarity in dj vu, the aha experience of sudden understanding, the azure blue of a high mountain vista, the despair at reading about one more suicide bombing — is mediated by coalitions of synchronized cortical nerve cells and their associated targets in the satellites of the cortex, thalamus, amygdala, claustrum and basal ganglia.

«In - Dx has high sensitivity and specificity for detection of the most common infectious organisms which will help physicians quickly rule in or rule out specific offending bacteria,» Etchebarne said.

Further evidence of the high specificity that this method of stimulation can bring to human brain modulation has been provided by intraoperative investigations (Histed et al., 2013; Logothetis et al., 2010).

The high expression specificity of SHOT - RNAs implies their potential use as a novel biomarker, and the next steps, says Dr. Kirino, are to explore relationships between SHOT - RNA expression and prognostic factors.

By providing researchers with a way to accurately map the genomic landscape of CRISPR — Cas9 activity, we can reduce the occurrence of off - target effects by selecting for targets with the highest possible activity and specificity,» said Dr. Rachel Haurwitz, President and CEO of Caribou.

The research ideas you develop at the workshop should: • Lead to the significant advancement of our understanding of sensor technologies suitable for liquid biopsy • Consider the practical challenges of low volume liquid usually taken for analysis and the inconsistency of sample preparation across point of care sites • Prioritise biomarkers with high specificity for cancer or even for multiple cancer types, including markers specific to cancers that will become aggressive as opposed to non-lethal disease

In part due to lack of a common and transparent validation framework, antibodies often turn out to have high variability and low specificity.

These use a high - throughput screening approach combined with MALDI - IMS to assess the specificity of those drugs on a transgenic mouse model of AD.

Finally, we analyzed the tissue specificity of Acks induction under a high temperature.

Genetically engineered mice now act as robust engines for the generation of diverse repertoires of affinity - matured, fully - human variable regions with intrinsic drug - like properties necessary for successful development including high potency, specificity, manufacturability, solubility and low risk of immunogenicity.

The resulting platform provides specificity, sensitivity, and speed for analyzing complex samples by covering smaller amounts of sample more comprehensively with higher measurement throughput.

Karpinski J, Hauber I, Chemnitz J, Schäfer C, Paszkowski - Rogacz M, Chakraborty D, Beschorner N, Hofmann - Sieber H, Lange UC, Grundhoff A, Hackmann K, Schrock E, Abi - Ghanem J, Pisabarro MT, Surendranath V, Schambach A, Lindner C, van Lunzen J, Hauber J, Buchholz F. Directed evolution of a recombinase that excises the provirus of most HIV - 1 primary isolates with high specificity.

The Clinical Biomarkers Facility offers services for high - throughput and highly specific analyses of protein biomarker candidates in body fluids such as plasma, serum, cerebrospinal fluids etc. and cell and tissue lysates using molecular tools such as proximity extension and proximity ligation technologies (PEA and PLA) providing assays with high specificity and sensitivity in complex biological matrices.

In bacteria the computationally re-designed receptors show a high degree of specificity, with related ligands showing 2 — 3 fold less affinity [5].

Due to the serious side effects caused by the activation of the pharmacologically and structurally closely related subtypes, it is essential that 5 - HT2C agonists developed for clinical use have a high specificity and subtype selectivity.

The assay was shown to detect 37 ZIKV isolates covering a wide geographic in Africa and Asia over 36 years but none of the 31 other flaviviruses tested showing high analytical specificity.

We continue to identify the biological pathways of greatest interest to our consumers and continuously strive to provide products of the highest quality with increased specificity, reproducibility and sensitivity.

Peptides can target the ephrin - binding pocket of Eph receptors with high affinity and specificity, affecting receptor function.

Iterative cycles of hypermutation and selection continue until antibodies of high antigen binding specificity emerge (affinity maturation).

In that case, the color of the ink and light can be tuned across a fairly wide spectrum, allowing for shape changes with high specificity.

It is important to distinguish lineage specific gene expression shown here, which occurs at a high level and with a degree of specificity in the different population compartments, to the low level of genome wide transcription observed in ES cells by others [22], or with transcript initiation at many loci noted previously in ES cells [23].

Overall, we suggest a preference for HiSeq2000 and Complete Genomics in cancer genome studies where sensitivity for detection of low frequency variants matters most, whereas the two Life Technologies platforms might be better suited when calling SNVs with high specificity.

Conclusions: We validated (68) Ga - DOTATATE PET as a novel marker of atherosclerotic inflammation and confirmed that (68) Ga - DOTATATE offers superior coronary imaging, excellent macrophage specificity, and better power to discriminate high - risk versus low - risk coronary lesions than -LSB-(18) F] FDG.

Using sazetidine - A as a template, medicinal chemists developed multiple series of novel ligands with modifications to the pyridine core, azetidine ring, and alkynyl side chain with the objective of designing α4β2 - nAChR partial agonists of high specificity.