Theoretically, a sustained increase could stabilize or even lengthen telomeres over time, as shown in a previous study where intensive lifestyle intervention led to
higher telomerase activity after 4 months, and longer telomeres after 5 years, with such changes associated with better adherence.43, 44
Researchers at the University of California were the first to show that meditators have significantly
higher telomerase activity than non-meditators.
Not exact matches
His research focuses on the development of
high - precision, single - molecule methods to study the mechanism of action of macromolecular machines, such as dynein,
telomerase, and Cas9.
An inherently
high stalling frequency of the S. cerevisiae
telomerase may account for its in vitro properties and for the irregular telomeric sequences of this yeast.
Telomerase reverse transcriptase promoter mutations can cause high - level reactivation of the telomerase enzyme in bladd
Telomerase reverse transcriptase promoter mutations can cause
high - level reactivation of the
telomerase enzyme in bladd
telomerase enzyme in bladder cancer.
Lin found that, in mice, about 3 - 5 percent of all liver cells express unusually
high levels of
telomerase.
Conversely, mutations that kick
telomerase into
high gear are frequently found in liver cancers.
Telomere length predicts both cellular health and disease in rodent models and humans.8 Shorter telomeres predict onset of cardiometabolic diseases of aging.9 Chronic stress is associated with
higher inflammation, shorter telomeres, and lower activity levels of
telomerase, the cellular enzyme that elongates telomeric DNA.10, 11 Levels of amyloid beta (Aβ) proteins circulating in the blood appear to be stress - related in rodent models12 and may be affected by stress reduction, and greater Aβ42 / Aβ40 ratios are associated with lower risk of dementia.13
At the Shamatha Project, a three - month intensive meditation retreat, Blackburn and UC Davis researchers found
telomerase activity in participants» white blood cells was one - third
higher than in a control group's.
Of the two
telomerase components analyzed, Tert (
telomerase reverse transcriptase) expression did not show any differences between groups, but Terc (
telomerase RNA component) transcription was significantly
higher in the IVC testes (Fig. 2B).
In recent years, several reports (1 - 10) have emerged claiming to have uncovered such functions, but generally in vitro and in nearly all cases under unphysiologically
high and / or persistent forced expression of the
telomerase gene.