Sentences with phrase «high viral load in»

Once the drug effect is over, the replication process retains its frequency thereby leading to high viral load in the body.

The first days after HIV infection are very important because sexual partners are exposed to extremely high risks of infection due to the subsequent high viral load in the infected person.

Deadly contaminated sparrows showed high viral loads in all organs (Figure 2), while in the surviving ones, the viral loads were much lower and detected only in some of the organs tested: approximately 104.55 RNA copies per mL for swabs» specimens, 105.09 RNA copies per gram for feathers, and 104.72 RNA copies per gram for organs.

Not exact matches

Hepatitis B viral load testing is typically done in the third trimester of pregnancy, so that maternal antiviral therapy can be started if is very high, helping identifying mothers who are highly viremic.

In addition, the investigators found, among the HPTN 052 participants who failed treatment, those who had a higher viral load when they joined the study were more likely to develop resistance to their antiretroviral drugs.

In addition, the investigators found that among the HPTN 052 participants who started antiretroviral therapy early but failed treatment before May 2011, those who had a higher viral load when they joined the study were likely to develop resistance to their antiretroviral drugs.

Patients who had a higher Ebola viral load when diagnosed with the diseases had a higher rate of eye inflammation and new vision problems, said Dr. Mishra, who spent five months working as a World Health Organization clinical consultant for the Ebola response in Sierra Leone.

Higher bacterial load in semen could lead to higher IL - 1b levels, which in turn could induce viral shedding, thereby increasing viral load.&Higher bacterial load in semen could lead to higher IL - 1b levels, which in turn could induce viral shedding, thereby increasing viral load.&higher IL - 1b levels, which in turn could induce viral shedding, thereby increasing viral load.»

With HIV, for example, the risk of passing the disease between partners increases with higher viral load: For every 10-fold increase in viral concentration, one 2012 study suggests there is about a threefold increase in the risk of transmission per sexual act.

Patients can remain in this stage for decades with high viral load but no apparent damage to the liver.2 There are two treatment options for HBV immune tolerant patients: pegylated interferon strategy, or nucleos (t) ide analogues.3

This can lead to substantially higher early viral loads, which in turn can increase the chance of the infection spreading to the brain and worsen clinical outcome.

The sooty mangabey, found in West Africa, has somehow adapted to the simian immunodeficiency virus — the nonhuman version of HIV — so that even with a high viral load, it rarely gets sick.

In non-survivors, viral load is 100-fold higher than that of survivors throughout infection and does not decline after peak.

The first couple days of symptoms are usually when you're most infectious because that's before your immune system has begun to quell the infection, and so the viral loads in your infected bodily secretions (e.g., mucus and saliva) are the highest.

In contrast for ranavirus, a highly virulent pathogen capable of decimating amphibian populations, populations living close to agriculture with high baseline tolerance had higher viral loads than populations far from agriculture with inducible tolerance.

The team of researchers harvested hematopoietic stem cells from three macaques prior to SHIV infection of all six animals in the study, treated the animals with anti-retroviral therapy (ART) to reduce viral load and mimic the situation in human HIV - infected patients who are treated with ART, and then exposed the three monkeys from which they had collected hematopoietic stem cells to a high dose of radiation.

Viral loads determined in samples collected post-mortem from those chickens were high, with an average of 107.27 RNA copies per mL for swabs» specimens, 108.04 RNA copies per gram for feathers, and 1010.16 RNA copies per gram for organs (Figure 2).

We have very strong reason to believe that transmission occurs when the viral load in bodily fluids is high, on the order of millions of virions per microliter.

Professional Duties & Responsibilities Biomedical and biotechnology engineer with background in design of biomaterials, biosensors, drug delivery devices, microfrabrication, and tissue engineering Working knowledge of direct cell writing and rapid prototyping Experience fabricating nanocomposite hydrogel scaffolds Proficient in material analysis, mechanical, biochemical, and morphological testing of synthetic and biological materials Extensive experience in bio-imaging processes and procedures Specialized in mammalian, microbial, and viral cell culture Working knowledge of lab techniques and instruments including electrophoresis, chromatography, microscopy, spectroscopy, PCR, Flow cytometery, protein assay, DNA isolation techniques, polymer synthesis and characterization, and synthetic fiber production Developed strong knowledge of FDA, GLP, GMP, GCP, and GDP regulatory requirements Created biocompatible photocurable hydrogels for cell immobilization Formulated cell friendly prepolymer formulation Performed surface modification of nano - particle fillers to enhance their biocompatibility Evaluated cell and biomaterial interaction, cell growth, and proliferation Designed bench - top experiments and protocols to simulate in vivo situations Designed hydrogel based microfluidic prototypes for cell entrapment and cell culture utilizing computer - aided robotic dispenser Determined various mechanical, morphological, and transport properties of photocured hydrogels using Instron, FTIR, EDX, X-ray diffraction, DSC, TGA, and DMA Assessed biocompatibility of hydrogels and physiology of entrapped cells Evaluated intracellular and extracellular reactions of entrapped cells on spatial and temporal scales using optical, confocal, fluorescence, atomic force, and scanning electron microscopies Designed various biochemical assays Developed thermosensitive PET membranes for transdermal drug delivery application using Gamma radiation induced graft co-polymerization of N - isopropyl acylamide and Acrylic acid Characterized grafted co-polymer using various polymer characterization techniques Manipulated lower critical solution temperature of grafted thermosensitive co-polymer Loaded antibiotic on grafted co-polymer and determined drug release profile with temperature Determined biomechanical and biochemical properties of biological gels isolated from marine organisms Analyzed morphological and mechanical properties of metal coated yarns using SEM and Instron Performed analytical work on pharmaceutical formulations using gas and high performance liquid chromatography Performed market research and analysis for medical textile company Developed and implement comprehensive marketing and sales campaign