Sentences with phrase «higher doses increases»

«Research shows that a high dose increases the number of satisfying sexual encounters by just one a month, and it does have side effects,» Dr. Wierman says.

Higher doses increase the force of muscle contractions, possibly by stimulating more calcium release from the sarcoplasmic reticulum of muscle cells.

They provided them with doses of either 100, 200 or 400 mg of caffeine and analysed metabolic rate - what they found was that results were dose dependent, with the highest dose increasing plasma glycerol levels.

Higher doses increased the effect, with 55 per cent of males in the 0.3 ppm group affected.

Not exact matches

Coffee consumption was also consistently associated with significantly lower risk of gallstone disease.25 A non-linear dose response was also apparent, though risk sequentially reduced as consumption increased from two to six cups a day.25 High versus low consumption was associated with a marginally higher risk of gastro - oesophageal reflux disease, but this did not reach significance.64

Research has shown that ECGC in high doses may help increase calorie burn and alter levels of «hunger hormones,» helping to reduce appetite.

Taking supplements during lactation rapidly increases the concentrations of thiamin, riboflavin, and vitamin B - 6 in milk, but increases in vitamin B - 12 levels are small even when high doses are given to the mother for 2 months.

Another secondary analysis examining the association between the maximum oxytocin dose and the risk of uterine rupture (103) noted a dose — response effect between increasing risk of uterine rupture and higher maximum doses of oxytocin.

Researchers at St. Michael's Hospital and the Institute for Clinical Evaluative Sciences (ICES) found that rates of high - dose opioid dispensing across Canada increased from 781 units per 1,000 people in 2006 to 961 units per 1,000 people in 2011.

This dose would now be considered a low dose, but the authors note that randomised trials of higher doses have not found that statins cause an increase in muscle related symptoms, other than the very small increase in myopathy.

Additionally, I predict that at the completion of our study, despite the higher doses given per treatment in the experimental accelerated, hypofractionated RT arm, there will be no increased toxicity with this regimen.

Intermittent lower - dose exposures can be as toxic as a single higher - dose exposure; Miller cites monkey research showing that either 10 nontoxic weekly doses or one toxic dose of an organophosphate pesticide led to the same increase in brain wave activity as measured by electroencephalogram, or EEG.

«In an earlier phase I clinical study, our group has shown that increasing the dose of radiation delivered daily with high precision and using image guidance may offset the need for chemotherapy in improving survival, and it may also improve quality of life measures by reducing treatment periods in half.

We worked with colleagues from Imperial College London, who used our results in a mathematical model, which predicts that the addition of high dose ivermectin increases the impact on malaria reduction by potentially as much as 61 %.»

The researchers confirmed these findings in a mammary carcinoma mouse model — treatment with dasatinib just a few days after administering two high doses of chemotherapy prevented tumor growth and increased survival rates.

In this case, a higher dose could actually increase sensitivity to pain.

At a 0.2 - millimolar sucralose dose similar to the concentration found in the blood of people with high consumption of low - calorie sweeteners — equal to four cans of diet soda per day — the researchers said they observed increased expression of genes that are markers of fat production and inflammation.

Even more troubling, her study found a link between high blood levels of lycopene's chemical cousin, beta - carotene, and an increased risk of aggressive prostate cancer — not enough to justify avoiding carrots and other food sources of beta - carotene but an ominous sign that not all food - derived compounds are necessarily benign when taken at higher doses.

Following additional scrutiny after Vioxx's withdrawal, and the addition of cardiovascular experts to the trial's data safety monitoring board, the DSMB concluded that patients taking a high dose of Celebrex had a 3.4-fold increase in the risk of heart attacks or strokes compared to those on placebo; those on a moderate dose had a 2.5-fold increase in risk.

In a phase 2 trial that included nearly 1,000 adults, the AS03 and MF59 adjuvants (a component that improves immune response of inactivated influenza vaccines) increased the immune responses to two doses of an inactivated H7N9 influenza vaccine, with AS03 - adjuvanted formulations inducing the highest amount of antibody response, according to a study in the July 21 issue of JAMA.

The toxic effects started very soon after PTCs were exposed to HEC, and further increased at higher doses.

The small increase in the high - dose group did not translate into beneficial effects because authors found no difference between the three study groups for changes in spine, average total - hip, average femoral neck or total - body bone mineral density, trabecular bone score, muscle mass or sit - to - stand tests.

Results indicate that calcium absorption increased 1 percent in the high - dose group but decreased 2 percent in the low - dose group and 1.3 percent in the placebo group.

But the accident is likely to cause small, but significant, increases in cancers in populations in a few hotspots exposed to higher radioactive doses.

The World Health Organization is working to increase the percentage of infants who receive at least three doses of pertussis vaccine to 90 percent or higher, especially in developing countries.

Citalopram, the most commonly prescribed drug among patients in the study, was not associated with an increased risk of arrhythmia, even at higher doses.

Some studies have found an increased cancer risk in mice and rats who were fed acrylamide, but those studies used doses between 1,000 and 10,000 times higher than levels that people would be exposed to in food.

«We expected an increase in the glutamate, because it is a chemical that causes damage in high doses and we have already seen brain damage from sleep apnea.

Some of the nanoparticles also cause pro-inflammatory signaling at high doses, and this can increase the permeability of the intestinal model.

And in tracking human disease patterns, she's established a clear link between such low - dose chronic exposure and increases in high blood pressure and heart disease.

Recent studies have shown women with cancer in the left breast are at higher risk of heart disease, and that the risk increases proportionately with the dose of radiation the heart is exposed to during treatment.

By fusing that sequence to three growth factors they were able to increase their binding affinity by 2 - to 100-fold, which could reduce the need for higher doses in the future.

Although both drugs caused increases in dopamine release directly proportional to the administered dose, the researchers found that lower doses of the two substances administered simultaneously resulted in an additive effect on the release of dopamine that was not recorded with higher doses.

A reversal agent works by restoring the drug's access, but most of these agents only work at high doses, which would increase the risk of neurological side effects, says Jane Kelly, a malaria researcher at the Portland Veterans Affairs Medical Center in Oregon.

«Here, we verified convincingly that increased redox active metal ions in cancer cells were responsible for this differential sensitivity of cancer versus normal cells to very high doses of vitamin C.»

Significantly, the effect of PARTICLE in limiting the time and extent of the radiation - induced increase in DNA methylation is more pronounced at lower radiation doses than at higher doses.

Sceptics point out that in Hungary, where parts of the population are exposed to high doses of arsenic in the water, there is as yet no evidence of increased cancers.

The studies (though conducted almost entirely in men) showed that there's a definite interaction between flibanserin and alcohol, with an increased number of side effects such as dizziness and fainting at moderate and high alcohol doses.

Catlin, on the other hand, believes that higher doses taken for longer than a week would increase muscle size measurably.

A multi-center study led by Fred Hutchinson Cancer Research Center has found that high - dose supplementation with both the trace element selenium and vitamin E increase the risk of high - grade prostate cancer.

With caffeine, we have a double negative in that it inhibits an inhibitory neurotransmitter and thus increase levels of arousal and alertness — but higher doses can produce nervousness, anxiety and tachycardia.

The effect of glucocorticoid treatment is most prominent on trabecular bone and is therefore likely to be larger on vertebral bone than on hip bone.3 Glucocorticoids are associated with an increased rate of fracture, and higher doses and longer use of glucocorticoids are associated with higher risks of fracture.4 Compared with patients not taking glucocorticoids, the risk of hip and vertebral fracture among patients taking glucocorticoids is increased by 60 % and 160 %, respectively.4 Among 80 - year - old patients, the hip fracture risk is increased by a magnitude of 2.1 and is independent of BMD.5 Most studies indicate that fracture risk is increased following at least 3 months of treatment with daily doses of 5 mg of prednisolone or more in older men and women.4

«A subgroup analysis that combines data from children in both the single - and multiple - dose studies demonstrated a mean 5 point increase in muscle function score in children who received at least 9 mg of ISIS - SMNRx between the ages of two and 10 who did not have severe scoliosis or baseline HFMSE scores at the extreme low or high ends of the scale.

Therefore, a higher dose and increased vulnerability may quicken the impact of neonicotinoids over time.

Acute insulin stimulation significantly increased the fractional activity FV0.1 of GS in control cultures in the range of 0.1 pmol / l to 0.1 nmol / l (P < 0.05) and in diabetic cultures in the range of 0.1 pmol / l to 1.0 nmol / l (P < 0.05), whereas higher insulin concentrations diminished the effect of acute insulin stimulation in a dose - dependent pattern.

The selective destruction of acinar cells by high dose of L - arginine may be partly attributed to disruption of protein metabolism, increased oxidative stress, and endoplasmic reticulum stress [6].

Traditional treatment of pediatric APL has included high doses of anthracycline, increasing patient's risk for cardiac toxicity.

At the highest dose level, DG031 reduced levels of myeloperoxidase (MPO), higher levels of which have been linked to increased risk of heart attack.

Although p53 protein levels decreased after reaching the maximal level with treatment of 30 nM ActD, phosphorylation of p53 still increased with treatment of high doses (100 and 300 nM) of ActD.

Increases respiration at low doses, while decreases respiration at high doses (PubMed: 25707796, PubMed: 27828947).