Sentences with phrase «higher increased risk»

Compared with women who had never used HRT of any kind, those who used estrogen alone (presumably women who had a hysterectomy) had a significant 1.29-fold higher increased risk of breast cancer.

Smoking, of course, accounted for the highest increased risk at 71.6 % for women and 59.6 % for men.

When an animal is going in for surgery or chemo, or has an autoimmune disease or neoplastic condition [a tumor], or even a chronic immune challenge such as allergies or endocrine / metabolic diseases, they are at a high increased risk to an adverse reaction to any vaccine.

Not exact matches

YELLOWKNIFE, Northwest Territories, May 1 (Reuters)- Bank of Canada Governor Stephen Poloz said on Tuesday there is good reason to believe the central bank can manage the risks of Canada's high household debt, even as he signaled that interest rate hikes will continue, increasing the cost of that debt.

Important factors that could cause actual results to differ materially from those reflected in such forward - looking statements and that should be considered in evaluating our outlook include, but are not limited to, the following: 1) our ability to continue to grow our business and execute our growth strategy, including the timing, execution, and profitability of new and maturing programs; 2) our ability to perform our obligations under our new and maturing commercial, business aircraft, and military development programs, and the related recurring production; 3) our ability to accurately estimate and manage performance, cost, and revenue under our contracts, including our ability to achieve certain cost reductions with respect to the B787 program; 4) margin pressures and the potential for additional forward losses on new and maturing programs; 5) our ability to accommodate, and the cost of accommodating, announced increases in the build rates of certain aircraft; 6) the effect on aircraft demand and build rates of changing customer preferences for business aircraft, including the effect of global economic conditions on the business aircraft market and expanding conflicts or political unrest in the Middle East or Asia; 7) customer cancellations or deferrals as a result of global economic uncertainty or otherwise; 8) the effect of economic conditions in the industries and markets in which we operate in the U.S. and globally and any changes therein, including fluctuations in foreign currency exchange rates; 9) the success and timely execution of key milestones such as the receipt of necessary regulatory approvals, including our ability to obtain in a timely fashion any required regulatory or other third party approvals for the consummation of our announced acquisition of Asco, and customer adherence to their announced schedules; 10) our ability to successfully negotiate, or re-negotiate, future pricing under our supply agreements with Boeing and our other customers; 11) our ability to enter into profitable supply arrangements with additional customers; 12) the ability of all parties to satisfy their performance requirements under existing supply contracts with our two major customers, Boeing and Airbus, and other customers, and the risk of nonpayment by such customers; 13) any adverse impact on Boeing's and Airbus» production of aircraft resulting from cancellations, deferrals, or reduced orders by their customers or from labor disputes, domestic or international hostilities, or acts of terrorism; 14) any adverse impact on the demand for air travel or our operations from the outbreak of diseases or epidemic or pandemic outbreaks; 15) our ability to avoid or recover from cyber-based or other security attacks, information technology failures, or other disruptions; 16) returns on pension plan assets and the impact of future discount rate changes on pension obligations; 17) our ability to borrow additional funds or refinance debt, including our ability to obtain the debt to finance the purchase price for our announced acquisition of Asco on favorable terms or at all; 18) competition from commercial aerospace original equipment manufacturers and other aerostructures suppliers; 19) the effect of governmental laws, such as U.S. export control laws and U.S. and foreign anti-bribery laws such as the Foreign Corrupt Practices Act and the United Kingdom Bribery Act, and environmental laws and agency regulations, both in the U.S. and abroad; 20) the effect of changes in tax law, such as the effect of The Tax Cuts and Jobs Act (the «TCJA») that was enacted on December 22, 2017, and changes to the interpretations of or guidance related thereto, and the Company's ability to accurately calculate and estimate the effect of such changes; 21) any reduction in our credit ratings; 22) our dependence on our suppliers, as well as the cost and availability of raw materials and purchased components; 23) our ability to recruit and retain a critical mass of highly - skilled employees and our relationships with the unions representing many of our employees; 24) spending by the U.S. and other governments on defense; 25) the possibility that our cash flows and our credit facility may not be adequate for our additional capital needs or for payment of interest on, and principal of, our indebtedness; 26) our exposure under our revolving credit facility to higher interest payments should interest rates increase substantially; 27) the effectiveness of any interest rate hedging programs; 28) the effectiveness of our internal control over financial reporting; 29) the outcome or impact of ongoing or future litigation, claims, and regulatory actions; 30) exposure to potential product liability and warranty claims; 31) our ability to effectively assess, manage and integrate acquisitions that we pursue, including our ability to successfully integrate the Asco business and generate synergies and other cost savings; 32) our ability to consummate our announced acquisition of Asco in a timely matter while avoiding any unexpected costs, charges, expenses, adverse changes to business relationships and other business disruptions for ourselves and Asco as a result of the acquisition; 33) our ability to continue selling certain receivables through our supplier financing program; 34) the risks of doing business internationally, including fluctuations in foreign current exchange rates, impositions of tariffs or embargoes, compliance with foreign laws, and domestic and foreign government policies; and 35) our ability to complete the proposed accelerated stock repurchase plan, among other things.

YELLOWKNIFE, Northwest Territories, May 1 - Bank of Canada Governor Stephen Poloz said on Tuesday there is good reason to believe the central bank can manage the risks of Canada's high household debt, even as he signaled that interest rate hikes will continue, increasing the cost of that debt.

Every rollout has issues, but planning can mitigate the risk of costly problems, so prepare to solve issues immediately, such as increasing supply if demand is higher than expected.

As interest rates for these seemingly safer investments increase, they become more attractive to investors, and as such, the incentive for investors to plow funds into high - risk opportunities decreases.

Appetite for risk has increased among money managers to a new high, according to the latest fund manager survey by Bank of America Merrill Lynch (BoAML).

Diets high in fat and heavy in dairy and high - glycemic sugars, like bread and pasta, have been linked to increased risks of acne.

Combined with the loose - money policies at all the major central banks, high inflation is an increasing risk.

Published in Psychological Science, the group concluded that «high - power posers experienced elevations in testosterone, decreases in cortisol, and increased feelings of power and tolerance for risk.»

Moody's Investors Service maintained its ratings for Desjardins but said the transaction creates risks, mainly because of the increased exposure to the high - risk Ontario personal auto insurance market, which will make its insurance operations «a less predictable source of earnings.»

For one thing, margarine is high in Omega 6 fatty acids, which has been linked «to an increased risk for heart disease and may contribute to cancer, asthma, osteoporosis, inflammation, depression and other ailments.»

Actual results, including with respect to our targets and prospects, could differ materially due to a number of factors, including the risk that we may not obtain sufficient orders to achieve our targeted revenues; price competition in key markets; the risk that we or our channel partners are not able to develop and expand customer bases and accurately anticipate demand from end customers, which can result in increased inventory and reduced orders as we experience wide fluctuations in supply and demand; the risk that our commercial Lighting Products results will continue to suffer if new issues arise regarding issues related to product quality for this business; the risk that we may experience production difficulties that preclude us from shipping sufficient quantities to meet customer orders or that result in higher production costs and lower margins; our ability to lower costs; the risk that our results will suffer if we are unable to balance fluctuations in customer demand and capacity, including bringing on additional capacity on a timely basis to meet customer demand; the risk that longer manufacturing lead times may cause customers to fulfill their orders with a competitor's products instead; the risk that the economic and political uncertainty caused by the proposed tariffs by the United States on Chinese goods, and any corresponding Chinese tariffs in response, may negatively impact demand for our products; product mix; risks associated with the ramp - up of production of our new products, and our entry into new business channels different from those in which we have historically operated; the risk that customers do not maintain their favorable perception of our brand and products, resulting in lower demand for our products; the risk that our products fail to perform or fail to meet customer requirements or expectations, resulting in significant additional costs, including costs associated with warranty returns or the potential recall of our products; ongoing uncertainty in global economic conditions, infrastructure development or customer demand that could negatively affect product demand, collectability of receivables and other related matters as consumers and businesses may defer purchases or payments, or default on payments; risks resulting from the concentration of our business among few customers, including the risk that customers may reduce or cancel orders or fail to honor purchase commitments; the risk that we are not able to enter into acceptable contractual arrangements with the significant customers of the acquired Infineon RF Power business or otherwise not fully realize anticipated benefits of the transaction; the risk that retail customers may alter promotional pricing, increase promotion of a competitor's products over our products or reduce their inventory levels, all of which could negatively affect product demand; the risk that our investments may experience periods of significant stock price volatility causing us to recognize fair value losses on our investment; the risk posed by managing an increasingly complex supply chain that has the ability to supply a sufficient quantity of raw materials, subsystems and finished products with the required specifications and quality; the risk we may be required to record a significant charge to earnings if our goodwill or amortizable assets become impaired; risks relating to confidential information theft or misuse, including through cyber-attacks or cyber intrusion; our ability to complete development and commercialization of products under development, such as our pipeline of Wolfspeed products, improved LED chips, LED components, and LED lighting products risks related to our multi-year warranty periods for LED lighting products; risks associated with acquisitions, divestitures, joint ventures or investments generally; the rapid development of new technology and competing products that may impair demand or render our products obsolete; the potential lack of customer acceptance for our products; risks associated with ongoing litigation; and other factors discussed in our filings with the Securities and Exchange Commission (SEC), including our report on Form 10 - K for the fiscal year ended June 25, 2017, and subsequent reports filed with the SEC.

«Often, high - grade bonds in an investment portfolio increase its risk.»

A new study making the rounds suggests that high intake of B vitamins is associated with an increased risk for lung cancer.

Isolation also increases the risk of high blood pressure and disease, according to the National Institutes of Health.

Other reasons for an increase include heading off a deflationary debt spiral, and conversely, the risk of very high inflation.

We believe that higher financial risk stemming from management's willingness to increase leverage for acquisitions is mitigated by its disciplined approach — as demonstrated by the unsuccessful bid for Casey's in 2010 and resistance to a higher bid for Statoil.

Twenty - seven percent of employee - introduced, third - party cloud applications, intended to open up new business opportunities and increase efficiencies, were categorized as high risk and created significant security concerns.

In the 1990s this zone increased by almost 11 percent in California, Oregon and Washington, adding over 1 million housing units - mostly in areas of moderate to high fire risk.

«We observed a 49 percent increased risk of lung cancer among subjects with the highest daily glycemic index,» author of new study says.

High triglycerides increase cardiovascular events, medical costs, and resource utilization in a real - world analysis of statin - treated patients with high cardiovascular risk and well - controlled low - density lipoprotein cholesterol [abstraHigh triglycerides increase cardiovascular events, medical costs, and resource utilization in a real - world analysis of statin - treated patients with high cardiovascular risk and well - controlled low - density lipoprotein cholesterol [abstrahigh cardiovascular risk and well - controlled low - density lipoprotein cholesterol [abstract].

Poloz said there is good reason to believe the central bank can manage the risks of Canada's high household debt, even as he signaled that interest rate hikes will continue, increasing the cost of that debt.

These risks include, in no particular order, the following: the trends toward more high - definition, on - demand and anytime, anywhere video will not continue to develop at its current pace or will expire; the possibility that our products will not generate sales that are commensurate with our expectations or that our cost of revenue or operating expenses may exceed our expectations; the mix of products and services sold in various geographies and the effect it has on gross margins; delays or decreases in capital spending in the cable, satellite, telco, broadcast and media industries; customer concentration and consolidation; the impact of general economic conditions on our sales and operations; our ability to develop new and enhanced products in a timely manner and market acceptance of our new or existing products; losses of one or more key customers; risks associated with our international operations; exchange rate fluctuations of the currencies in which we conduct business; risks associated with our CableOS ™ and VOS ™ product solutions; dependence on market acceptance of various types of broadband services, on the adoption of new broadband technologies and on broadband industry trends; inventory management; the lack of timely availability of parts or raw materials necessary to produce our products; the impact of increases in the prices of raw materials and oil; the effect of competition, on both revenue and gross margins; difficulties associated with rapid technological changes in our markets; risks associated with unpredictable sales cycles; our dependence on contract manufacturers and sole or limited source suppliers; and the effect on our business of natural disasters.

In some scenarios, simulated training is superior to the real thing: Not only does it eliminate the risk of accidents in high - risk jobs, it has been proven to shorten instruction periods and increase people's abilities to remember what they learn.

As a result, it is now clear that the U.S. is in the latter stages of the multi-year credit cycle, a period when rising corporate leverage negatively affects returns to corporate debt as investors demand higher risk premiums to compensate for the greater volatility created by increased leverage.

Coffee consumption was also consistently associated with significantly lower risk of gallstone disease.25 A non-linear dose response was also apparent, though risk sequentially reduced as consumption increased from two to six cups a day.25 High versus low consumption was associated with a marginally higher risk of gastro - oesophageal reflux disease, but this did not reach significance.64

Metabolic syndrome is a cluster of conditions including high blood pressure, high blood sugar, abnormal cholesterol and excess waistline fat that is known to increase one's risk of heart disease, stroke and diabetes.

With the potential for higher U.S. budget deficits and debt risking dollar strength, central banks around the globe could be motivated to increase their gold holdings, says Credit Suisse.

The IMF's October, 2012 World Economic Outlook (WEO), «Coping with High Debt and Sluggish Growth» is a must read for anyone who wants a realistic and independent assessment of global economic prospects, the challenges confronting policymakers, and the risks to global economic growth that are increasing by the month.

Credit spreads will increase for all sorts of corporates as the number of distressed corporates will increase and risk aversion will be higher.

The increase in the ties between national financial systems, the greater sophistication of financial markets and financial market instruments allow risks to be shared more broadly and capital to flow to where the returns are expected to be the highest.

Many lenders consider the increased flexibility of a business credit line higher - risk financing than a more traditional term loan because the business is borrowing in the future based upon their creditworthiness today.

If you can't stomach the risk of the higher potential losses in stocks, lower the amount you have in stocks and increase your allocation to bonds.

The losses in major Asian stock markets on Wednesday morning tracked losses on Wall Street overnight, and with increasing risks seen in tech shares, weak copper prices, and high US Treasury yields.

He realized that in by investing in companies with a high margin of safety, he reduced his risk while simultaneously increased his potential return.

Risks associated with the Consumer Discretionary sector include, among others, apparel price deflation due to low - cost entries, high inventory levels and pressure from e-commerce players; reduction in traditional advertising dollars; increasing household debt levels that could limit consumer appetite for discretionary purchases; declining consumer acceptance of new product introductions; and geopolitical uncertainty that could impact consumer sentiment.

As Jens Weidmann, the President of the German Bundesbank objected about this plan last week, «It is tied to higher risks of losses and to increased sharing of risks.

One area of uncertainty relates to wages growth, where there is a risk that current labour market tightness will result in higher - than - expected wage increases.

The low unemployment rate and decent economic growth will help the economy withstand higher rates, though risks are increasing.

Such restrictions could materially raise the cost of intermediation and increase the risk that the demand for high - quality collateral exceeded supply.

Western allies press Trump to maintain nuclear deal with Iran: Reuters US intelligence monitors Iranian cargo shipments into Syria: CNN A trade war is a major risk for China's debt - ridden economy: CNBC Federal judge orders gov» t must accept new DACA immigration applications: WaPo Unification of Koreas still unlikely as leaders prepare to meet: Reuters US Consumer Confidence Index rebounded in April after March decline: CB New home sales in US increased to 4 - month high in March: MarketWatch Richmond Fed Mfg Index turns negative for first time since 2016: Bond Buyer S&P Case - Shiller Home Price Index surged in Feb, up 6.3 % y - o - y: CNBC Federal Housing Finance Agency: US house prices continued to rise in Feb: HW Corp bonds with lowest investment - grade rating look vulnerable: Bloomberg 10 - year Treasury yield reaches 3.0 % for first time since 2014: CNN Money

New Data Shows iRhythm's ZIO Service Increases Detection And Diagnosis Of Silent Atrial Fibrillation In High - Risk Patients

Synopsis: Offering a complete course of instruction, «Higher Probability Commodity Trading: A Comprehensive Guide to Commodity Market Analysis, Strategy Development, and Risk Management Techniques Aimed at Favorably Shifting the Odds of Success» takes readers explains commodity markets by shedding light on topics rarely discussed in trading literature from a unique perspective, with the intention of increasing the odds of success for market participants.

High interest costs during difficult financial periods can increase the risk of insolvency.

While there is a risk BEP doesn't match my assumption due to the high payout ratio, I still consider this number as the company showed more commitment to increase its payouts than keep its FFO payout ratio in order.

Considering the high correlation between green bonds and core fixed income, investors have the possibility to reallocate part of their core fixed income allocation to green bonds in order to increase diversification and «green» their portfolio with a minimal impact on the risk / return profile of their portfolio.

The investment manager generally will increase the exposure of the Fund to interest rate risk in environments where the return expected to be derived from that risk is high, and generally will reduce exposure to interest rate risk when the return expected to be derived from that risk is unfavorable.