Not exact matches
Using the correct
numbers for the risk
of miscarrying after an amniocentesis, the natural conclusion would seem to be that moms whose risk
of having a baby with a
chromosome disorder is less than 1 in 400 should not have an amniocentesis (since the odds
of the test causing a miscarriage would be
higher).
During periods
of high stress, he says, men produce less testosterone, which can reduce the
number and quality
of the «male» sperm, which carry a Y sex
chromosome.
Among its oddities: 52
chromosomes, including 10 sex
chromosomes, as well as the
highest number of repeated segments in the genome
of any mammal sequenced so far.
Another reason that determining the genetic sequence
of the Y
chromosome is so difficult is that it is composed
of an unusually
high number of repeated sequences — regions where the sequence
of As, Ts, Cs, and Gs are identical, or nearly identical, for thousands or millions
of bases in a row.
The researchers then confirmed that the
number of singly paired
chromosomes — also called univalents — was
higher in older mouse and even human egg cells, indicating that age - related segregation errors could be tracked back to increased
numbers of prematurely separated
chromosome pairs.
Venken first sought a vector that could handle large amounts
of DNA efficiently, settling on a bacterial artificial
chromosome, which was designed a couple years ago and is known to maintain only a few copies
of the DNA (though it can produce a
high number of copies if it is induced).
As the authors also observed in previous works, some aphids showed different
chromosome numbers also comparing cells belonging to a same individual «forgetting» that
chromosome instability within individuals should be typical
of malignant cells and not
of healthy insects showing a
high reproductive rate.
Surveillance that is not stringent enough, on the other hand, would allow eggs with a lot
of jumping gene - related errors to survive, and lead to a
high level
of birth defects, such as those caused by an incorrect
number of chromosomes in the offspring.
A disproportionately
high number of mendelian diseases are documented for the X
chromosome.
Non-physiological alterations in
chromosome number are well - established contributors to human disorders: they are responsible
of a
high percentage
of miscarriages and a panel
of diseases including Down syndrome, developmental disorders and cancer.
A. Bar heights indicate the degree to which each
chromosome contains an unexpectedly
high number of differentially methylated promoters.