Sentences with phrase «higher number of mutations»

«What is most surprising is the high number of mutations.

A new study by researchers at Karolinska Institutet in Sweden shows how an unexpectedly high number of mutations in the stem cells of muscles impair cell regeneration.

In contrast, Bortvin and Malki discovered that female mice allow transposon movement to take place, but then get rid off immature eggs harboring the highest number of mutations before the female mouse is even born.

Not exact matches

Single and triple mutants correspond to «x,» and unmutated, double and four - tuple mutants correspond to «y.» The odd number of mutations produce «x» and even numbers produce «y.» The mutants in the order are ranked from high to low fitness.

ETH researchers have now shown that the high estimated mutation rates at the start of the epidemic were due to the limited number of virus samples at the time in combination with the computer models used, which calculate the estimates using genetic data from virus samples and from underlying assumptions.

When they sequenced the iPS cell lines, they found higher numbers of mitochondrial DNA mutations, particularly in cells from patients older than 60.

The study builds on Polyak's earlier research finding that women already identified as having a high risk of developing cancer — namely those with a mutation called BRCA1 or BRCA2 — or women who did not give birth before their 30s had a higher number of mammary gland progenitor cells.

Is it true that physical exercise from a young age clears out cells with many mutations, or does it result in the generation of a higher number of such cells?

The team also found that the flightless cormorants have an abnormally high number of genetic mutations affecting cilia — small, hair - like structures that protrude from cells and regulate everything from normal development to reproduction.

CCG uses high - throughput techniques to identify and study mutations, large rearrangements of the genome, increases and decreases in DNA copy number, chemical modifications to DNA, and changes in the expression of RNA and proteins.

Its characteristically low mutational burden, high copy number and structural variants, and unique driver mutation prevalence are important in helping us understand the natural history of the disease and its response to various therapies.

Most tumors contain fewer than 10 of the driver mutations, but the number of total mutations — passenger and driver — can climb far higher, from a dozen or so in neuroblastoma to approximately 200 in lung cancer.

Clinical studies identify FLT3 ITD mutations associated with higher numbers of leukemic cells, increased incidence of relapse and decreased overall survival.

«Simultaneous mutation detection, copy number measurement, and digital gene expression profiling of high - grade serous ovarian cancer FFPE samples using Hyb & SeqTM targeted sequencing technology»

Laws of population genetics predict that, on a purely theoretical ground, such a high number of genes should translate into an extremely elevated frequency of unaffected carriers of mutations.

We found much higher variance in RND values for intronic fragments consisting of a reduced number of sites, likely due to stochastic variation in the mutation process.

Association and prognostic significance of BRCA1 / 2 - mutation status with neoantigen load, number of tumor - infiltrating lymphocytes and expression of PD - 1 / PD - L1 in high grade serous ovarian cancer.

To understand the selection mechanism behind mutations, network - based studies were used to estimate the importance of a mutated protein compared to non-mutated ones in signalling and protein — protein interaction networks.10, 11,12,13 Proteins mutated in cancer were found having a high number of interacting partners (i.e., a high degree of connectivity), which indicates high local importance.10 Mutated proteins are also often found in the centre of the network, in key global positions, as quantified by the number of shortest paths passing through them if all proteins are connected with each other (i.e., they have high betweenness centrality; hereafter called betweenness).11, 12 Mutated proteins also have high clustering coefficients, which means their neighbours are also neighbours of each other.10, 13 Moreover, neighbourhood analysis of mutated proteins have been previously successfully used to predict novel cancer - related genes.14, 15 However, to the best of our knowledge, no study has concentrated particularly on the topological importance of first neighbours of mutated proteins in cancer, and their usefulness as drug targets themselves.

A recent study of over 35,000 breast cancer survivors published in the American Cancer Society's journal Cancer found that multi-gene testing can reveal DOUBLE the number of high - risk gene mutations as compared to testing BRCA1 / 2 alone.1

Some families have had a high number of cases, particularly Maine coon cats, where a mutation that is associated with the disease was identified in one large family.

Early spaying may therefore, reduce occurrence of malignant lesions because the procedure removes the source of the hormones that cause some mammary cells to lose growth control, which puts these dividing cells at high risk for mutation and malignant transformation by environmental carcinogens.In fact, recent reports have identified activation of a specific oncogene in a number of canine mammary tumors.