Sentences with phrase «highest risk alleles»

This tells us that heritability contributes to risk, and so it may be possible to reduce the incidence by eliminating the highest risk alleles from the population.

Not exact matches

Individuals were classified as high risk for Alzheimer's if a DNA test identified the presence of a genetic marker — having one or both of the apolipoprotein E-epsilon 4 allele (APOE - e4 allele) on chromosome 19 — which increases the risk of developing the disease.

Women with two copies of s fared even worse: They had bones that were 4 % less dense — and faced a 280 % higher risk of fracture — than did women without any s alleles, says team member Andre Uitterlinden, a molecular geneticist at Erasmus University in Rotterdam, the Netherlands.

The research by scientists at Children's Hospital Los Angeles and Columbia University shows a link between a particular allele for serotonin found at a higher frequency in those at risk of depression because of family history, and those who go on to develop major depressive disorder.

Furthermore, sex - specific differences in gene polymorphism are suggested by one study showing that diabetic women carrying ACE D allele have a higher risk for development of diabetic nephropathy, which was not seen in diabetic men (Table 2)(331).

In addition, the clinical sensitivity of tests for common risk alleles is not necessarily high.

At low - density lipoprotein receptor (LDLR), carriers of rare non-synonymous mutations were at 4.2-fold increased risk for MI; carriers of null alleles at LDLR were at even higher risk (13-fold difference).

AFFECTED dogs carry two copies of the IG - PRA1 risk allele and thus have the genetic make - up that indicates they are at HIGH RISK to develop PRA due to the IG - PRA1 risk allrisk allele and thus have the genetic make - up that indicates they are at HIGH RISK to develop PRA due to the IG - PRA1 risk allRISK to develop PRA due to the IG - PRA1 risk allrisk allele.

For each of the three genes, one allele (variant) is found at unusually high frequency in dogs that have been treated for bloat, and the presence of any one of these «risk» alleles triples the chance that the dog will experience bloat at some time in its life.

Children who carried copies of the A allele of the single nucleotide polymorphism rs10482672 had the highest risk of externalizing psychopathology if they were in the control arm of the trial and the lowest risk of externalizing psychopathology if they were in the treatment arm.

This direction of the association, however, is concordant with the idea that the minor allele of SNP rs11568817 engenders a risk for higher levels of CU traits, which in turn were found to be associated with lower levels of peripheral serotonin.

Adolescents living in high - risk families who carried at least one DRD4 long allele and were assigned to the control condition evinced greater escalations in drug use than did (a) adolescents who lived in high - risk families, carried the DRD4 long allele, and were assigned to AIM, or (b) adolescents assigned to either condition who carried no DRD4 long alleles.

As expected, over a twenty - seven - month period, the best predictor of outcomes was the DRD4 × Family Risk × AIM interaction, with the impact of the intervention greatest for youth from contexts of high family risk who had the long - allele genotRisk × AIM interaction, with the impact of the intervention greatest for youth from contexts of high family risk who had the long - allele genotrisk who had the long - allele genotype.