Leishmania, a major protozoan parasite, is emerging as a new model for aneuploidy, since in vitro - cultivated strains are
highly aneuploid, with interstrain diversity and intrastrain mosaicism.
Wing primordia subjected to CIN are characterised by tumor - like overgrowths, metastatic behavior and malignancy to the host upon blockade of the apoptotic machinery, and this tumorigenic response relies mainly on the production of
highly aneuploid cells that delaminate from the epithelium and activate a JNK - dependent transcriptional response.
In a retrospective analysis of clinical trial data, they found that melanoma patients with
highly aneuploid tumors were less likely to benefit from immune checkpoint blockade therapy than patients whose tumors showed fewer chromosomal disruptions.
Not exact matches
Moreover, many human tumors have
highly abnormal numbers of chromosomes (that is, they are
aneuploid), with initial chromosomal loss participating in the early steps of the transformation cascade in inherited cancers caused by heterozygous mutation in tumor suppressor genes and the more widespread aneuploidy characteristic of advance tumors thought to drive acquisition of malignant growth properties.??