NSG ™ variants are the most
highly immunodeficient mice and the models of choice for cancer xenograft modeling, stem cell...
Using
the highly immunodeficient NSG ™ mice [NOD.Cg - Prkdcscid Il2rgtm1Wjl / SzJ (005557)-RSB- as a host, they injected hu - PBMCs directly into the spleen along with HIV engineered to express luciferase (HIV - LucR).
Besides, common manipulations utilized by scientists in various fields to dissect the cellular and molecular basis of selected diseases make use of
highly immunodeficient strains, whose reliability depends on the stringency of the SOPF measures adopted by local housing and breeding facilities.
Not exact matches
However, their initial finding demonstrated that progenitor derived from iPSCs generated using lentiviral gene transduction led to the high incidence of
highly aggressive tumors in
immunodeficient mice after transplantation under the kidney capsule.
Because they arise in
immunodeficient hosts, they're also
highly immunogenic.