Sentences with phrase «highly tumorigenic»

In this study, we focused on PC3 cells, which lack androgen receptor expression, are completely undifferentiated, are highly tumorigenic and metastatic, and have been considered the most malignant prostate cancer cell line (27 — 29).

Animals receiving either clone failed to develop tumors, whereas the combination was highly tumorigenic.

We also found that cells derived from this novel subpopulation form colonies readily, are highly tumorigenic in immune - deficient mice, and exhibit both stem - like and EMT phenotypes.

Together, our results reinforce the idea that EMT and stem cell factors work cooperatively in highly tumorigenic cancer subpopulations and raise interesting questions about their contribution to the increased metastatic capability observed in the cycling hypoxia - selected subpopulation.

Not exact matches

Wing primordia subjected to CIN are characterised by tumor - like overgrowths, metastatic behavior and malignancy to the host upon blockade of the apoptotic machinery, and this tumorigenic response relies mainly on the production of highly aneuploid cells that delaminate from the epithelium and activate a JNK - dependent transcriptional response.