Sentences with phrase «highly uncertain environment»

• Any acquiror must take on the Company's cash burn and fund the Company in a highly uncertain environment; and

Despite what most observers see as highly uncertain environment, market expectations of near term volatility are near record lows suggesting scope for sudden disillusionment.

Not exact matches

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

However, the oil's fate is highly uncertain, as it may burn, evaporate, or mix into the surface ocean and contaminate the environment for an extended duration.

At the science - policy interface where the science is highly uncertain, understanding of the postnormal environment for science can help avoid situations of overconfidence in the science and keep the focus on understanding and characterizing the uncertainty.

Computer models of a warming climate indicate that conditions may become more conducive to severe thunderstorms in some regions.11 Thunderstorms provide a favorable environment for tornado formation; but tornadoes also require wind shear, a highly uncertain element in climate models.

As highlighted by the recent Global Witness report «A Conflict of Interests: The uncertain future of Burma's forests», the timber trade in Burma is unregulated, highly destructive of the environment and intertwined with corruption, illegality, and armed conflict.

So, all in all, it appears highly uncertain that AGW, caused principally by human CO2 emissions, has been the primary cause of past warming, or that it represents a serious potential threat to humanity or our environment.

Employers have an indisputable duty to provide a safe and harassment free work environment, but the scope of the «workplace» and the limits of the duty are highly uncertain when employees are targeted by «trolls» or other internet miscreants.

I look forward to collaborating with the firm's other highly experienced attorneys to help develop in a positive manner the legal infrastructure for companies to excel in this space and uncertain legal environment.»