Sentences with phrase «highly uncertain future»

On the one hand, in a highly uncertain future, broad skill formation offers the best protection against displacement, especially in the skills that machines will not do anytime soon.

Not exact matches

«The precise parameters of the U.K.'s future relationship with the European Union remained highly uncertain and it seemed likely that asset prices would remain sensitive to perceived developments in the outlook in the months ahead,» the Bank of England said through the minutes of the policy committee's meeting.

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

Until the middle of the eighth century Israel's future, while uncertain and often highly insecure, could be seen as in continuum with the present, as holding in prospect essentially more of the same.

According to a report by Spanish publication Don Balon, Real Madrid are eyeing Christian Pulisic as a summer replacement for Gareth Bale, whose future at the Bernabeu is highly uncertain.

With Mourinho's appointment, a lot of concerns revolved around Rooney, as his future at the club was highly uncertain.

The future impacts of anthropogenic global change on marine ecosystems are highly uncertain, but insights can be gained from past intervals of high atmospheric carbon dioxide partial pressure.

It's safe to say that the future supply and demand of bitcoin are highly uncertain, but the expectations of future supply and demand are factored into the current price.

The future of the North American Free Trade Agreement (NAFTA) remains highly uncertain at this juncture in the Trump presidency and the combination of oil prices stalling around US $ 50 / barrel and a declining trend in U.S. car sales points to a weaker contribution from trade in the second quarter.

The ratings on GM's debt reflect a highly speculative company with an uncertain future.

Just like with predicting future returns, predicting future risks for any given period is a highly uncertain exercise, and these future risk estimates are just central tendencies.

Future changes in the polar vortex appear to be quite model dependent, and so predictions of this aspect of polar change are highly uncertain.

I'll accept, for the purposes of this discussion, that at some — highly uncertain — time in the future some of the «catastrophic» melting events will indeed take place due to the GW.

«Future generations will wonder in bemused amazement that the early 21st century's developed world went into hysterical panic over a globally averaged temperature increase of a few tenths of a degree, and, on the basis of gross exaggerations of highly uncertain computer projections combined into implausible chains of inference, proceeded to contemplate a roll - back of the industrial age,» Lindzen was quoted, offering praise for Christopher C. Horner's Politically Incorrect Guide to Global Warming and Environmentalism.

The future is highly uncertain, everyone will have a different view about it (if they think about it at all), and we will all be wrong.

We know the climate sensitivity to radiative forcing to be about 3 °C per 4 W / m2 of forcing to within something like a 10 % uncertainty, base on current climate modeling and the geological record (see Hansen et al., 2008) for details http://pubs.giss.nasa.gov/abs/ha00410c.html The natural (unforced) variability of the climate system is going to remain highly uncertain for the foreseeable future.

«[I] t is not possible to tell how much of the modest recent warming can be ascribed to human influences,» wrote Happer, Koonin and Lindzen, «and there have been no detrimental changes observed in most salient climate variables and projections of future changes are highly uncertain.»

But in the face of climate change, long - term planning (over several decades) is needed for a future that is highly uncertain.

Quantitative estimates of future rates of sea level rise are highly uncertain (independent of any uncertainties about future emissions), and the assessments have over-hyped the high estimates

«There have been no detrimental changes observed in the most salient climate variables and today's projections of future changes are highly uncertain,» reads a separate brief filed by Princeton University physicist William Happer, New York University physicist Steven Koonin and Massachusetts Institute of Technology climatologist Richard Lindzen.

Numerous studies have tackled the future environmental impact of battery - electric vehicles; the resulting assessments are highly uncertain.

As highlighted by the recent Global Witness report «A Conflict of Interests: The uncertain future of Burma's forests», the timber trade in Burma is unregulated, highly destructive of the environment and intertwined with corruption, illegality, and armed conflict.

Thus, predictions of future trajectories of pH in coastal ecosystems are still highly uncertain even though model predictions can provide reliable predictions for the future trajectories of open - ocean pH and, thereby, the open - ocean end - member affecting coastal pH. Moreover, we argue that even the expectation that the component of coastal pH change associated with OA from anthropogenic CO2 will follow the same pattern as that in the open ocean is not necessarily supported.

«Given the large variability in discharge and SMB observed within the past decade and the potential for unaccounted positive feedback within the ice - climate system, however, the contribution of GrIS discharge to future sea level rise remains highly uncertain.»

One of the most vexing aspects of predicting climate change, of course, is that future outcomes are highly uncertain.

On one hand, the reduction in global SO2 emissions reduces the role of sulfate aerosols in determining future climate toward the end of the 21st century and therefore reduces one aspect of uncertainty about future climate change (because the precise forcing effect of sulfate aerosols is highly uncertain).

Risk of natural disturbances makes future contribution of Canada's forests to the global carbon cycle highly uncertain.

``... the amplitude and even the sign of cloud feedbacks was noted in the TAR as highly uncertain, and this uncertainty was cited as one of the key factors explaining the spread in model simulations of future climate for a given emission scenario.

«We are in effect forced to make current decisions about highly uncertain events in the distant future even though these estimates are highly speculative and are almost sure to be refined over the coming decades.»

6.34 Our starting point has been to recognise that, while the status of electronic wills is currently uncertain, it is highly likely that their use will become commonplace in the future.

It's obvious that the future of Obamacare is highly uncertain.

Pro Bowl Bitcoinist The future is always uncertain, even for highly paid professional athletes.