Sentences with phrase «highly uncertain times»

Sometimes it's better to play things safe during highly uncertain times.

In highly uncertain times, it is very important to keep things in perspective.

Not exact matches

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

It is also highly uncertain whether it can all be set up in time.

Changes in insolation are also thought to have arisen from small variations in solar irradiance, although both timing and magnitude of past solar radiation fluctuations are highly uncertain (see Chapters 2 and 6; Lean et al., 2002; Gray et al., 2005; Foukal et al., 2006).

«Once Upon a Time in Anatolia «After doing tiny, highly personal art films for a little over a decade, Nuri Bilge Ceylan threw a curveball with «Three Monkeys,» an Andrei Tarkovsky - thriller goulash that retained his love for human behavior while combining a meatier plot and a lurking, uncertain anxiety.

I'll accept, for the purposes of this discussion, that at some — highly uncertain — time in the future some of the «catastrophic» melting events will indeed take place due to the GW.

«Both [Fall et al. 2011 and Menne et al. 2010](and cited by Muller et al) do an analysis over a thirty year time period while the Muller et al paper uses data for comparison from 1950 — 2010... I see this as a basic failure in understanding the limitations of the siting survey we conducted on the USHCN, rendering the Muller et al paper conclusions highly uncertain, if not erroneous... I consider the paper fatally flawed as it now stands, and thus I recommend it be removed from publication consideration by JGR until such time that it can be reworked... it appears they have circumvented the scientific process in favor of PR.»

In the case of pricing catastrophe exposure, the insurer or reinsurer is faced with the challenge of settling on a specific price for a specified time period for an exposure that has a highly uncertain expected value.

No - I also don't doubt that ACO2 will warm the climate if all other conditions remain unchanged (which is highly unlikely to happen in the actual system), but am uncertain about the magnitude / timing of the effect in the real climate system and whether any change will lead to conditions that are better or worse for the US or the planet overall.

Yet action to address the risk is complicated because of what Wagner and Weitzman call the Big Four problems: Any one country's effort to prevent climate change alone would be ineffective; political systems struggle to address long - term challenges; by the time humanity decides to act aggressively, it may be too late; and the risks are highly uncertain, which makes them easy to dismiss.

As stated many times, the period before 1940 remains highly uncertain due to a lack of good data.

We are proud to offer you an exceptional team of attorney - mediators, as well as highly trained support staff that will help you navigate these uncertain times.

«Given the natural tendency to stop spending in uncertain and turbulent times — it happened during the Gulf War and helped to bring on a recession — it's highly probable that consumers will pull back consumption again, particularly of durable, big - ticket goods like new home purchases,» said Robert Van Order, Freddie Mac's chief economist.

Since the timing of the disposition of foreclosed properties can be highly uncertain, we will witness choppy price movements as individual metro markets stabilize.