Sentences with phrase «hippocampal bdnf»

Thus the rat hippocampal EEG oscillation should not, strictly speaking, have been called a «theta rhythm».

Cell lysates of hippocampal tissue from the aged huAPP / PS1 and control mice were analyzed for an effect of J147 on the APP processing pathway by immunoblotting with antibodies against BACE (D) and APP (E).

Their findings provoked widespread interest, in part because they related hippocampal activity to arousal, which was at that time the hottest topic in neuroscience.

Hippocampal tissue from the aged huAPP / PS1 mice was analyzed for the effect of J147 treatment on Aβ levels.

They were not able to follow up on these initial observations, and it was not until 1954 that further information became available, in a very thorough study by John D. Green and Arnaldo Arduini that mapped out the basic properties of hippocampal oscillations in cats, rabbits, and monkeys (Green and Arduini, 1954).

Based on evidence from electrophysiological studies showing that both synaptic plasticity and strength of inputs to hippocampal region CA1 vary systematically with ongoing theta oscillations (Hyman et al., 2003; Brankack et al., 1993), it has been suggested that the theta rhythm functions to separate periods of encoding of current sensory stimuli and retrieval of episodic memory cued by current stimuli so as to avoid interference that would occur if encoding and retrieval were simultaneous.

Bergersen LH, Morland C, Ormel L, Rinholm JE, Larsson M, Wold JF, Røe AT, Stranna A, Santello M, Bouvier D, Ottersen OP, Volterra A, Gundersen V (2012) Immunogold detection of L - glutamate and D - serine in small synaptic - like microvesicles in adult hippocampal astrocytes Cereb Cortex, 22 (7), 1690 - 7 PubMed 21914633

The «hippocampal theta rhythm» is a strong oscillation that can be observed in the hippocampus and other brain structures in numerous species of mammals including rodents, rabbits, dogs, cats, bats, and marsupials.

We utilize FRET spectroscopy, high - resolution optical imaging, electrophysiology, molecular biology and biochemistry to explore experience - dependent mechanisms regulating the number and plasticity of hippocampal synapses under physiological and pathological conditions.

Cortical theta oscillations were observed during the transition from sleep and during quiet wakefulness; however, the authors were unable to find any correlation between hippocampal and cortical theta waves, and concluded that the two processes are probably controlled by independent mechanisms.

Later, hippocampal oscillations of the same type were observed in rats; however, the frequency of rat hippocampal EEG oscillations averaged about 8 Hz and rarely fell below 6 Hz.

In general, it is not safe to assume that observations of «theta» in the human EEG have any relationship to the «hippocampal theta rhythm».

Takumi Y, Ramirez - Leon V, Laake P, Rinvik E, Ottersen OP (1999) Different modes of expression of AMPA and NMDA receptors in hippocampal synapses.

Green and Arduini described an inverse relationship between hippocampal and cortical activity patterns, with hippocampal rhythmicity occurring alongside desynchronized activity in the cortex, whereas an irregular hippocampal activity pattern was correlated with the appearance of large slow waves in the cortical EEG.

Direct projections from the septal area to hippocampal interneurons also play a role in generating theta waves, but their influence is much smaller than that of the entorhinal inputs (which are, however, themselves controlled by the septum).

(C) AD mice on the J147 diet (black box) spent much more time freezing on Day 2, demonstrating a significant improvement in hippocampal related memory compared to AD mice on the control diet (white box).

In humans, hippocampal theta rhythm has been observed and linked to memory formation [1][2] and navigation.

When they looked at brains from these mice, the researchers noticed that hippocampal nerves that were between 1 and 2 months old could dramatically increase or decrease the amount of signaling chemicals they receive from neighboring nerves.

This EEG pattern is known as the hippocampal theta rhythm.

Title: The hippocampal to prefrontal cortex circuit in mice: a promising electrophysiological signature in models for psychiatric disorders Author: A. Tripathi et al..

Aβ 1 to 40 and 1 to 42 levels in hippocampal lysate were analyzed using the Aβ1 - 40 and Aβ1 - 42 ELISA kits from Invitrogen (# KHB3481 and # KHB3442, respectively).

Eid T, Hammer J, Runden - Pran E, Roberg B, Thomas MJ, Osen K, Davanger S, Laake P, Torgner IA, Lee TS, Kim JH, Spencer DD, Ottersen OP, de Lanerolle NC (2006) Increased expression of phosphate - activated glutaminase in hippocampal neurons in human mesial temporal lobe epilepsy.

The study was a continuation of a larger project by Jocelyne Bachevalier, PhD, at Yerkes National Primate Research Center, which studied how hippocampal damage within the first month of life affect cognitive development and memory.

A mouse that remembers the chamber context and associates it with the foot shock will spend more time freezing and this response is hippocampal dependent.

Abundant amyloid plaque deposition is evident throughout all cortical layers, hippocampal formation and amygdala in homozygote transgenic rats.

In the AD reversal treatment strategy described here, J147 significantly improved several different aspects of memory affected in AD, including spatial memory, a disinhibition phenotype and hippocampal dependent associative learning (Figure 1).

In rats, hippocampal theta is seen mainly in two conditions: first, when an animal is running, walking, or in some other way actively interacting with its surroundings; second, during REM sleep (Vanderwolf, 1969).

Egr proteins play a role in the regulation of synaptic plasticity, learning and memory [76, 77] and Egr3 in particular is very important for the processing of both short term and long term hippocampal dependent memory [78].

Estrogen enhances hippocampal gray - matter volume in young and older postmenopausal women: a prospective dose - response study.

Lindauer RJL, Vlieger EJ, Jalink M, Olff M, Carlier IVE, Majoie CBLM, den Heeten GJ, Gersons BPR, Effects of psychotherapy on hippocampal volume in out - patients with post-traumatic stress disorder: a MRI investigation.

Fear conditioning measures hippocampal - dependent associative learning.

The hippocampal theta rhythm depends critically on projections from the medial septal area, which in turn receives input from the hypothalamus and several brainstem areas.

Following three months of treatment, all mice were analyzed for spatial memory by the two - day water maze, disinhibition phenotype by the elevated plus maze and hippocampal dependent memory by fear conditioning.

Several types of hippocampal and entorhinal neurons are capable of generating theta - frequency membrane potential oscillations when stimulated.

One hypothesis is that diets that are high in saturated fat impair hippocampal function and that this leads to a deficit in memory performance [10].

Under certain conditions, theta - like oscillations can be induced in hippocampal or entorhinal cells in the absence of septal input, but this does not occur in intact, undrugged adult rats.

SR - / - mice had reduced dendritic spines and hippocampal volume.

Dendritic spines elongate after stimulation of group 1 metabotropic glutamate receptors in cultured hippocampal neurons.

c - Jun N - terminal kinase activation responses induced by hippocampal kindling are mediated by reactive astrocytes.

17 [beta]- estradiol induced Ca2 + influx via L - type calcium channels activates the Src / ERK / cyclic - AMP response element binding protein signal pathway and Bcl - 2 expression in rat hippocampal neurons: a potential initiation mechanism for estrogen - induced neuroprotection.

17 [beta]- estradiol induces Ca2 + influx, dendritic and nuclear Ca2 + rise and subsequent cyclic AMP response element - binding protein activation in hippocampal neurons: A potential initiation mechanism for estrogen neurotrophism.

Mapping Cofilin - Actin Rods in Stressed Hippocampal Slices and the Role of cdc42 in Amyloid - β - Induced Rods.

Non-Alcoholic Fatty Liver Disease Impairs Hippocampal - Dependent Memory in Male Rats.

Aadit has an interest in neuroscience and is working this summer to perfect our hippocampal primary cell model as well as chaperone Western blotting.

Nicotine Elicits Prolonged Calcium Signaling along Ventral Hippocampal Axons.

Membrane estrogen receptors mediate calcium signaling and MAP kinase activation in individual hippocampal neurons.

In a mirror study, chemotherapy administration in young and elderly mice resulted in a change in behavioral flexibility and alteration of neuron precursor proliferation in the hippocampal dentate gyrus.

«The dynamic is, the hippocampal engram is active [at first] and goes down, and the prefrontal - cortex engram is silent at the beginning and slowly becomes active,» Tonegawa said.

Furthermore, simultaneous electrophysiological recording and Ca2 + imaging in hippocampal neurons revealed that the sAHP reduction was associated with a decrease in parallel RyR - mediated Ca2 + transients.

These results demonstrate that NMDAR hypofunction can reproduce the numerous hippocampal deficits associated with schizophrenia, which can be reversed by chronic peripheral D - serine treatment.