Sentences with phrase «histone code»
The phrase "histone code" refers to certain changes or modifications happening on histone proteins in our genetic material. These changes play an essential role in controlling the activity of different genes, like an instruction manual, by determining whether a gene is turned on or off. It helps cells to function properly and regulate various processes in our bodies. Full definition
The role of histone codes and DNA methylation in silencing tumor suppressor genes, Cancer Cell 3:89 - 95, 2003.
hopkinsmedicine.org
One of the biggest controversies in the field is whether histone modifications are inherited through cell division (called the «histone code hypothesis») or whether they only form transient indicators of transcriptional states («signaling model»).
One form of epigenetic change physically blocks access to the genes by altering what is called the histone code.
«Epigenetic breakthrough: A first of its kind tool to study the histone code.»
University of North Carolina scientists have created a new research tool, based on the fruit fly, to help crack the histone code.
«This is exactly the type of combined effect predicted by the histone code hypothesis.»
The findings, also published in the journal Nature on April 10, provide evidence in support of the «histone code» hypothesis.
The histone code consists of the patterns formed by such marks, across the full genome.
«Unraveling mystery in «histone code» shows how gene activity is inherited.»
Today, researchers at Cold Spring Harbor Laboratory (CSHL) and colleagues publish research revealing a new layer of complexity in the histone code.
Now, Stanford University School of Medicine researchers have taken a new step in the deciphering of that histone code.
Furthermore, an examination of the histone code revealed that the regulatory genomic region of the transcription factors (ETS / GATA / SOX) was found to have gradually switched from a «brake histone mark,» which suppresses transcription, to an «accelerator histone mark,» which activates transcription, while in the process of differentiating into the vascular endothelium.
They found that the histone code, which alters the transcriptional state of the gene, changes over time as stem cells differentiate into blood vessels in response to a stimulus.
Another area of research in the lab concerns the mechanisms by which small double stranded RNAs can trigger transcriptional gene silencing and activation by modulating the histone code.
Multiple modifications (acetylation, methylation, ubquitination, phosphorylation) of multiple histones (5 major families) combined with a multitude of effects on chromatin give rise to a complex «histone code» that signals the transcriptional machinery to turn genes on or off.
In recent years, crosstalk has been observed between different histones, giving rise to further complexity in the histone code.
Several types of chemical modifications of the five major histone protein families give rise to a complex «histone code» that signals the transcriptional machinery to turn genes on or off.
«As a field, we have only started to appreciate the intricate complexity of this histone code.
Her graduate work culminated in multiple publications in the field of cancer epigenetics and in a thesis entitled «Aberrant epigenetic silencing of tumor suppressor genes in human cancer: the roles of DNA hypermethylation and the histone code.»