Together, Shapira suggests, these species represent a
basic hologenome, with essential, co-evolving symbionts, but also with a pool of microbes useful for flexibly adapting to a changing environment.
«
The hologenome is the biggest breakthrough in thinking I've had in my...
He came up with what he called
the hologenome theory of evolution.
If the results can be replicated in other species, it will represent a boost for
the hologenome theory of evolution — the idea that the object of natural selection is not the individual organism nor even just its genes, but also those of the microbes it hosts.
If further experiments show that
the hologenome theory applies to animals like mice, it would not invalidate the basic idea of natural selection giving rise to new species.
Host biology in light of the microbiome: Ten principles of holobionts and
hologenomes.
«You have to look at
the hologenome to understand an animal or plant.»
Wasps of different species can mate successfully if we tinker with their gut bugs, backing the «
hologenome» idea that bacteria shape their hosts» evolution
They are all part of a single «
hologenome.»
«When I came across the paper by Ilana Zilber - Rosenberg and Eugene Rosenberg describing
the hologenome concept, it blew my mind,» Shapira said.
In his recent paper, Shapira elaborates on a 2008 proposal by Tel Aviv University researchers that evolution can act on
the hologenome, rather than on the genomes of the host and its microbiota separately.
These examples, he says, bolster the relatively recent concept of
the hologenome, a term referring to the genomes of the host and its microbes together, encompassing perhaps thousands of different types of bacteria on the skin, in the gut and even in reproductive organs.
Microbiologists have coined new terms for these collective entities — holobiont — and for their genomes —
hologenome.
At the American Society of Microbiology General Meeting in June, he convened the inaugural session on «Holobionts and
Their Hologenomes» and ASM's flagship journal mBio plans to publish a special issue on the topic in the coming year.
The first principle they advance is that holobionts and
hologenomes are fundamental units of biological organization.
Another is that evolutionary forces such as natural selection and drift may act on
the hologenome not just on the genome.
In the article «Host Biology in Light of the Microbiome: Ten Principles of Holobionts and
Hologenomes» published online Aug. 18 in the open access journal PLOS Biology, Bordenstein and his colleague Kevin Theis from the University of Michigan take the general concepts involved in this new paradigm and break them down into underlying principles that apply to the entire field of biology.
Holobionts and
their hologenomes: Evolution with mixed modes of inheritance — Karen Luisa Haag — Genetics and Molecular Biology