Sentences with word «homodimer»

The pathogenetic background of this additional alteration is completely unknown, but it is speculated that the mutant - FLT3 receptor homodimers in patients with loss of wt - FLT3 have a stronger transforming capacity compared to mut / wt heterodimers.

Another unconventional T cell subset with some features of innate immune cells is the intestinal intraepithelial lymphocytes (IEL) that express CD8αα homodimers, but neither CD4 nor CD8αβ.

Point mutations of a putative phosphorylation site can specifically abrogate transcriptional activity of a specific homodimer assembly, with little effect on other configurations.

These ZFNs modify a native endogenous locus as efficiently as the parental architecture, but with a > 40-fold reduction in homodimer function and much lower levels of genome - wide cleavage.

The Rel - associated protein pp40 is functionally related to I kappa B, an inhibitor of the transcription factor NF - kappa B. Purified pp40 inhibits the DNA binding activity of the NF - kappa B protein complex (p50: p65 heterodimers), p50: c - Rel heteromers, and c - Rel homodimers.

Comparison of the BRCC36 homodimer (top) with the BRCC36 - KIAA0157DC heterodimer (bottom) reveals similarities in MPN domain association but disorder of the helical bundle region.

Using the current ZFN architecture, however, cleavage - competent homodimers may also form that can limit safety or efficacy via off - target cleavage.

Both structures are CXCR4 homodimers, with IT1t or CVX15 located in the ligand - binding cavity that comprises the N - terminal, ECL2, ECL3 and TM domains.

Sigma (St Louis, MO, USA): Anti-Amyloid Precursor Protein, C - terminal, polyclonal, 95 to 100 kDa; Anti-Nerve Growth Factor 2.5 S, polyclonal homodimer, 26 kDa.

Two independent reports have pointed the existence of a complex composed of STAT2 homodimers and IRF - 9 without STAT1 in IFNα - treated cells (32, 33), but this finding was tempered by the facts that their authors mentioned that this complex displayed only limited DNA - binding affinity for an ISRE sequence.

The transcription factors usually function as homodimers or heterodimers to regulate the gene expression in eukaryotic cells and their activities are dependent on distinct protein - protein interaction.

We have collaborated extensively with the Hilde Cheroutre laboratory at our Institute on several projects, including investigation of the function of intestinal intraepithelial lymphocytes (IEL), particularly those that exclusively express CD8αα homodimers.

This information can be used to predict the protein structure of the homodimer.

Homodimers are identical pairs of protein chains (proteins, green and blue) that bind to each other.

A BLAST search against the human genome was then used to determine the top 15 off - target binding sites by allowing up to six mismatches per ZFP binding site, a 5 or 6 bp gap between ZFPs, and formation of hetero or homodimers (Table S2)[23].

We have also studied the function of the TL antigen, a nonclassical MHC class I antigen molecule highly expressed in the intestine that interacts with CD8αα homodimers.