Sentences with word «homozygotes»

Abundant amyloid plaque deposition is evident throughout all cortical layers, hippocampal formation and amygdala in homozygote transgenic rats.

(In the unlikely case of a female homozygote for hemophilia, whose father would have to be a hemophiliac himself, she would in most cases die during development.

The inclusion of homozygotes (possessing two copies of the ridged alleles) would make the observed incidence be less than 25 % when averaged across the population in the study.

There thus appears to be a deleterious effect of the heterozygous genotype on CU traits: however, as true heterozygous effects are rare and the numbers of minor homozygotes in the high CU group are small, replication is required in larger cohorts to determine whether this is a true effect.

Turning to the E-risk cohort, we found that breastfed children carrying the C allele showed a 7.0 - IQ - point advantage relative to children not fed breast milk (t = 7.91, P < 0.001), whereas GG homozygotes neither gained an advantage from breastfeeding nor suffered a disadvantage from not being fed breast milk (t = 0.22, P = 0.83)(Fig. 1 B).

Conversely, transgenic homozygote rats exhibited significant fear conditioning deficits as evidenced by comparable freezing levels throughout all test phases (F2, 10 = 1.01; p > 0.05).

Upon tone presentation, homozygote rats presented significantly lower freezing responses compared to non-transgenic animals (F2, 19 = 3.37; p < 0.05).

We also demonstrate that cxcr4 can be safely and efficiently disrupted in CD4 + T cells obtained from ccr5Δ32 homozygotes resulting in cells resistant to all strains of HIV - 1 tested.

However, with increasing age and advancing amyloid pathology, fear conditioning deficits severely progressed in homozygote animals (Figure 6d - f).

Injection of recombinant leptin into obese homozygotes sharply reduces body weight, decreases food intake, increases energy expenditure, and restores fertility in male mice.

Because homozygote AIP knockout mice are not viable (17, 18) and there is no doubt regarding the pathogenic potential of the truncating R304 * mutation, the A299V variant is most likely to be a clinically insignificant change.

This gene is allelic with the gene AlA which controls the common albumin.Both homozygotes and heterozygotes have been distinguished.

Such a monitoring program, the researchers write, would «sound a warning bell before resistant homozygotes become frequent enough to cause uncontrollable outbreaks.»

«People assumed that every black had it, as if homozygotes were out there in numbers.

The dwarf phenotype ofchico homozygotes was also unnecessary for extension of life - span.

This lets us ask, for example, whether homozygosity for certain very rare coding mutations would be lethal to humans because such homozygotes can (theoretically) be found in isolates.

Conversely, freezing behavior was significantly lower in McGill homozygote transgenic rats (F2, 19 = 9.528; p < 0.01).

Myofibers in Dysfprmd homozygotes undergo degeneration and regeneration, and their nuclei are placed centrally.

The two lines: one is homozygote form of these mice of genotype, the homozygous genotype; and one is a heterozygous genotype.

To obtain fat bodies, we also used carefully staged 24 h AL3E w1118, gbp1, gbp2 ex67 heterozygote, and gbp1, gbp2 ex67 homozygote larvae.

However, response to treatment may be predicted by baseline frontal lobe blood flow, and presence of polymorphisms of the 5 - hydroxytryptamine (5 - HT)-1 a gene, the LL genotype of the serotonin transporter linked polymorphic region (5 - HTTLPR) gene, and Val / Val homozygotes of the brain - derived neurotrophic factor (BDNF) gene.

However, Pde6brd1, the recessive retinal degeneration 1 mutation, is segregating in this stock; Pde6brd1 homozygotes are blind.

Although hyperphagia contributes to the obesity, homozygotes gain excess weight and deposit excess fat even when restricted to a diet sufficient for normal weight maintenance in lean mice.

So far we have tested 1690 dogs, 53 % were negative, 41 % were positive heterozygotes and 6 % were positive homozygotes.

A study based on 392 Australian Shepherds indicates that about 50 % of dogs carrying one copy of the deletion develop bilateral posterior cataracts when they are about 5 years old, while homozygotes (i.e. dogs carrying two copies of the HSF4 - 2 mutation) are more likely to develop a nuclear form of cataract that typically progresses to complete cataract (2).

The direction of this results is concordant with previous research that demonstrated that adolescents homozygous for the major (C) allele of rs6314 had significantly higher levels of antisocial behaviour and rule breaking, although notably not aggression, than heterozygotes and minor homozygotes [61].

A1 carriers were more susceptible to negative parenting compared to A2A2 homozygotes, such that adolescents carrying A1 alleles experiencing high negative parenting reported more depressive symptoms but fared better when experiencing low negative parenting.

ADHD Symptoms in Middle Adolescence Predict Exposure to Person - Related Life Stressors in Late Adolescence in 5 - HTTLPR S - allele Homozygotes.

+ / + - Homozygotes for this variant allele in the CTH gene had significantly higher plasma homocysteine levels than other genotypes in a cohort of 496 Caucasian individuals.

Breastfed A-carriers had higher IQs than nonbreastfed A-carriers, whereas this advantage was not as pronounced among GG homozygotes (breastfed children with AA, AG, and GG genotypes had IQs of 104.6, 104.6, and 100.0, whereas nonbreasfted children had IQs of 97.7, 96.8, and 98.6).

Human CD4 + T cells from a ccr5Δ32 homozygote were transduced with AdX4 - ZFNs or AdR5 - ZFNs and subsequently infected with HIV - 1 strains Bk132, HxB2, and R3A as described above.

In 13 - month old transgenic rats with advanced amyloid pathology we revealed marked contextual fear conditioning deficits in homozygote animals.

On the C57BLKS background, obese homozygotes (Stock No. 000696) become severely diabetic with regression of islets and early death.

Participants homozygous for the major allele (CC) were more likely to have high CU traits than heterozygotes (C / T) or minor homozygotes (TT).

At this early time - point, transgenic homozygotes and heterozygote rats had comparable fear conditioning responses throughout all test phases.

AFFECTED - homozygotes with two copies of the mutated PLA2G6 gene develop clinical signs of NAD and they can only pass the mutated gene on to their offspring, although they usually die you and do not reproduce.