The Dengue virus contains discretely folded RNA structures that confer the ability to resist a powerful
host cell enzyme and produce a disease - inducing noncoding RNA.
Not exact matches
In a
host cell, the viruses have the
enzymes needed to wrangle all 20 standard amino acids, the building blocks of life.
The viruses also exploit an
enzyme that
cells use to destroy RNA to instead produce short stretches of RNA that, among other things, may help the virus avoid the immune system of its
host.
The new study shows that the synthetic compound is capable of inhibiting the activities of several DNA - processing
enzymes, including the «integrase» used by the Human Immunodeficiency Virus (HIV) to insert its genome into that of its
host cell.
The microbe swims freely through the blood and feeds off its
host, behaving like the single -
celled animal it is, but it produces
enzymes and lipids thought to be exclusive to plants.
Thus, the two small phages characterized for their lysis strategy, Qβ and the small DNA phage φX174, effect
host lysis by targeting different
enzymes in the multistep, universally conserved pathway of
cell wall biosynthesis.
«Importantly, fighting a pathogen by hitting an
enzyme from the
host cell is likely to slow the emergence of drug resistance, because the pathogen can not easily escape through the selection of target mutations,» Professor Doerig said.
Massive lateral transfer of genes encoding plant
cell wall - degrading
enzymes to the mycoparasitic fungus Trichoderma from its plant - associated
hosts
Animal experiments Cytosolic and secreted peptidoglycan - degrading
enzymes in Drosophila respectively control local and systemic immune responses to microbiota — Bernard Charroux —
Cell Host & Microbe
By teasing apart the structure of an
enzyme vital to the parasites that cause toxoplasmosis and malaria, Whitehead Institute scientists have identified a potentially «drugable» target that could prevent parasites from entering and exiting
host cells.
«Our study focused on a class of
enzymes called methyltransferases, which have emerged as key regulators of HIV latency,» explained Melanie Ott, MD, PhD, a senior investigator at Gladstone and lead author of the study published in the scientific journal
Cell Host & Microbe.
When our digestive systems are sick or damaged, the
host of
cells, bacteria, and
enzymes that break down food and absorb nutrients, are unable to perform their important functions.
This
enzyme allows the flu virus to bud from the
host cell in which it was created and then happily pass through the mucus of the respiratory tract to any
cell in the tract it wishes to infect.
In order to colonize the urogenital tract, T. vaginalis must be able to adhere to the
host's
cells, which it is able to do by producing
enzymes that degrade the surfaces of the
host's
cells.