Sentences with phrase «host cell interactions»

Molecular and cell biology of retrovirus - host cell interactions — Development and application of retroviral gene transfer and drug screening systems

The Polonis lab has also employed both cell line - based model systems, as well as primary cell types from uninfected humans, to investigate virus - antibody - host cell interactions and cross-subtype reactivities amongst the major subtypes of the HIV pandemic.

After serving as a Peace Corps volunteer in the Democratic Republic of Congo, she entered the MD - PhD program at Yale University where she studied influenza virus - host cell interactions in the laboratory of Dr. Ari Helenius, receiving her PhD degree in Molecular Biophysics and Biochemistry and her MD degree in 1992.

- Our results show that these antiviral drugs and their combinations are potent inhibitors of Zika virus - host cell interaction.

In another study published this week the group investigated influenza pH1N1 virus - host cell interaction in detail and found that certain host function could be temporally inhibited with small molecule MK2206 to block influenza infection in cell culture.

In January 2015, I began working as a postdoctoral fellow at LIAI studying virus - host cells interactions in animal models and human cells.

Not exact matches

Dr Stotz continued: «This concept of plant ETI does not really explain the second line of defense in the interaction of plant hosts protecting themselves against extracellular fungal pathogens — i.e. those foliar fungal pathogens that get into the leaf of the plant to exploit the space between its cells, known as the apoplast, to retrieve nutrients from the plant.

«Cardiac stem cells from heart disease patients may be harmful: Researchers discover molecular pathway involved in toxic interaction between host cells and immune system.»

Identifying a role for tuft cells in the interactions between the virus and its host «is a significant step forward,» says immunologist David Artis of Weill Cornell Medicine in New York City, who was not involved in the study.

It indicates that the interaction with mitochondria is driven by Toxoplasma, rather than the host cell, and it is likely something the parasite does «to enable survival in some particular subset of hosts,» he says.

«The new model enables studies of the complex interactions between host cells, mucus production, and gut microbes in a system that closely mimics the situation in human patients,» Dawson said.

The results, revealing new examples of heritable bacterial species — including those related to diet preference, metabolism, and immune defense — appear May 11 in Cell Host & Microbe's special issue on the «Genetics and Epigenetics of Host - Microbe Interactions.»

One of the main ways that hosts manage their interactions with microbes is by carefully controlling the genes that their cells use.

«When we study the interactions between the host cell and the virus, we get information about both of them and about how cellular machinery is working under viral infection,» says Alessia Ruggieri, a group leader and virologist at University of Heidelberg in Germany and senior researcher on the study.

Cellular Decision Making and Interactions, including stem cell biology, host - microbiome interactions, differentiation and disease, evolution, andInteractions, including stem cell biology, host - microbiome interactions, differentiation and disease, evolution, andinteractions, differentiation and disease, evolution, and immunology.

Their findings — that nanotubes and vesicles are an important part of the communications process — show that the extracellular vesicles contribute to the complexity of African trypanosomiasis through the transfer of virulence factors between parasites and inadvertent interaction with host cells, which has a profound effect on disease, the study notes.

Instead of using light energy to produce food to support the salamander host, as happens in coral - algae interactions, the algae in salamander cells struggle to adapt to their new environment.

These cells allow for large scale screening using RNAi and have been successfully used to identify proteins involved in host interactions with important human bacterial pathogens such as Escherichia coli, Staphylococcus aureus [42], [43], Mycobacterium spp. [44], Legionella pneumophila [45], Chlamydia spp. [46]--[48] and Listeria monocytogenes [49]--[51].

Published in the January 22 issue of Molecular Cell, the investigators created full protein interaction maps — interactomes — of where the viruses come into contact with the host proteins during the course of infection.

With respect to technology development, the group is leveraging recent advances in nanotechnology and chemical biology to establish a host of core, cross-disciplinary platforms that will collectively enable them to extensively profile and precisely control cells and their interactions within the context of complex systems.

With respect to biological applications, the group is focusing on how cellular heterogeneity and cell - to - cell communication drive ensemble - level decision - making in the immune system, with an emphasis on «two - body» interaction (e.g., host cell - virus interactions, innate immune control of adaptive immunity, tumor infiltration by immune cells).

This resulted in over 5,000 virus - host protein - to - protein interactions, which the investigators narrowed down to 139 key connections that are necessary for HCV infection, involving all 10 HCV proteins and 133 proteins in the host liver cells.

This resulted in a staggering 50,000 virus - host protein interactions, approximately 500 of which appeared to be involved in viral infection.By removing the interacting host proteins from the cell one at a time, the researchers were able to determine what their functional contribution was in the infection process: whether the host proteins were hijacked by the virus and used to spread infection, or whether they were part of a defense mechanism against the virus.

These interactions trigger a conformational change in gp41, causing a pH - dependent fusion of the viral and the host cell membranes and thus the delivery of the viral payload.

Proteins on the surface of both the Plasmodium sporozoite and human host cells are likely to be important in this journey, but little is known about the exact interactions which occur.

Areas of particular interest are host - pathogen interactions, pattern recognition receptors, cellular signaling and immunometabolism, and myeloid cell development.

These interactions lead to a conformational change in the viral TM protein gp41, causing a pH - dependent fusion of the viral and the host cell membranes and the delivery of the viral payload [15 - 18].

A virus or more in (nearly) every cell: ubiquitous networks of virus - host interactions in extreme environments.

His success in studying virus - host interactions inspired him to tackle an even more difficult question: How do tumor cells turn against their hosts and eventually kill the cancer patients.

The focus is on molecular microbiology and virology, and includes topics such as genomics, the gamut of plant and animal host - pathogen interactions, host immune responses, characterization and evolution of virulence determinants, cell cycle and differentiation, symbiosis in plant and animal associations, environmental microbiology, biodiversity and evolution, population dynamics, sex and mutagenesis, antibiotic resistance and production, drug and vaccine targets, as well as aspects of prion diseases and of fungal and protozoan biology.

Her studies there focused on investigating host - pathogen interactions between Mycobacterium tuberculosisand pulmonary immune cells during the early stages of infection.

Dr. Al - Homsi's research holds tremendous promise to curtail negative interactions between host and transplanted cells and make this form of treatment safer and more effective.»

Dr. Zutter focuses on the role of cell adhesion molecules in host - tumor interactions.

I completed my Ph.D. in Microbiology in November 2016 from the University of Kansas after researching host cell - viral interactions of HSV - 1 in cell culture models.

Inter-species interactions in the freshwater polyp Hydra between symbiotic algae and host cells had been the subject of research since decades since they not only...

Cell wall components and secreted proteins show the greatest variation, indicating their potential role in host - bacillus interactions or immune evasion.

Though isolates were identical by laboratory typing methods, we uncovered many differences in their genomes, in gene expression, and in their interactions with host cells.

There is no evidence in Marek's disease that vaccine breakthrough by more virulent strains has anything to do with overcoming strain - specific immunity (e.g., epitope evolution); genetic and immunological comparisons of strains varying in virulence suggest that candidate virulence determinants are associated with host — cell interactions and viral replication, not antigens [19].